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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
X
Cytoband
q28
Chromosome location (bp)
154517825 - 154547572
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Oxidoreductase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Carbohydrate metabolism, Glucose metabolism
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
NADP
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Human disease related genes Cardiovascular diseases Hematologic diseases Congenital disorders of metabolism Congenital disorders of amino acid metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0004345[glucose-6-phosphate dehydrogenase activity] GO:0005515[protein binding] GO:0005536[glucose binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005975[carbohydrate metabolic process] GO:0006006[glucose metabolic process] GO:0006098[pentose-phosphate shunt] GO:0006629[lipid metabolic process] GO:0006695[cholesterol biosynthetic process] GO:0006739[NADP metabolic process] GO:0006740[NADPH regeneration] GO:0006749[glutathione metabolic process] GO:0009051[pentose-phosphate shunt, oxidative branch] GO:0009898[cytoplasmic side of plasma membrane] GO:0010734[negative regulation of protein glutathionylation] GO:0016020[membrane] GO:0016491[oxidoreductase activity] GO:0016614[oxidoreductase activity, acting on CH-OH group of donors] GO:0019322[pentose biosynthetic process] GO:0021762[substantia nigra development] GO:0034451[centriolar satellite] GO:0034599[cellular response to oxidative stress] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043231[intracellular membrane-bounded organelle] GO:0043249[erythrocyte maturation] GO:0046390[ribose phosphate biosynthetic process] GO:0050661[NADP binding] GO:0051156[glucose 6-phosphate metabolic process] GO:0070062[extracellular exosome]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Human disease related genes Cardiovascular diseases Hematologic diseases Congenital disorders of metabolism Congenital disorders of amino acid metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0004345[glucose-6-phosphate dehydrogenase activity] GO:0005515[protein binding] GO:0005536[glucose binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005975[carbohydrate metabolic process] GO:0006006[glucose metabolic process] GO:0006098[pentose-phosphate shunt] GO:0006629[lipid metabolic process] GO:0006695[cholesterol biosynthetic process] GO:0006739[NADP metabolic process] GO:0006740[NADPH regeneration] GO:0006749[glutathione metabolic process] GO:0009051[pentose-phosphate shunt, oxidative branch] GO:0009898[cytoplasmic side of plasma membrane] GO:0010041[response to iron(III) ion] GO:0010734[negative regulation of protein glutathionylation] GO:0014070[response to organic cyclic compound] GO:0016020[membrane] GO:0016491[oxidoreductase activity] GO:0016614[oxidoreductase activity, acting on CH-OH group of donors] GO:0019322[pentose biosynthetic process] GO:0021762[substantia nigra development] GO:0030246[carbohydrate binding] GO:0032094[response to food] GO:0034451[centriolar satellite] GO:0034599[cellular response to oxidative stress] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043231[intracellular membrane-bounded organelle] GO:0043249[erythrocyte maturation] GO:0043523[regulation of neuron apoptotic process] GO:0045471[response to ethanol] GO:0046390[ribose phosphate biosynthetic process] GO:0050661[NADP binding] GO:0051156[glucose 6-phosphate metabolic process] GO:0061052[negative regulation of cell growth involved in cardiac muscle cell development] GO:0070062[extracellular exosome] GO:1904879[positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel] GO:2000378[negative regulation of reactive oxygen species metabolic process]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Human disease related genes Cardiovascular diseases Hematologic diseases Congenital disorders of metabolism Congenital disorders of amino acid metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004345[glucose-6-phosphate dehydrogenase activity] GO:0005515[protein binding] GO:0005536[glucose binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005975[carbohydrate metabolic process] GO:0006006[glucose metabolic process] GO:0006098[pentose-phosphate shunt] GO:0006629[lipid metabolic process] GO:0006695[cholesterol biosynthetic process] GO:0006739[NADP metabolic process] GO:0006740[NADPH regeneration] GO:0006749[glutathione metabolic process] GO:0009051[pentose-phosphate shunt, oxidative branch] GO:0009898[cytoplasmic side of plasma membrane] GO:0010734[negative regulation of protein glutathionylation] GO:0016020[membrane] GO:0016491[oxidoreductase activity] GO:0016614[oxidoreductase activity, acting on CH-OH group of donors] GO:0019322[pentose biosynthetic process] GO:0021762[substantia nigra development] GO:0034451[centriolar satellite] GO:0034599[cellular response to oxidative stress] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043231[intracellular membrane-bounded organelle] GO:0043249[erythrocyte maturation] GO:0046390[ribose phosphate biosynthetic process] GO:0050661[NADP binding] GO:0051156[glucose 6-phosphate metabolic process] GO:0070062[extracellular exosome]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Hematologic diseases Congenital disorders of metabolism Congenital disorders of amino acid metabolism Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Hematologic diseases Congenital disorders of metabolism Congenital disorders of amino acid metabolism Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Hematologic diseases Congenital disorders of metabolism Congenital disorders of amino acid metabolism Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Hematologic diseases Congenital disorders of metabolism Congenital disorders of amino acid metabolism Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004345[glucose-6-phosphate dehydrogenase activity] GO:0006006[glucose metabolic process] GO:0016614[oxidoreductase activity, acting on CH-OH group of donors] GO:0050661[NADP binding]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Hematologic diseases Congenital disorders of metabolism Congenital disorders of amino acid metabolism Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004345[glucose-6-phosphate dehydrogenase activity] GO:0006006[glucose metabolic process] GO:0016614[oxidoreductase activity, acting on CH-OH group of donors] GO:0050661[NADP binding]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Hematologic diseases Congenital disorders of metabolism Congenital disorders of amino acid metabolism Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004345[glucose-6-phosphate dehydrogenase activity] GO:0006006[glucose metabolic process] GO:0016614[oxidoreductase activity, acting on CH-OH group of donors] GO:0050661[NADP binding]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Hematologic diseases Congenital disorders of metabolism Congenital disorders of amino acid metabolism Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004345[glucose-6-phosphate dehydrogenase activity] GO:0006006[glucose metabolic process] GO:0016614[oxidoreductase activity, acting on CH-OH group of donors] GO:0050661[NADP binding]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Hematologic diseases Congenital disorders of metabolism Congenital disorders of amino acid metabolism Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004345[glucose-6-phosphate dehydrogenase activity] GO:0005829[cytosol] GO:0005975[carbohydrate metabolic process] GO:0006006[glucose metabolic process] GO:0006098[pentose-phosphate shunt] GO:0016491[oxidoreductase activity] GO:0016614[oxidoreductase activity, acting on CH-OH group of donors] GO:0034451[centriolar satellite] GO:0043231[intracellular membrane-bounded organelle] GO:0050661[NADP binding]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Hematologic diseases Congenital disorders of metabolism Congenital disorders of amino acid metabolism Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004345[glucose-6-phosphate dehydrogenase activity] GO:0005829[cytosol] GO:0005975[carbohydrate metabolic process] GO:0006006[glucose metabolic process] GO:0006098[pentose-phosphate shunt] GO:0016491[oxidoreductase activity] GO:0016614[oxidoreductase activity, acting on CH-OH group of donors] GO:0034451[centriolar satellite] GO:0043231[intracellular membrane-bounded organelle] GO:0050661[NADP binding]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Hematologic diseases Congenital disorders of metabolism Congenital disorders of amino acid metabolism Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006006[glucose metabolic process] GO:0016614[oxidoreductase activity, acting on CH-OH group of donors] GO:0050661[NADP binding]
The Human Protein Atlas project is funded
