We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p35.2
Chromosome location (bp)
30732469 - 30757774
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May have a special functional role during embryogenesis and in adult hematopoietic cells....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transport
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. [provided by RefSeq, Feb 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q13571 [Direct mapping] Lysosomal-associated transmembrane protein 5
Show all
Q5TBB8 [Target identity:100%; Query identity:100%] Lysosomal associated multispanning membrane protein 5, isoform CRA_a; Lysosomal multispanning membrane protein 5; cDNA FLJ75768, highly similar to Homo sapiens lysosomal associated multispanning membrane protein 5 (LAPTM5), mRNA
Show all
Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0002357[defense response to tumor cell] GO:0002720[positive regulation of cytokine production involved in immune response] GO:0005515[protein binding] GO:0005764[lysosome] GO:0005765[lysosomal membrane] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006622[protein targeting to lysosome] GO:0006886[intracellular protein transport] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0012502[induction of programmed cell death] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0030133[transport vesicle] GO:0031398[positive regulation of protein ubiquitination] GO:0031410[cytoplasmic vesicle] GO:0031625[ubiquitin protein ligase binding] GO:0032689[negative regulation of interferon-gamma production] GO:0032703[negative regulation of interleukin-2 production] GO:0032735[positive regulation of interleukin-12 production] GO:0032991[protein-containing complex] GO:0043410[positive regulation of MAPK cascade] GO:0048471[perinuclear region of cytoplasm] GO:0050860[negative regulation of T cell receptor signaling pathway] GO:0050868[negative regulation of T cell activation] GO:0050869[negative regulation of B cell activation] GO:0060907[positive regulation of macrophage cytokine production] GO:0090160[Golgi to lysosome transport] GO:0097214[positive regulation of lysosomal membrane permeability] GO:0110165[cellular anatomical entity] GO:0140036[ubiquitin-dependent protein binding] GO:0140311[protein sequestering activity] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:1903265[positive regulation of tumor necrosis factor-mediated signaling pathway] GO:1904093[negative regulation of autophagic cell death] GO:2000060[positive regulation of ubiquitin-dependent protein catabolic process] GO:2000646[positive regulation of receptor catabolic process]
The Human Protein Atlas project is funded
