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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
p21.3
Chromosome location (bp)
22604757 - 22620964
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions 1. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis 2,3,4. Inhibits SUV39H1 methyltransferase activity 5. Mediates ligand-dependent transcriptional activation by nuclear hormone receptors 6. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress 7. Regulates the circadian expression of the core clock components NR1D1 and BMAL1 8. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation 9. Represses the ligand-dependent transcriptional activation function of ESR2 10. Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 11. Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization 12. Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway 13. Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 14. Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 15. Represses the transcriptional activator activity of BRCA1 16. Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro 17....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, Metalloenzyme inhibitor, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Enables RNA polymerase II complex binding activity and enzyme inhibitor activity. Involved in several processes, including regulation of cellular protein metabolic process; regulation of signal transduction; and regulation of transcription, DNA-templated. Located in several cellular components, including mitochondrial matrix; nucleoplasm; and spindle. Part of DBIRD complex. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q8N163 [Direct mapping] Cell cycle and apoptosis regulator protein 2
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000993[RNA polymerase II complex binding] GO:0003723[RNA binding] GO:0004857[enzyme inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005759[mitochondrial matrix] GO:0005819[spindle] GO:0005856[cytoskeleton] GO:0006355[regulation of DNA-templated transcription] GO:0006397[mRNA processing] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0008380[RNA splicing] GO:0009411[response to UV] GO:0016055[Wnt signaling pathway] GO:0019899[enzyme binding] GO:0030308[negative regulation of cell growth] GO:0030374[nuclear receptor coactivator activity] GO:0031647[regulation of protein stability] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032784[regulation of DNA-templated transcription elongation] GO:0042752[regulation of circadian rhythm] GO:0043065[positive regulation of apoptotic process] GO:0043086[negative regulation of catalytic activity] GO:0043653[mitochondrial fragmentation involved in apoptotic process] GO:0044609[DBIRD complex] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0048511[rhythmic process] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0090311[regulation of protein deacetylation] GO:1902230[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:2000003[positive regulation of DNA damage checkpoint]
Q8N163 [Direct mapping] Cell cycle and apoptosis regulator protein 2
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000993[RNA polymerase II complex binding] GO:0003723[RNA binding] GO:0004857[enzyme inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005759[mitochondrial matrix] GO:0005819[spindle] GO:0005856[cytoskeleton] GO:0006355[regulation of DNA-templated transcription] GO:0006397[mRNA processing] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0008380[RNA splicing] GO:0009411[response to UV] GO:0016055[Wnt signaling pathway] GO:0019899[enzyme binding] GO:0030308[negative regulation of cell growth] GO:0030374[nuclear receptor coactivator activity] GO:0031647[regulation of protein stability] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032784[regulation of DNA-templated transcription elongation] GO:0042752[regulation of circadian rhythm] GO:0043065[positive regulation of apoptotic process] GO:0043086[negative regulation of catalytic activity] GO:0043653[mitochondrial fragmentation involved in apoptotic process] GO:0044609[DBIRD complex] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0048511[rhythmic process] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0090311[regulation of protein deacetylation] GO:1902230[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:2000003[positive regulation of DNA damage checkpoint]
H0YB24 [Direct mapping] Cell cycle and apoptosis regulator protein 2
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
G3V119 [Direct mapping] Cell cycle and apoptosis regulator protein 2; KIAA1967, isoform CRA_b
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
H0YC58 [Direct mapping] Cell cycle and apoptosis regulator protein 2
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SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
