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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
Chromosome location (bp)
39757718 - 39864312
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9UKT9 [Direct mapping] Zinc finger protein Aiolos
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007498[mesoderm development] GO:0030888[regulation of B cell proliferation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0045577[regulation of B cell differentiation] GO:0045619[regulation of lymphocyte differentiation] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:1990841[promoter-specific chromatin binding]
Q9UKT9 [Direct mapping] Zinc finger protein Aiolos
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007498[mesoderm development] GO:0009617[response to bacterium] GO:0030183[B cell differentiation] GO:0030217[T cell differentiation] GO:0030888[regulation of B cell proliferation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0045577[regulation of B cell differentiation] GO:0045619[regulation of lymphocyte differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:1990841[promoter-specific chromatin binding]
Q9UKT9 [Direct mapping] Zinc finger protein Aiolos
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007498[mesoderm development] GO:0030888[regulation of B cell proliferation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0045577[regulation of B cell differentiation] GO:0045619[regulation of lymphocyte differentiation] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:1990841[promoter-specific chromatin binding]
Q9UKT9 [Direct mapping] Zinc finger protein Aiolos
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007498[mesoderm development] GO:0030888[regulation of B cell proliferation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0045577[regulation of B cell differentiation] GO:0045619[regulation of lymphocyte differentiation] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:1990841[promoter-specific chromatin binding]
Q9UKT9 [Direct mapping] Zinc finger protein Aiolos
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007498[mesoderm development] GO:0030888[regulation of B cell proliferation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0045577[regulation of B cell differentiation] GO:0045619[regulation of lymphocyte differentiation] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:1990841[promoter-specific chromatin binding]
Q9UKT9 [Direct mapping] Zinc finger protein Aiolos
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007498[mesoderm development] GO:0030888[regulation of B cell proliferation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0045577[regulation of B cell differentiation] GO:0045619[regulation of lymphocyte differentiation] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:1990841[promoter-specific chromatin binding]
Q9UKT9 [Direct mapping] Zinc finger protein Aiolos
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007498[mesoderm development] GO:0030888[regulation of B cell proliferation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0045577[regulation of B cell differentiation] GO:0045619[regulation of lymphocyte differentiation] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:1990841[promoter-specific chromatin binding]
Q9UKT9 [Direct mapping] Zinc finger protein Aiolos
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007498[mesoderm development] GO:0030888[regulation of B cell proliferation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0045577[regulation of B cell differentiation] GO:0045619[regulation of lymphocyte differentiation] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:1990841[promoter-specific chromatin binding]
Q9UKT9 [Direct mapping] Zinc finger protein Aiolos
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007498[mesoderm development] GO:0030888[regulation of B cell proliferation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0045577[regulation of B cell differentiation] GO:0045619[regulation of lymphocyte differentiation] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:1990841[promoter-specific chromatin binding]
Q9UKT9 [Direct mapping] Zinc finger protein Aiolos
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007498[mesoderm development] GO:0030888[regulation of B cell proliferation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0045577[regulation of B cell differentiation] GO:0045619[regulation of lymphocyte differentiation] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:1990841[promoter-specific chromatin binding]
Q9UKT9 [Direct mapping] Zinc finger protein Aiolos
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007498[mesoderm development] GO:0030888[regulation of B cell proliferation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0045577[regulation of B cell differentiation] GO:0045619[regulation of lymphocyte differentiation] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:1990841[promoter-specific chromatin binding]
Q9UKT9 [Direct mapping] Zinc finger protein Aiolos
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007498[mesoderm development] GO:0030888[regulation of B cell proliferation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0045577[regulation of B cell differentiation] GO:0045619[regulation of lymphocyte differentiation] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:1990841[promoter-specific chromatin binding]
Q9UKT9 [Direct mapping] Zinc finger protein Aiolos
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007498[mesoderm development] GO:0030888[regulation of B cell proliferation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0045577[regulation of B cell differentiation] GO:0045619[regulation of lymphocyte differentiation] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:1990841[promoter-specific chromatin binding]
Q9UKT9 [Direct mapping] Zinc finger protein Aiolos
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007498[mesoderm development] GO:0030888[regulation of B cell proliferation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0045577[regulation of B cell differentiation] GO:0045619[regulation of lymphocyte differentiation] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:1990841[promoter-specific chromatin binding]
Q9UKT9 [Direct mapping] Zinc finger protein Aiolos
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007498[mesoderm development] GO:0030888[regulation of B cell proliferation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0045577[regulation of B cell differentiation] GO:0045619[regulation of lymphocyte differentiation] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:1990841[promoter-specific chromatin binding]
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