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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q21.3
Chromosome location (bp)
154962298 - 154974395
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P29353 [Direct mapping] SHC-transforming protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001525[angiogenesis] GO:0001784[phosphotyrosine residue binding] GO:0005068[transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005154[epidermal growth factor receptor binding] GO:0005158[insulin receptor binding] GO:0005159[insulin-like growth factor receptor binding] GO:0005168[neurotrophin TRKA receptor binding] GO:0005515[protein binding] GO:0005543[phospholipid binding] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007176[regulation of epidermal growth factor-activated receptor activity] GO:0008284[positive regulation of cell population proliferation] GO:0008286[insulin receptor signaling pathway] GO:0016525[negative regulation of angiogenesis] GO:0019901[protein kinase binding] GO:0030971[receptor tyrosine kinase binding] GO:0035556[intracellular signal transduction] GO:0042742[defense response to bacterium] GO:0043066[negative regulation of apoptotic process] GO:0043410[positive regulation of MAPK cascade] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0046875[ephrin receptor binding] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070435[Shc-EGFR complex] GO:0071363[cellular response to growth factor stimulus] GO:0071864[positive regulation of cell proliferation in bone marrow] GO:0090322[regulation of superoxide metabolic process]
X6R6D0 [Direct mapping] SHC-transforming protein 1
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Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)
P29353 [Direct mapping] SHC-transforming protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001525[angiogenesis] GO:0001784[phosphotyrosine residue binding] GO:0005068[transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005154[epidermal growth factor receptor binding] GO:0005158[insulin receptor binding] GO:0005159[insulin-like growth factor receptor binding] GO:0005168[neurotrophin TRKA receptor binding] GO:0005515[protein binding] GO:0005543[phospholipid binding] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007176[regulation of epidermal growth factor-activated receptor activity] GO:0008284[positive regulation of cell population proliferation] GO:0008286[insulin receptor signaling pathway] GO:0019901[protein kinase binding] GO:0030971[receptor tyrosine kinase binding] GO:0035556[intracellular signal transduction] GO:0042742[defense response to bacterium] GO:0043066[negative regulation of apoptotic process] GO:0043410[positive regulation of MAPK cascade] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0046875[ephrin receptor binding] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070435[Shc-EGFR complex] GO:0071363[cellular response to growth factor stimulus]
P29353 [Direct mapping] SHC-transforming protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001525[angiogenesis] GO:0001784[phosphotyrosine residue binding] GO:0005068[transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005154[epidermal growth factor receptor binding] GO:0005158[insulin receptor binding] GO:0005159[insulin-like growth factor receptor binding] GO:0005168[neurotrophin TRKA receptor binding] GO:0005515[protein binding] GO:0005543[phospholipid binding] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007176[regulation of epidermal growth factor-activated receptor activity] GO:0008284[positive regulation of cell population proliferation] GO:0008286[insulin receptor signaling pathway] GO:0019901[protein kinase binding] GO:0030971[receptor tyrosine kinase binding] GO:0035556[intracellular signal transduction] GO:0042742[defense response to bacterium] GO:0043066[negative regulation of apoptotic process] GO:0043410[positive regulation of MAPK cascade] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0046875[ephrin receptor binding] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070435[Shc-EGFR complex] GO:0071363[cellular response to growth factor stimulus]
Q5T188 [Direct mapping] SHC-transforming protein 1
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SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)
Q5T187 [Direct mapping] SHC-transforming protein 1
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Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)
P29353 [Direct mapping] SHC-transforming protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0001784[phosphotyrosine residue binding] GO:0005068[transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005154[epidermal growth factor receptor binding] GO:0005158[insulin receptor binding] GO:0005159[insulin-like growth factor receptor binding] GO:0005168[neurotrophin TRKA receptor binding] GO:0005515[protein binding] GO:0005543[phospholipid binding] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007176[regulation of epidermal growth factor-activated receptor activity] GO:0007507[heart development] GO:0008284[positive regulation of cell population proliferation] GO:0008286[insulin receptor signaling pathway] GO:0019901[protein kinase binding] GO:0030971[receptor tyrosine kinase binding] GO:0031532[actin cytoskeleton reorganization] GO:0035556[intracellular signal transduction] GO:0042127[regulation of cell population proliferation] GO:0042742[defense response to bacterium] GO:0043066[negative regulation of apoptotic process] GO:0043410[positive regulation of MAPK cascade] GO:0043539[protein serine/threonine kinase activator activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0046875[ephrin receptor binding] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048408[epidermal growth factor binding] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070435[Shc-EGFR complex] GO:0071363[cellular response to growth factor stimulus] GO:0098609[cell-cell adhesion]
The Human Protein Atlas project is funded
