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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p31.3
Chromosome location (bp)
67138907 - 67259979
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Immunity, Inflammatory response, Innate immunity
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Human disease related genes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) DeepTMHMM predicted membrane proteins
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GO:0001916[positive regulation of T cell mediated cytotoxicity] GO:0002230[positive regulation of defense response to virus by host] GO:0002376[immune system process] GO:0002827[positive regulation of T-helper 1 type immune response] GO:0004896[cytokine receptor activity] GO:0005143[interleukin-12 receptor binding] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0006954[inflammatory response] GO:0009897[external side of plasma membrane] GO:0010536[positive regulation of activation of Janus kinase activity] GO:0016020[membrane] GO:0019221[cytokine-mediated signaling pathway] GO:0019955[cytokine binding] GO:0032496[response to lipopolysaccharide] GO:0032693[negative regulation of interleukin-10 production] GO:0032725[positive regulation of granulocyte macrophage colony-stimulating factor production] GO:0032729[positive regulation of interferon-gamma production] GO:0032735[positive regulation of interleukin-12 production] GO:0032740[positive regulation of interleukin-17 production] GO:0032819[positive regulation of natural killer cell proliferation] GO:0034341[response to type II interferon] GO:0038155[interleukin-23-mediated signaling pathway] GO:0042019[interleukin-23 binding] GO:0042020[interleukin-23 receptor activity] GO:0042102[positive regulation of T cell proliferation] GO:0042104[positive regulation of activated T cell proliferation] GO:0042509[regulation of tyrosine phosphorylation of STAT protein] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0043235[receptor complex] GO:0043382[positive regulation of memory T cell differentiation] GO:0045087[innate immune response] GO:0045672[positive regulation of osteoclast differentiation] GO:0050829[defense response to Gram-negative bacterium] GO:0051135[positive regulation of NK T cell activation] GO:0072536[interleukin-23 receptor complex] GO:2000318[positive regulation of T-helper 17 type immune response] GO:2000330[positive regulation of T-helper 17 cell lineage commitment]
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Human disease related genes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level DeepTMHMM predicted membrane proteins
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GO:0001916[positive regulation of T cell mediated cytotoxicity] GO:0002230[positive regulation of defense response to virus by host] GO:0002376[immune system process] GO:0002827[positive regulation of T-helper 1 type immune response] GO:0004896[cytokine receptor activity] GO:0005143[interleukin-12 receptor binding] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0006954[inflammatory response] GO:0009897[external side of plasma membrane] GO:0010536[positive regulation of activation of Janus kinase activity] GO:0016020[membrane] GO:0019221[cytokine-mediated signaling pathway] GO:0019955[cytokine binding] GO:0032496[response to lipopolysaccharide] GO:0032693[negative regulation of interleukin-10 production] GO:0032725[positive regulation of granulocyte macrophage colony-stimulating factor production] GO:0032729[positive regulation of interferon-gamma production] GO:0032735[positive regulation of interleukin-12 production] GO:0032740[positive regulation of interleukin-17 production] GO:0032819[positive regulation of natural killer cell proliferation] GO:0034341[response to type II interferon] GO:0038155[interleukin-23-mediated signaling pathway] GO:0042019[interleukin-23 binding] GO:0042020[interleukin-23 receptor activity] GO:0042102[positive regulation of T cell proliferation] GO:0042104[positive regulation of activated T cell proliferation] GO:0042509[regulation of tyrosine phosphorylation of STAT protein] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0043235[receptor complex] GO:0043382[positive regulation of memory T cell differentiation] GO:0045087[innate immune response] GO:0045672[positive regulation of osteoclast differentiation] GO:0050829[defense response to Gram-negative bacterium] GO:0051135[positive regulation of NK T cell activation] GO:0072536[interleukin-23 receptor complex] GO:2000318[positive regulation of T-helper 17 type immune response] GO:2000330[positive regulation of T-helper 17 cell lineage commitment]
The Human Protein Atlas project is funded
