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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q23.1
Chromosome location (bp)
158999968 - 159055155
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q16666 [Direct mapping] Gamma-interferon-inducible protein 16
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001819[positive regulation of cytokine production] GO:0002218[activation of innate immune response] GO:0002376[immune system process] GO:0003677[DNA binding] GO:0003690[double-stranded DNA binding] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006914[autophagy] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0008134[transcription factor binding] GO:0010506[regulation of autophagy] GO:0016020[membrane] GO:0016607[nuclear speck] GO:0030099[myeloid cell differentiation] GO:0030224[monocyte differentiation] GO:0032731[positive regulation of interleukin-1 beta production] GO:0035458[cellular response to interferon-beta] GO:0040029[epigenetic regulation of gene expression] GO:0042149[cellular response to glucose starvation] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0043392[negative regulation of DNA binding] GO:0045071[negative regulation of viral genome replication] GO:0045087[innate immune response] GO:0045824[negative regulation of innate immune response] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0051607[defense response to virus] GO:0071479[cellular response to ionizing radiation] GO:0072332[intrinsic apoptotic signaling pathway by p53 class mediator] GO:0097202[activation of cysteine-type endopeptidase activity] GO:2000117[negative regulation of cysteine-type endopeptidase activity]
Q16666 [Direct mapping] Gamma-interferon-inducible protein 16
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001819[positive regulation of cytokine production] GO:0002218[activation of innate immune response] GO:0002376[immune system process] GO:0003677[DNA binding] GO:0003690[double-stranded DNA binding] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006914[autophagy] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0008134[transcription factor binding] GO:0010506[regulation of autophagy] GO:0016020[membrane] GO:0016607[nuclear speck] GO:0030099[myeloid cell differentiation] GO:0030224[monocyte differentiation] GO:0032731[positive regulation of interleukin-1 beta production] GO:0035458[cellular response to interferon-beta] GO:0040029[epigenetic regulation of gene expression] GO:0042149[cellular response to glucose starvation] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0043392[negative regulation of DNA binding] GO:0045071[negative regulation of viral genome replication] GO:0045087[innate immune response] GO:0045824[negative regulation of innate immune response] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0051607[defense response to virus] GO:0071479[cellular response to ionizing radiation] GO:0072332[intrinsic apoptotic signaling pathway by p53 class mediator] GO:0097202[activation of cysteine-type endopeptidase activity] GO:2000117[negative regulation of cysteine-type endopeptidase activity]
Q16666 [Direct mapping] Gamma-interferon-inducible protein 16
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001819[positive regulation of cytokine production] GO:0002218[activation of innate immune response] GO:0002376[immune system process] GO:0003677[DNA binding] GO:0003690[double-stranded DNA binding] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006914[autophagy] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0008134[transcription factor binding] GO:0010506[regulation of autophagy] GO:0016020[membrane] GO:0016607[nuclear speck] GO:0030099[myeloid cell differentiation] GO:0030224[monocyte differentiation] GO:0032731[positive regulation of interleukin-1 beta production] GO:0035458[cellular response to interferon-beta] GO:0040029[epigenetic regulation of gene expression] GO:0042149[cellular response to glucose starvation] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0043392[negative regulation of DNA binding] GO:0045071[negative regulation of viral genome replication] GO:0045087[innate immune response] GO:0045824[negative regulation of innate immune response] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0051607[defense response to virus] GO:0071479[cellular response to ionizing radiation] GO:0072332[intrinsic apoptotic signaling pathway by p53 class mediator] GO:0097202[activation of cysteine-type endopeptidase activity] GO:2000117[negative regulation of cysteine-type endopeptidase activity]
Q16666 [Direct mapping] Gamma-interferon-inducible protein 16
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001819[positive regulation of cytokine production] GO:0002218[activation of innate immune response] GO:0002376[immune system process] GO:0003677[DNA binding] GO:0003690[double-stranded DNA binding] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006914[autophagy] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0008134[transcription factor binding] GO:0010506[regulation of autophagy] GO:0016020[membrane] GO:0016607[nuclear speck] GO:0030099[myeloid cell differentiation] GO:0030224[monocyte differentiation] GO:0032731[positive regulation of interleukin-1 beta production] GO:0035458[cellular response to interferon-beta] GO:0040029[epigenetic regulation of gene expression] GO:0042149[cellular response to glucose starvation] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0043392[negative regulation of DNA binding] GO:0045071[negative regulation of viral genome replication] GO:0045087[innate immune response] GO:0045824[negative regulation of innate immune response] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0051607[defense response to virus] GO:0071479[cellular response to ionizing radiation] GO:0072332[intrinsic apoptotic signaling pathway by p53 class mediator] GO:0097202[activation of cysteine-type endopeptidase activity] GO:2000117[negative regulation of cysteine-type endopeptidase activity]
Q16666 [Direct mapping] Gamma-interferon-inducible protein 16
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001819[positive regulation of cytokine production] GO:0002218[activation of innate immune response] GO:0002376[immune system process] GO:0003677[DNA binding] GO:0003690[double-stranded DNA binding] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006914[autophagy] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0008134[transcription factor binding] GO:0010506[regulation of autophagy] GO:0016020[membrane] GO:0016607[nuclear speck] GO:0030099[myeloid cell differentiation] GO:0030224[monocyte differentiation] GO:0032731[positive regulation of interleukin-1 beta production] GO:0035458[cellular response to interferon-beta] GO:0040029[epigenetic regulation of gene expression] GO:0042149[cellular response to glucose starvation] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0043392[negative regulation of DNA binding] GO:0045071[negative regulation of viral genome replication] GO:0045087[innate immune response] GO:0045824[negative regulation of innate immune response] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0051607[defense response to virus] GO:0071479[cellular response to ionizing radiation] GO:0072332[intrinsic apoptotic signaling pathway by p53 class mediator] GO:0097202[activation of cysteine-type endopeptidase activity] GO:2000117[negative regulation of cysteine-type endopeptidase activity]
The Human Protein Atlas project is funded
