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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q23.1
Chromosome location (bp)
158930796 - 158977059
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell cycle
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q6K0P9 [Direct mapping] Pyrin and HIN domain-containing protein 1
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Phobius predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0002218[activation of innate immune response] GO:0003690[double-stranded DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0007049[cell cycle] GO:0016607[nuclear speck] GO:0031625[ubiquitin protein ligase binding] GO:0031648[protein destabilization] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0035457[cellular response to interferon-alpha] GO:0035458[cellular response to interferon-beta] GO:0043388[positive regulation of DNA binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0050821[protein stabilization] GO:1900182[positive regulation of protein localization to nucleus] GO:1902164[positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:2000060[positive regulation of ubiquitin-dependent protein catabolic process]
Q6K0P9 [Direct mapping] Pyrin and HIN domain-containing protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002218[activation of innate immune response] GO:0003690[double-stranded DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0007049[cell cycle] GO:0016607[nuclear speck] GO:0031625[ubiquitin protein ligase binding] GO:0031648[protein destabilization] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0035457[cellular response to interferon-alpha] GO:0035458[cellular response to interferon-beta] GO:0043388[positive regulation of DNA binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0050821[protein stabilization] GO:1900182[positive regulation of protein localization to nucleus] GO:1902164[positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:2000060[positive regulation of ubiquitin-dependent protein catabolic process]
Q6K0P9 [Direct mapping] Pyrin and HIN domain-containing protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002218[activation of innate immune response] GO:0003690[double-stranded DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0007049[cell cycle] GO:0016607[nuclear speck] GO:0031625[ubiquitin protein ligase binding] GO:0031648[protein destabilization] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0035457[cellular response to interferon-alpha] GO:0035458[cellular response to interferon-beta] GO:0043388[positive regulation of DNA binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0050821[protein stabilization] GO:1900182[positive regulation of protein localization to nucleus] GO:1902164[positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:2000060[positive regulation of ubiquitin-dependent protein catabolic process]
Q6K0P9 [Direct mapping] Pyrin and HIN domain-containing protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002218[activation of innate immune response] GO:0003690[double-stranded DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0007049[cell cycle] GO:0016607[nuclear speck] GO:0031625[ubiquitin protein ligase binding] GO:0031648[protein destabilization] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0035457[cellular response to interferon-alpha] GO:0035458[cellular response to interferon-beta] GO:0043388[positive regulation of DNA binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0050821[protein stabilization] GO:1900182[positive regulation of protein localization to nucleus] GO:1902164[positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:2000060[positive regulation of ubiquitin-dependent protein catabolic process]
Q6K0P9 [Direct mapping] Pyrin and HIN domain-containing protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002218[activation of innate immune response] GO:0003690[double-stranded DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0007049[cell cycle] GO:0016607[nuclear speck] GO:0031625[ubiquitin protein ligase binding] GO:0031648[protein destabilization] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0035457[cellular response to interferon-alpha] GO:0035458[cellular response to interferon-beta] GO:0043388[positive regulation of DNA binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0050821[protein stabilization] GO:1900182[positive regulation of protein localization to nucleus] GO:1902164[positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:2000060[positive regulation of ubiquitin-dependent protein catabolic process]
The Human Protein Atlas project is funded
