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SLC2A6
HPA
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  • SLC2A6
PROTEIN SUMMARY GENE INFORMATION RNA DATA ANTIBODY DATA
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

SLC2A6
Synonyms GLUT6, GLUT9, HSA011372
Gene descriptioni

Full gene name according to HGNC.

Solute carrier family 2 member 6
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Metabolic proteins
Transporters
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Membrane
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 9
Cytoband q34.2
Chromosome location (bp) 133471094 - 133479127
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

4
Ensembl ENSG00000160326 (version 109)
Entrez gene 11182
HGNC HGNC:11011
UniProt Q9UGQ3 (UniProt - Evidence at protein level)
neXtProt NX_Q9UGQ3
GeneCards SLC2A6
Antibodypedia SLC2A6 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i

Useful information about the protein provided by UniProt.

Probable sugar transporter that acts as a regulator of glycolysis in macrophages (Probable). Does not transport glucose 1.... show less
Biological process (UniProt)i

Keywords assigned by UniProt to proteins because they are involved in a particular biological process.

Sugar transport, Transport
Gene summary (Entrez)i

Useful information about the gene from Entrez

Hexose transport into mammalian cells is catalyzed by a family of membrane proteins, including SLC2A6, that contain 12 transmembrane domains and a number of critical conserved residues.[supplied by OMIM, Jul 2002]... show less
PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
SLC2A6-201
ENSP00000360964
ENST00000371897
Q9UGQ3
[Direct mapping] Solute carrier family 2, facilitated glucose transporter member 6
Show all
Metabolic proteins
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0005353 [fructose transmembrane transporter activity]
GO:0005355 [glucose transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0006110 [regulation of glycolytic process]
GO:0008643 [carbohydrate transport]
GO:0008645 [hexose transmembrane transport]
GO:0015755 [fructose transmembrane transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0033300 [dehydroascorbic acid transmembrane transporter activity]
GO:0055056 [D-glucose transmembrane transporter activity]
GO:0055085 [transmembrane transport]
GO:0070837 [dehydroascorbic acid transport]
GO:1904659 [glucose transmembrane transport]
Show all
445 aa
48 kDa
No >9
SLC2A6-202
ENSP00000360966
ENST00000371899
Q9UGQ3
[Direct mapping] Solute carrier family 2, facilitated glucose transporter member 6
Show all
Metabolic proteins
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0005353 [fructose transmembrane transporter activity]
GO:0005355 [glucose transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0006110 [regulation of glycolytic process]
GO:0008643 [carbohydrate transport]
GO:0008645 [hexose transmembrane transport]
GO:0015755 [fructose transmembrane transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0033300 [dehydroascorbic acid transmembrane transporter activity]
GO:0055056 [D-glucose transmembrane transporter activity]
GO:0055085 [transmembrane transport]
GO:0070837 [dehydroascorbic acid transport]
GO:1904659 [glucose transmembrane transport]
Show all
507 aa
54.5 kDa
No >9
SLC2A6-203
ENSP00000398004
ENST00000414172
F2Z3K7
[Direct mapping] Solute carrier family 2, facilitated glucose transporter member 6
Show all
Metabolic proteins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0055085 [transmembrane transport]
Show all
146 aa
15.4 kDa
No 2
SLC2A6-204
ENSP00000405124
ENST00000432868
F2Z2F6
[Direct mapping] Solute carrier family 2, facilitated glucose transporter member 6
Show all
Metabolic proteins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0055085 [transmembrane transport]
Show all
219 aa
22.7 kDa
No 4

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