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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Plasma proteins RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
q23.1
Chromosome location (bp)
107249482 - 107498055
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Angiogenesis, Differentiation
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Mutations in this gene are associated with hereditary angioedema. [provided by RefSeq, Aug 2020]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Cardiovascular diseases Vascular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001525[angiogenesis] GO:0001934[positive regulation of protein phosphorylation] GO:0002040[sprouting angiogenesis] GO:0002092[positive regulation of receptor internalization] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005886[plasma membrane] GO:0005902[microvillus] GO:0007162[negative regulation of cell adhesion] GO:0007171[activation of transmembrane receptor protein tyrosine kinase activity] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0014842[regulation of skeletal muscle satellite cell proliferation] GO:0030154[cell differentiation] GO:0030210[heparin biosynthetic process] GO:0030971[receptor tyrosine kinase binding] GO:0031398[positive regulation of protein ubiquitination] GO:0034394[protein localization to cell surface] GO:0042802[identical protein binding] GO:0043066[negative regulation of apoptotic process] GO:0043116[negative regulation of vascular permeability] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045121[membrane raft] GO:0048014[Tie signaling pathway] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050918[positive chemotaxis] GO:0051897[positive regulation of protein kinase B signaling] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0072012[glomerulus vasculature development] GO:1905605[positive regulation of blood-brain barrier permeability] GO:2000352[negative regulation of endothelial cell apoptotic process]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Cardiovascular diseases Vascular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0001701[in utero embryonic development] GO:0001933[negative regulation of protein phosphorylation] GO:0001934[positive regulation of protein phosphorylation] GO:0002040[sprouting angiogenesis] GO:0002092[positive regulation of receptor internalization] GO:0002719[negative regulation of cytokine production involved in immune response] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005886[plasma membrane] GO:0005902[microvillus] GO:0007162[negative regulation of cell adhesion] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007171[activation of transmembrane receptor protein tyrosine kinase activity] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014842[regulation of skeletal muscle satellite cell proliferation] GO:0030097[hemopoiesis] GO:0030154[cell differentiation] GO:0030210[heparin biosynthetic process] GO:0030971[receptor tyrosine kinase binding] GO:0031398[positive regulation of protein ubiquitination] GO:0031589[cell-substrate adhesion] GO:0032680[regulation of tumor necrosis factor production] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0034394[protein localization to cell surface] GO:0042308[negative regulation of protein import into nucleus] GO:0042802[identical protein binding] GO:0043066[negative regulation of apoptotic process] GO:0043116[negative regulation of vascular permeability] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043393[regulation of protein binding] GO:0043524[negative regulation of neuron apoptotic process] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045121[membrane raft] GO:0045785[positive regulation of cell adhesion] GO:0048014[Tie signaling pathway] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050918[positive chemotaxis] GO:0051402[neuron apoptotic process] GO:0051897[positive regulation of protein kinase B signaling] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0072012[glomerulus vasculature development] GO:1905605[positive regulation of blood-brain barrier permeability] GO:2000352[negative regulation of endothelial cell apoptotic process] GO:2000446[regulation of macrophage migration inhibitory factor signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Cardiovascular diseases Vascular diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Cardiovascular diseases Vascular diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Cardiovascular diseases Vascular diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
