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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
p22.3
Chromosome location (bp)
33496245 - 33718356
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules 1. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle 3,4. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell cycle, Cell division, Mitosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables cytoskeletal protein binding activity; dystroglycan binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including microtubule cytoskeleton organization; positive regulation of extracellular matrix organization; and regulation of supramolecular fiber organization. Located in several cellular components, including basal cortex; cortical microtubule plus-end; and ruffle membrane. Colocalizes with focal adhesion; kinetochore; and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O75122 [Direct mapping] CLIP-associating protein 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000226[microtubule cytoskeleton organization] GO:0000775[chromosome, centromeric region] GO:0000776[kinetochore] GO:0002162[dystroglycan binding] GO:0005515[protein binding] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005802[trans-Golgi network] GO:0005815[microtubule organizing center] GO:0005819[spindle] GO:0005828[kinetochore microtubule] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005876[spindle microtubule] GO:0005881[cytoplasmic microtubule] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0005938[cell cortex] GO:0006903[vesicle targeting] GO:0007020[microtubule nucleation] GO:0007026[negative regulation of microtubule depolymerization] GO:0007030[Golgi organization] GO:0007049[cell cycle] GO:0007052[mitotic spindle organization] GO:0007163[establishment or maintenance of cell polarity] GO:0008017[microtubule binding] GO:0010458[exit from mitosis] GO:0010470[regulation of gastrulation] GO:0010634[positive regulation of epithelial cell migration] GO:0010717[regulation of epithelial to mesenchymal transition] GO:0016020[membrane] GO:0031023[microtubule organizing center organization] GO:0031110[regulation of microtubule polymerization or depolymerization] GO:0031252[cell leading edge] GO:0032587[ruffle membrane] GO:0032886[regulation of microtubule-based process] GO:0034453[microtubule anchoring] GO:0040001[establishment of mitotic spindle localization] GO:0042995[cell projection] GO:0043232[intracellular non-membrane-bounded organelle] GO:0045180[basal cortex] GO:0045921[positive regulation of exocytosis] GO:0051010[microtubule plus-end binding] GO:0051128[regulation of cellular component organization] GO:0051301[cell division] GO:0051497[negative regulation of stress fiber assembly] GO:0051895[negative regulation of focal adhesion assembly] GO:0072659[protein localization to plasma membrane] GO:0072686[mitotic spindle] GO:0090091[positive regulation of extracellular matrix disassembly] GO:0090307[mitotic spindle assembly] GO:1903690[negative regulation of wound healing, spreading of epidermal cells] GO:1904261[positive regulation of basement membrane assembly involved in embryonic body morphogenesis]
O75122 [Direct mapping] CLIP-associating protein 2
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MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000226[microtubule cytoskeleton organization] GO:0000775[chromosome, centromeric region] GO:0000776[kinetochore] GO:0002162[dystroglycan binding] GO:0005515[protein binding] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005802[trans-Golgi network] GO:0005815[microtubule organizing center] GO:0005819[spindle] GO:0005828[kinetochore microtubule] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005876[spindle microtubule] GO:0005881[cytoplasmic microtubule] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0005938[cell cortex] GO:0006903[vesicle targeting] GO:0007020[microtubule nucleation] GO:0007026[negative regulation of microtubule depolymerization] GO:0007030[Golgi organization] GO:0007049[cell cycle] GO:0007052[mitotic spindle organization] GO:0007163[establishment or maintenance of cell polarity] GO:0008017[microtubule binding] GO:0010458[exit from mitosis] GO:0010470[regulation of gastrulation] GO:0010634[positive regulation of epithelial cell migration] GO:0010717[regulation of epithelial to mesenchymal transition] GO:0016020[membrane] GO:0031023[microtubule organizing center organization] GO:0031110[regulation of microtubule polymerization or depolymerization] GO:0031252[cell leading edge] GO:0032587[ruffle membrane] GO:0032886[regulation of microtubule-based process] GO:0034453[microtubule anchoring] GO:0035791[platelet-derived growth factor receptor-beta signaling pathway] GO:0040001[establishment of mitotic spindle localization] GO:0042995[cell projection] GO:0043232[intracellular non-membrane-bounded organelle] GO:0045180[basal cortex] GO:0045921[positive regulation of exocytosis] GO:0051010[microtubule plus-end binding] GO:0051015[actin filament binding] GO:0051128[regulation of cellular component organization] GO:0051301[cell division] GO:0051497[negative regulation of stress fiber assembly] GO:0051895[negative regulation of focal adhesion assembly] GO:0072659[protein localization to plasma membrane] GO:0072686[mitotic spindle] GO:0090091[positive regulation of extracellular matrix disassembly] GO:0090307[mitotic spindle assembly] GO:1903690[negative regulation of wound healing, spreading of epidermal cells] GO:1904261[positive regulation of basement membrane assembly involved in embryonic body morphogenesis] GO:1990782[protein tyrosine kinase binding]
E7ERI8 [Direct mapping] CLIP-associating protein 2
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MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
E7EW49 [Direct mapping] CLIP-associating protein 2
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MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
H7C4M5 [Direct mapping] CLIP-associating protein 2
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SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
O75122 [Direct mapping] CLIP-associating protein 2
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MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000226[microtubule cytoskeleton organization] GO:0000775[chromosome, centromeric region] GO:0000776[kinetochore] GO:0002162[dystroglycan binding] GO:0005515[protein binding] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005802[trans-Golgi network] GO:0005815[microtubule organizing center] GO:0005819[spindle] GO:0005828[kinetochore microtubule] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005876[spindle microtubule] GO:0005881[cytoplasmic microtubule] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0005938[cell cortex] GO:0006903[vesicle targeting] GO:0007020[microtubule nucleation] GO:0007026[negative regulation of microtubule depolymerization] GO:0007030[Golgi organization] GO:0007049[cell cycle] GO:0007052[mitotic spindle organization] GO:0007163[establishment or maintenance of cell polarity] GO:0008017[microtubule binding] GO:0010458[exit from mitosis] GO:0010470[regulation of gastrulation] GO:0010634[positive regulation of epithelial cell migration] GO:0010717[regulation of epithelial to mesenchymal transition] GO:0016020[membrane] GO:0030516[regulation of axon extension] GO:0031023[microtubule organizing center organization] GO:0031110[regulation of microtubule polymerization or depolymerization] GO:0031113[regulation of microtubule polymerization] GO:0031252[cell leading edge] GO:0032587[ruffle membrane] GO:0032886[regulation of microtubule-based process] GO:0032956[regulation of actin cytoskeleton organization] GO:0034453[microtubule anchoring] GO:0040001[establishment of mitotic spindle localization] GO:0042995[cell projection] GO:0043232[intracellular non-membrane-bounded organelle] GO:0044295[axonal growth cone] GO:0045180[basal cortex] GO:0045921[positive regulation of exocytosis] GO:0051010[microtubule plus-end binding] GO:0051128[regulation of cellular component organization] GO:0051301[cell division] GO:0051497[negative regulation of stress fiber assembly] GO:0051895[negative regulation of focal adhesion assembly] GO:0072659[protein localization to plasma membrane] GO:0072686[mitotic spindle] GO:0090091[positive regulation of extracellular matrix disassembly] GO:0090307[mitotic spindle assembly] GO:1903690[negative regulation of wound healing, spreading of epidermal cells] GO:1903754[cortical microtubule plus-end] GO:1904261[positive regulation of basement membrane assembly involved in embryonic body morphogenesis] GO:1990782[protein tyrosine kinase binding]
B3KR06 [Direct mapping] CLIP-associating protein 2; Cytoplasmic linker associated protein 2, isoform CRA_c; cDNA FLJ33397 fis, clone BRACE2007937, highly similar to CLIP-associating protein 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0043232[intracellular non-membrane-bounded organelle] GO:0051128[regulation of cellular component organization]
A0A0U1RQI6 [Direct mapping] CLIP-associating protein 2
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MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
J3KR49 [Direct mapping] CLIP-associating protein 2
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MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
A0A804HJG7 [Direct mapping] CLIP-associating protein 2
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MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0000776[kinetochore] GO:0005737[cytoplasm] GO:0043232[intracellular non-membrane-bounded organelle] GO:0051128[regulation of cellular component organization]
The Human Protein Atlas project is funded
