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PGM5
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  • PGM5
PROTEIN SUMMARY GENE INFORMATION RNA DATA ANTIBODY DATA
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

PGM5
Synonyms PGMRP
Gene descriptioni

Full gene name according to HGNC.

Phosphoglucomutase 5
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 9
Cytoband q21.11
Chromosome location (bp) 68328308 - 68531061
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

3
Ensembl ENSG00000154330 (version 109)
Entrez gene 5239
HGNC HGNC:8908
UniProt Q15124 (UniProt - Evidence at protein level)
neXtProt NX_Q15124
GeneCards PGM5
Antibodypedia PGM5 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i

Useful information about the protein provided by UniProt.

Component of adherens-type cell-cell and cell-matrix junctions 1. Has no phosphoglucomutase activity in vitro 2.... show less
Biological process (UniProt)i

Keywords assigned by UniProt to proteins because they are involved in a particular biological process.

Cell adhesion
Gene summary (Entrez)i

Useful information about the gene from Entrez

Phosphoglucomutases (EC 5.2.2.2.), such as PGM5, are phosphotransferases involved in interconversion of glucose-1-phosphate and glucose-6-phosphate. PGM activity is essential in formation of carbohydrates from glucose-6-phosphate and in formation of glucose-6-phosphate from galactose and glycogen (Edwards et al., 1995).[supplied by OMIM, Mar 2008]... show less
PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
PGM5-201
ENSP00000379674
ENST00000396392
Q15124
[Direct mapping] Phosphoglucomutase-like protein 5
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001725 [stress fiber]
GO:0004614 [phosphoglucomutase activity]
GO:0005198 [structural molecule activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005914 [spot adherens junction]
GO:0005925 [focal adhesion]
GO:0005975 [carbohydrate metabolic process]
GO:0007155 [cell adhesion]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0014704 [intercalated disc]
GO:0014706 [striated muscle tissue development]
GO:0016010 [dystrophin-associated glycoprotein complex]
GO:0016020 [membrane]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0030055 [cell-substrate junction]
GO:0030239 [myofibril assembly]
GO:0042383 [sarcolemma]
GO:0043034 [costamere]
GO:0070161 [anchoring junction]
GO:0071704 [organic substance metabolic process]
Show all
387 aa
41.8 kDa
No 0
PGM5-202
ENSP00000379678
ENST00000396396
Q15124
[Direct mapping] Phosphoglucomutase-like protein 5
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001725 [stress fiber]
GO:0004614 [phosphoglucomutase activity]
GO:0005198 [structural molecule activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005914 [spot adherens junction]
GO:0005925 [focal adhesion]
GO:0005975 [carbohydrate metabolic process]
GO:0007155 [cell adhesion]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0014704 [intercalated disc]
GO:0014706 [striated muscle tissue development]
GO:0016010 [dystrophin-associated glycoprotein complex]
GO:0016020 [membrane]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0030018 [Z disc]
GO:0030055 [cell-substrate junction]
GO:0030239 [myofibril assembly]
GO:0042383 [sarcolemma]
GO:0043034 [costamere]
GO:0070161 [anchoring junction]
GO:0071704 [organic substance metabolic process]
Show all
567 aa
62.2 kDa
No 0
PGM5-203
ENSP00000394864
ENST00000431583
Q5JTY7
[Direct mapping] Phosphoglucomutase-like protein 5
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004614 [phosphoglucomutase activity]
GO:0005975 [carbohydrate metabolic process]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
Show all
205 aa
21.8 kDa
No 0

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