Expression of CSTB in urothelial cancer

BLADDER UROTHELIAL CARCINOMA (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

CSTB is not prognostic in Bladder Urothelial Carcinoma (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 2056

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average pTPM

1903.0

Number of samples

169

Samples

Sample	Description	pTPM
TCGA-BT-A3PH-01A	76 years, male, white, stage:Stage IV, dead, 142 days	10329.2
TCGA-ZF-A9RE-01A	78 years, female, white, stage:Stage II, dead, 106 days	9024.3
TCGA-G2-A2ES-01A	85 years, male, white, stage:Stage II, dead, 1004 days	7629.0
TCGA-BT-A0YX-01A	70 years, female, white, stage:Stage III, dead, 400 days	6498.3
TCGA-G2-A3IB-01A	66 years, male, black or african american, stage:Stage II, dead, 220 days	6062.2
TCGA-ZF-AA4U-01A	70 years, male, white, stage:Stage III, dead, 262 days	5408.4
TCGA-CU-A5W6-01A	70 years, male, white, stage:Stage III, dead, 56 days	5101.6
TCGA-GV-A3QF-01A	79 years, male, white, stage:Stage IV, dead, 617 days	4935.6
TCGA-XF-A9SZ-01A	79 years, male, white, stage:Stage IV, dead, 859 days	4830.0
TCGA-FJ-A3ZE-01A	65 years, male, white, stage:Stage IV, dead, 324 days	4792.2
TCGA-FD-A5C0-01A	61 years, male, white, stage:Stage IV, dead, 550 days	4577.5
TCGA-GU-A42P-01A	72 years, male, white, stage:Stage IV, dead, 332 days	4550.5
TCGA-E5-A4TZ-01A	64 years, male, white, stage:Stage IV, dead, 467 days	4403.4
TCGA-FD-A3N5-01A	69 years, male, black or african american, stage:Stage II, dead, 685 days	4302.4
TCGA-2F-A9KR-01A	59 years, female, stage:Stage III, dead, 3183 days	4266.6
TCGA-ZF-A9R3-01A	53 years, female, white, stage:Stage II, dead, 949 days	4181.0
TCGA-ZF-AA4T-01A	65 years, male, white, stage:Stage IV, dead, 599 days	4145.3
TCGA-BT-A20T-01A	63 years, male, white, stage:Stage IV, dead, 453 days	4018.7
TCGA-DK-A1A3-01A	60 years, male, white, stage:Stage IV, dead, 665 days	3951.0
TCGA-HQ-A5ND-01A	78 years, male, stage:Stage IV, dead, 274 days	3824.5
TCGA-DK-A3IL-01A	79 years, female, white, stage:Stage IV, dead, 413 days	3799.4
TCGA-DK-AA6L-01A	48 years, male, white, stage:Stage IV, dead, 1163 days	3768.4
TCGA-GV-A40E-01A	75 years, male, white, stage:Stage II, dead, 261 days	3454.4
TCGA-FD-A5BX-01A	82 years, male, white, stage:Stage IV, dead, 173 days	3378.9
TCGA-FD-A3B5-01A	86 years, male, black or african american, stage:Stage IV, dead, 272 days	3263.9
TCGA-FJ-A3Z9-01A	72 years, male, white, stage:'--, dead, 385 days	3251.2
TCGA-UY-A78M-01A	81 years, female, asian, stage:Stage IV, dead, 690 days	3121.7
TCGA-BT-A3PK-01A	80 years, male, white, stage:Stage II, dead, 303 days	3119.9
TCGA-GU-A42R-01A	68 years, male, white, stage:Stage IV, dead, 577 days	3114.7
TCGA-4Z-AA7S-01A	66 years, male, black or african american, stage:Stage III, dead, 1064 days	3071.0
TCGA-FD-A3SM-01A	70 years, male, white, stage:Stage IV, dead, 547 days	2987.5
TCGA-BT-A20P-01A	81 years, female, white, stage:Stage III, dead, 544 days	2984.0
TCGA-FD-A6TD-01A	77 years, male, white, stage:Stage III, dead, 386 days	2880.6
TCGA-XF-AAN2-01A	73 years, male, white, stage:Stage II, dead, 1869 days	2868.8
TCGA-CF-A9FL-01A	85 years, male, asian, stage:Stage III, dead, 565 days	2860.3
TCGA-BT-A20N-01A	72 years, male, stage:Stage III, dead, 795 days	2804.1
TCGA-CU-A72E-01A	76 years, male, white, stage:Stage IV, dead, 413 days	2758.2
TCGA-FD-A62P-01A	76 years, male, white, stage:Stage II, dead, 191 days	2739.5
TCGA-XF-AAMX-01A	87 years, female, black or african american, stage:Stage III, dead, 206 days	2649.0
TCGA-FD-A6TG-01A	73 years, male, white, stage:Stage IV, dead, 93 days	2606.0
TCGA-CU-A0YN-01A	60 years, male, white, stage:Stage III, dead, 393 days	2488.5
TCGA-GV-A3QH-01A	67 years, male, white, stage:Stage II, dead, 258 days	2431.3
TCGA-5N-A9KI-01A	76 years, female, white, stage:Stage III, dead, 76 days	2408.3
TCGA-E7-A541-01A	66 years, male, white, stage:Stage II, dead, 778 days	2391.1
TCGA-XF-A9T8-01A	64 years, male, white, stage:Stage III, dead, 418 days	2337.4
TCGA-XF-A8HH-01A	61 years, female, white, stage:Stage IV, dead, 57 days	2336.0
TCGA-E7-A97P-01A	73 years, male, asian, stage:Stage II, dead, 437 days	2323.3
TCGA-XF-AAML-01A	75 years, male, white, stage:Stage II, dead, 232 days	2299.4
TCGA-XF-A8HI-01A	57 years, female, white, stage:Stage IV, dead, 544 days	2278.0
TCGA-XF-A9SJ-01A	83 years, male, white, stage:Stage IV, dead, 98 days	2235.3
TCGA-GU-AATO-01A	75 years, male, white, stage:Stage IV, dead, 324 days	2223.0
TCGA-5N-A9KM-01A	73 years, female, white, stage:Stage III, dead, 530 days	2202.2
TCGA-ZF-AA5N-01A	62 years, female, white, stage:Stage IV, dead, 168 days	2157.5
TCGA-DK-A3IM-01A	76 years, male, white, stage:Stage III, dead, 248 days	2145.4
TCGA-FD-A62O-01A	74 years, male, white, stage:Stage IV, dead, 216 days	2056.0
TCGA-XF-A8HF-01A	80 years, male, white, stage:Stage III, dead, 2954 days	1981.7
TCGA-ZF-AA52-01A	70 years, male, white, stage:Stage III, dead, 1077 days	1974.6
TCGA-CU-A0YR-01A	83 years, male, white, stage:Stage IV, dead, 460 days	1921.5
TCGA-4Z-AA81-01A	80 years, male, white, stage:Stage II, dead, 1270 days	1918.9
TCGA-HQ-A5NE-01A	57 years, male, stage:Stage III, dead, 370 days	1907.1
TCGA-4Z-AA7Q-01A	79 years, male, white, stage:Stage III, dead, 510 days	1888.3
TCGA-4Z-AA80-01A	73 years, male, white, stage:Stage II, dead, 19 days	1878.4
TCGA-E7-A4XJ-01A	66 years, male, asian, stage:Stage II, dead, 68 days	1864.1
TCGA-E7-A3X6-01A	70 years, male, white, stage:Stage II, dead, 904 days	1850.0
TCGA-ZF-AA56-01A	79 years, female, white, stage:Stage III, dead, 259 days	1847.0
TCGA-G2-A2EO-01A	69 years, male, white, stage:Stage III, dead, 1804 days	1839.3
TCGA-DK-AA75-01A	82 years, male, white, stage:Stage III, dead, 340 days	1826.1
TCGA-G2-A3IE-01A	51 years, male, white, stage:Stage II, dead, 612 days	1751.7
TCGA-FD-A3B3-01A	74 years, female, white, stage:Stage III, dead, 974 days	1749.4
TCGA-DK-A2I2-01A	63 years, female, white, stage:Stage IV, dead, 237 days	1748.4
TCGA-4Z-AA7R-01A	73 years, male, black or african american, stage:Stage IV, dead, 522 days	1739.5
TCGA-XF-AAN1-01A	75 years, female, stage:Stage III, dead, 941 days	1731.2
TCGA-ZF-A9RN-01A	67 years, female, white, stage:Stage III, dead, 615 days	1728.8
TCGA-BL-A13J-01A	65 years, male, white, stage:Stage IV, dead, 81 days	1666.7
TCGA-XF-A8HG-01A	69 years, male, white, stage:Stage III, dead, 467 days	1638.7
TCGA-XF-A9SK-01A	65 years, male, white, stage:Stage IV, dead, 486 days	1627.1
TCGA-XF-AAMZ-01A	81 years, female, white, stage:Stage IV, dead, 1348 days	1610.1
TCGA-CF-A47T-01A	58 years, female, asian, stage:Stage II, dead, 385 days	1566.6
TCGA-GU-A767-01A	81 years, male, white, stage:Stage IV, dead, 144 days	1565.1
TCGA-2F-A9KP-01A	66 years, male, white, stage:Stage IV, dead, 364 days	1547.8
TCGA-XF-A9SV-01A	82 years, male, white, stage:Stage IV, dead, 388 days	1532.2
TCGA-UY-A78N-01A	80 years, male, white, stage:Stage IV, dead, 2641 days	1513.8
TCGA-FD-A3B4-01A	55 years, female, black or african american, stage:Stage III, dead, 510 days	1477.6
TCGA-XF-A9SU-01A	74 years, female, white, stage:Stage IV, dead, 182 days	1465.8
TCGA-FD-A3SJ-01A	59 years, male, white, stage:Stage IV, dead, 739 days	1460.0
TCGA-2F-A9KW-01A	67 years, female, white, stage:Stage III, dead, 254 days	1413.6
TCGA-FD-A5BZ-01A	77 years, female, white, stage:Stage IV, dead, 835 days	1400.6
TCGA-2F-A9KO-01A	63 years, male, white, stage:Stage IV, dead, 734 days	1396.4
TCGA-FD-A6TH-01A	63 years, male, white, stage:Stage IV, dead, 131 days	1362.4
TCGA-FD-A3SQ-01A	62 years, male, white, stage:Stage IV, dead, 1423 days	1330.6
TCGA-UY-A78K-01A	60 years, male, white, stage:Stage IV, dead, 536 days	1309.3
TCGA-FD-A3B7-01A	66 years, male, black or african american, stage:Stage III, dead, 122 days	1298.2
TCGA-BT-A20W-01A	71 years, male, white, stage:Stage II, dead, 254 days	1293.7
TCGA-DK-A1A5-01A	79 years, male, white, stage:Stage II, dead, 65 days	1291.1
TCGA-BT-A2LB-01A	73 years, female, white, stage:Stage III, dead, 492 days	1266.4
TCGA-BT-A20X-01A	56 years, male, white, stage:Stage IV, dead, 251 days	1259.7
TCGA-ZF-A9R9-01A	58 years, male, white, stage:Stage IV, dead, 864 days	1247.5
TCGA-DK-A3IK-01A	87 years, male, white, stage:Stage IV, dead, 146 days	1243.0
TCGA-S5-A6DX-01A	83 years, male, white, stage:Stage IV, dead, 56 days	1239.4
TCGA-ZF-A9RD-01A	75 years, female, white, stage:Stage IV, dead, 408 days	1238.8
TCGA-XF-A9ST-01A	68 years, male, white, stage:Stage III, dead, 128 days	1224.5
TCGA-XF-A8HC-01A	79 years, male, asian, stage:Stage IV, dead, 200 days	1167.1
TCGA-FD-A3SR-01A	68 years, male, white, stage:Stage IV, dead, 602 days	1143.4
TCGA-FD-A3SO-01A	68 years, male, white, stage:Stage IV, dead, 168 days	1142.8
TCGA-GC-A3BM-01A	70 years, male, white, stage:Stage II, dead, 651 days	1138.9
TCGA-ZF-A9R0-01A	82 years, male, white, stage:Stage III, dead, 680 days	1137.2
TCGA-FD-A6TI-01A	73 years, male, white, stage:Stage IV, dead, 294 days	1097.6
TCGA-XF-AAMJ-01A	70 years, male, asian, stage:Stage III, dead, 1670 days	1093.4
TCGA-SY-A9G0-01A	82 years, male, white, stage:Stage IV, dead, 1008 days	1057.5
TCGA-XF-A9SW-01A	85 years, male, white, stage:Stage IV, dead, 362 days	1044.5
TCGA-GU-AATQ-01A	68 years, male, white, stage:Stage III, dead, 213 days	1041.8
TCGA-BT-A20Q-01A	73 years, male, white, stage:Stage IV, dead, 593 days	1037.8
TCGA-FD-A3SL-01A	60 years, male, white, stage:Stage IV, dead, 712 days	1027.9
TCGA-FJ-A871-01A	49 years, male, white, stage:Stage III, dead, 272 days	957.7
TCGA-DK-A3IN-01A	72 years, male, white, stage:Stage III, dead, 250 days	954.8
TCGA-DK-AA6Q-01A	61 years, female, white, stage:Stage IV, dead, 413 days	935.6
TCGA-XF-AAN0-01A	68 years, male, white, stage:Stage IV, dead, 1718 days	924.4
TCGA-DK-A3X2-01A	85 years, male, white, stage:Stage IV, dead, 547 days	913.8
TCGA-FD-A3B6-01A	75 years, male, white, stage:Stage II, dead, 1005 days	903.2
TCGA-XF-A9SH-01A	65 years, female, asian, stage:Stage II, dead, 1971 days	882.9
TCGA-FD-A3SS-01A	66 years, male, white, stage:Stage IV, dead, 391 days	877.7
TCGA-GV-A3JV-01A	66 years, male, white, stage:Stage IV, dead, 434 days	856.6
TCGA-CU-A0YO-01A	84 years, male, white, stage:Stage IV, dead, 149 days	837.5
TCGA-ZF-AA4R-01A	67 years, male, white, stage:Stage IV, dead, 1036 days	835.7
TCGA-G2-A2EC-01A	58 years, female, black or african american, stage:Stage II, dead, 696 days	824.9
TCGA-FD-A43Y-01A	65 years, male, white, stage:Stage III, dead, 474 days	817.6
TCGA-BT-A20U-01A	70 years, female, white, stage:Stage III, dead, 455 days	813.9
TCGA-4Z-AA86-01A	66 years, male, black or african american, stage:Stage IV, dead, 311 days	806.7
TCGA-XF-AAMW-01A	79 years, female, white, stage:Stage IV, dead, 253 days	802.7
TCGA-FD-A5BV-01A	47 years, female, white, stage:Stage III, dead, 163 days	795.0
TCGA-DK-A1AB-01A	74 years, female, white, stage:Stage IV, dead, 508 days	752.9
TCGA-K4-A4AC-01A	83 years, male, white, stage:Stage II, dead, 278 days	726.5
TCGA-BT-A2LD-01A	78 years, female, white, stage:Stage IV, dead, 623 days	702.9
TCGA-DK-A2HX-01A	80 years, female, white, stage:Stage IV, dead, 1420 days	696.0
TCGA-YC-A9TC-01A	71 years, male, white, stage:Stage IV, dead, 20 days	694.4
TCGA-GU-A762-01A	87 years, male, white, stage:Stage IV, dead, 232 days	687.2
TCGA-G2-AA3C-01A	66 years, male, white, stage:Stage IV, dead, 211 days	675.5
TCGA-DK-AA6W-01A	78 years, male, white, stage:Stage II, dead, 415 days	674.5
TCGA-BT-A20V-01A	59 years, female, black or african american, stage:Stage IV, dead, 154 days	650.9
TCGA-XF-AAMT-01A	75 years, female, white, stage:Stage IV, dead, 90 days	647.1
TCGA-FD-A62S-01A	60 years, female, black or african american, stage:Stage III, dead, 406 days	603.9
TCGA-GU-A42Q-01A	67 years, male, white, stage:Stage III, dead, 344 days	583.1
TCGA-4Z-AA7N-01A	65 years, male, white, stage:Stage III, dead, 1367 days	575.5
TCGA-DK-A3IU-01A	58 years, male, white, stage:Stage II, dead, 706 days	567.7
TCGA-XF-A9SL-01A	69 years, male, white, stage:Stage IV, dead, 2020 days	566.1
TCGA-FD-A5BT-01A	84 years, male, white, stage:Stage III, dead, 328 days	555.7
TCGA-GC-A3I6-01A	45 years, male, white, stage:Stage III, dead, 630 days	545.1
TCGA-XF-A9SX-01A	63 years, female, white, stage:Stage IV, dead, 719 days	511.7
TCGA-XF-AAME-01A	64 years, female, white, stage:Stage II, dead, 2828 days	491.7
TCGA-XF-A9T2-01A	54 years, male, white, stage:Stage III, dead, 575 days	448.0
TCGA-XF-A9SP-01A	59 years, male, white, stage:Stage III, dead, 454 days	446.1
TCGA-4Z-AA82-01A	59 years, male, black or african american, stage:Stage IV, dead, 1556 days	439.7
TCGA-XF-AAMH-01A	80 years, male, white, stage:Stage IV, dead, 344 days	422.5
TCGA-ZF-AA4N-01A	74 years, male, white, stage:Stage II, dead, 88 days	420.7
TCGA-XF-AAN8-01A	74 years, female, white, stage:Stage III, dead, 118 days	417.6
TCGA-BT-A20O-01A	75 years, male, white, stage:Stage III, dead, 370 days	406.7
TCGA-C4-A0EZ-01A	69 years, female, stage:Stage IV, dead, 273 days	399.4
TCGA-BT-A20J-01A	75 years, male, white, stage:Stage II, dead, 579 days	372.9
TCGA-C4-A0F7-01A	77 years, male, stage:Stage IV, dead, 62 days	370.0
TCGA-DK-A3IQ-01A	74 years, male, white, stage:Stage III, dead, 539 days	350.4
TCGA-K4-A5RI-01A	67 years, female, white, stage:Stage III, dead, 356 days	337.8
TCGA-FD-A6TF-01A	80 years, female, white, stage:Stage IV, dead, 69 days	319.8
TCGA-ZF-AA54-01A	71 years, male, white, stage:Stage III, dead, 590 days	264.2
TCGA-G2-A2EL-01A	77 years, male, white, stage:Stage II, dead, 819 days	243.1
TCGA-XF-AAN4-01A	77 years, female, white, stage:Stage III, dead, 823 days	238.8
TCGA-BT-A0S7-01A	75 years, male, white, stage:Stage III, dead, 200 days	201.8
TCGA-BL-A3JM-01A	62 years, male, white, stage:Stage III, dead, 205 days	190.3
TCGA-XF-AAN7-01A	60 years, male, white, stage:Stage IV, dead, 565 days	178.8
TCGA-BL-A13I-01A	57 years, female, white, stage:Stage III, dead, 223 days	104.0
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UROTHELIAL CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.	Antibody HPA017380	Antibody HPA058557	Antibody CAB047320
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Urothelial carcinoma, Low grade
Urothelial carcinoma, High grade
Urothelial carcinoma, NOS