We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q14.2
Chromosome location (bp)
119366924 - 119372550
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transport
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Lipid-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062[fatty-acyl-CoA binding] GO:0005515[protein binding] GO:0005783[endoplasmic reticulum] GO:0005788[endoplasmic reticulum lumen] GO:0005794[Golgi apparatus] GO:0006631[fatty acid metabolic process] GO:0008289[lipid binding] GO:0030156[benzodiazepine receptor binding] GO:0032994[protein-lipid complex] GO:0036042[long-chain fatty acyl-CoA binding] GO:0036151[phosphatidylcholine acyl-chain remodeling] GO:0042802[identical protein binding] GO:0070062[extracellular exosome] GO:1903060[negative regulation of protein lipidation] GO:1905920[positive regulation of CoA-transferase activity] GO:2001140[positive regulation of phospholipid transport]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062[fatty-acyl-CoA binding] GO:0005783[endoplasmic reticulum] GO:0005788[endoplasmic reticulum lumen] GO:0005794[Golgi apparatus] GO:0006631[fatty acid metabolic process] GO:0008289[lipid binding] GO:0030156[benzodiazepine receptor binding] GO:0032994[protein-lipid complex] GO:0036042[long-chain fatty acyl-CoA binding] GO:0036151[phosphatidylcholine acyl-chain remodeling] GO:0042802[identical protein binding] GO:0070062[extracellular exosome] GO:1903060[negative regulation of protein lipidation] GO:1905920[positive regulation of CoA-transferase activity] GO:2001140[positive regulation of phospholipid transport]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062[fatty-acyl-CoA binding] GO:0005783[endoplasmic reticulum] GO:0005788[endoplasmic reticulum lumen] GO:0005794[Golgi apparatus] GO:0006631[fatty acid metabolic process] GO:0008289[lipid binding] GO:0030156[benzodiazepine receptor binding] GO:0032994[protein-lipid complex] GO:0036042[long-chain fatty acyl-CoA binding] GO:0036151[phosphatidylcholine acyl-chain remodeling] GO:0042802[identical protein binding] GO:0070062[extracellular exosome] GO:1903060[negative regulation of protein lipidation] GO:1905920[positive regulation of CoA-transferase activity] GO:2001140[positive regulation of phospholipid transport]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062[fatty-acyl-CoA binding] GO:0005515[protein binding] GO:0005783[endoplasmic reticulum] GO:0005788[endoplasmic reticulum lumen] GO:0005794[Golgi apparatus] GO:0006631[fatty acid metabolic process] GO:0008289[lipid binding] GO:0030156[benzodiazepine receptor binding] GO:0032994[protein-lipid complex] GO:0036042[long-chain fatty acyl-CoA binding] GO:0036151[phosphatidylcholine acyl-chain remodeling] GO:0042802[identical protein binding] GO:0070062[extracellular exosome] GO:1903060[negative regulation of protein lipidation] GO:1905920[positive regulation of CoA-transferase activity] GO:2001140[positive regulation of phospholipid transport]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062[fatty-acyl-CoA binding] GO:0005515[protein binding] GO:0005783[endoplasmic reticulum] GO:0005788[endoplasmic reticulum lumen] GO:0005794[Golgi apparatus] GO:0006631[fatty acid metabolic process] GO:0008289[lipid binding] GO:0030156[benzodiazepine receptor binding] GO:0032994[protein-lipid complex] GO:0036042[long-chain fatty acyl-CoA binding] GO:0036151[phosphatidylcholine acyl-chain remodeling] GO:0042802[identical protein binding] GO:0070062[extracellular exosome] GO:1903060[negative regulation of protein lipidation] GO:1905920[positive regulation of CoA-transferase activity] GO:2001140[positive regulation of phospholipid transport]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062[fatty-acyl-CoA binding] GO:0005783[endoplasmic reticulum] GO:0005788[endoplasmic reticulum lumen] GO:0005794[Golgi apparatus] GO:0006631[fatty acid metabolic process] GO:0008289[lipid binding] GO:0030156[benzodiazepine receptor binding] GO:0032994[protein-lipid complex] GO:0036042[long-chain fatty acyl-CoA binding] GO:0036151[phosphatidylcholine acyl-chain remodeling] GO:0042802[identical protein binding] GO:0070062[extracellular exosome] GO:1903060[negative regulation of protein lipidation] GO:1905920[positive regulation of CoA-transferase activity] GO:2001140[positive regulation of phospholipid transport]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062[fatty-acyl-CoA binding] GO:0005783[endoplasmic reticulum] GO:0005788[endoplasmic reticulum lumen] GO:0005794[Golgi apparatus] GO:0006631[fatty acid metabolic process] GO:0008289[lipid binding] GO:0030156[benzodiazepine receptor binding] GO:0032994[protein-lipid complex] GO:0036042[long-chain fatty acyl-CoA binding] GO:0036151[phosphatidylcholine acyl-chain remodeling] GO:0042802[identical protein binding] GO:0070062[extracellular exosome] GO:1903060[negative regulation of protein lipidation] GO:1905920[positive regulation of CoA-transferase activity] GO:2001140[positive regulation of phospholipid transport]
The Human Protein Atlas project is funded
