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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Candidate cardiovascular disease genes CD markers Disease related genes FDA approved drug targets Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q21.3
Chromosome location (bp)
154405193 - 154469450
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal 1. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis 2,3. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Receptor
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, Aug 2020]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
CD markers MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002384[hepatic immune response] GO:0002548[monocyte chemotaxis] GO:0002690[positive regulation of leukocyte chemotaxis] GO:0004896[cytokine receptor activity] GO:0004897[ciliary neurotrophic factor receptor activity] GO:0004915[interleukin-6 receptor activity] GO:0004921[interleukin-11 receptor activity] GO:0005138[interleukin-6 receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005886[plasma membrane] GO:0005896[interleukin-6 receptor complex] GO:0006953[acute-phase response] GO:0008284[positive regulation of cell population proliferation] GO:0009897[external side of plasma membrane] GO:0010033[response to organic substance] GO:0010536[positive regulation of activation of Janus kinase activity] GO:0010573[vascular endothelial growth factor production] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0019221[cytokine-mediated signaling pathway] GO:0019899[enzyme binding] GO:0019955[cytokine binding] GO:0019970[interleukin-11 binding] GO:0019981[interleukin-6 binding] GO:0031018[endocrine pancreas development] GO:0032722[positive regulation of chemokine production] GO:0032755[positive regulation of interleukin-6 production] GO:0032966[negative regulation of collagen biosynthetic process] GO:0034097[response to cytokine] GO:0038154[interleukin-11-mediated signaling pathway] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0042803[protein homodimerization activity] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0045669[positive regulation of osteoblast differentiation] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050829[defense response to Gram-negative bacterium] GO:0070102[interleukin-6-mediated signaling pathway] GO:0070110[ciliary neurotrophic factor receptor complex] GO:0070119[ciliary neurotrophic factor binding] GO:0070120[ciliary neurotrophic factor-mediated signaling pathway] GO:0072126[positive regulation of glomerular mesangial cell proliferation] GO:0097191[extrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
