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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Potassium calcium-activated channel subfamily M alpha 1
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes FDA approved drug targets Human disease related genes Transporters Voltage-gated ion channels
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q22.3
Chromosome location (bp)
76869601 - 77638369
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+)1,2,3. It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Ion channel, Potassium channel, Voltage-gated channel
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Ion transport, Potassium transport, Transport
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Magnesium, Metal-binding, Potassium
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes the alpha subunit of calcium-activated BK channel. The encoded protein is involved in several physiological processes including smooth muscle contraction, neurotransmitter release and neuronal excitability. Mutations in this gene are associated with a spectrum of neurological disorders including Paroxysmal Nonkinesigenic Dyskinesia 3, Idiopathic Generalized Epilepsy 16 and Liang-Wang syndrome. [provided by RefSeq, Aug 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Transporters Transporter channels and pores Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0001666[response to hypoxia] GO:0003779[actin binding] GO:0005216[ion channel activity] GO:0005244[voltage-gated ion channel activity] GO:0005249[voltage-gated potassium channel activity] GO:0005267[potassium channel activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0005901[caveola] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006970[response to osmotic stress] GO:0008076[voltage-gated potassium channel complex] GO:0015269[calcium-activated potassium channel activity] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0022839[ion gated channel activity] GO:0030007[cellular potassium ion homeostasis] GO:0034465[response to carbon monoxide] GO:0034765[regulation of ion transmembrane transport] GO:0042391[regulation of membrane potential] GO:0042802[identical protein binding] GO:0043065[positive regulation of apoptotic process] GO:0045211[postsynaptic membrane] GO:0045794[negative regulation of cell volume] GO:0046872[metal ion binding] GO:0051592[response to calcium ion] GO:0055085[transmembrane transport] GO:0060072[large conductance calcium-activated potassium channel activity] GO:0060073[micturition] GO:0060083[smooth muscle contraction involved in micturition] GO:0060087[relaxation of vascular associated smooth muscle] GO:0071805[potassium ion transmembrane transport]
Transporters Transporter channels and pores Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0001666[response to hypoxia] GO:0003779[actin binding] GO:0005216[ion channel activity] GO:0005244[voltage-gated ion channel activity] GO:0005249[voltage-gated potassium channel activity] GO:0005267[potassium channel activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0005901[caveola] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006970[response to osmotic stress] GO:0008076[voltage-gated potassium channel complex] GO:0015269[calcium-activated potassium channel activity] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0022839[ion gated channel activity] GO:0030007[cellular potassium ion homeostasis] GO:0034465[response to carbon monoxide] GO:0034765[regulation of ion transmembrane transport] GO:0042391[regulation of membrane potential] GO:0043065[positive regulation of apoptotic process] GO:0045211[postsynaptic membrane] GO:0045794[negative regulation of cell volume] GO:0046872[metal ion binding] GO:0051592[response to calcium ion] GO:0055085[transmembrane transport] GO:0060072[large conductance calcium-activated potassium channel activity] GO:0060073[micturition] GO:0060083[smooth muscle contraction involved in micturition] GO:0060087[relaxation of vascular associated smooth muscle] GO:0071805[potassium ion transmembrane transport]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
Transporters Transporter channels and pores Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0001666[response to hypoxia] GO:0003779[actin binding] GO:0005216[ion channel activity] GO:0005244[voltage-gated ion channel activity] GO:0005249[voltage-gated potassium channel activity] GO:0005267[potassium channel activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0005901[caveola] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006970[response to osmotic stress] GO:0008076[voltage-gated potassium channel complex] GO:0015269[calcium-activated potassium channel activity] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0022839[ion gated channel activity] GO:0030007[cellular potassium ion homeostasis] GO:0034465[response to carbon monoxide] GO:0034765[regulation of ion transmembrane transport] GO:0042391[regulation of membrane potential] GO:0043065[positive regulation of apoptotic process] GO:0045211[postsynaptic membrane] GO:0045794[negative regulation of cell volume] GO:0046872[metal ion binding] GO:0051592[response to calcium ion] GO:0055085[transmembrane transport] GO:0060072[large conductance calcium-activated potassium channel activity] GO:0060073[micturition] GO:0060083[smooth muscle contraction involved in micturition] GO:0060087[relaxation of vascular associated smooth muscle] GO:0071805[potassium ion transmembrane transport]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
