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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q25.31
Chromosome location (bp)
156673235 - 156706770
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins 1,2,3. Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR 4,5....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, NAD, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q7Z3E1 [Direct mapping] Protein mono-ADP-ribosyltransferase TIPARP
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0001570[vasculogenesis] GO:0001822[kidney development] GO:0003950[NAD+ ADP-ribosyltransferase activity] GO:0005634[nucleus] GO:0006807[nitrogen compound metabolic process] GO:0008209[androgen metabolic process] GO:0008210[estrogen metabolic process] GO:0008585[female gonad development] GO:0009791[post-embryonic development] GO:0010629[negative regulation of gene expression] GO:0016740[transferase activity] GO:0016757[glycosyltransferase activity] GO:0016779[nucleotidyltransferase activity] GO:0030097[hemopoiesis] GO:0045732[positive regulation of protein catabolic process] GO:0046872[metal ion binding] GO:0048008[platelet-derived growth factor receptor signaling pathway] GO:0048705[skeletal system morphogenesis] GO:0048745[smooth muscle tissue development] GO:0060021[roof of mouth development] GO:0060325[face morphogenesis] GO:0071407[cellular response to organic cyclic compound] GO:0140803[NAD+- protein-cysteine ADP-ribosyltransferase activity] GO:1990404[NAD+-protein ADP-ribosyltransferase activity]
Q7Z3E1 [Direct mapping] Protein mono-ADP-ribosyltransferase TIPARP
Show all
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0003950[NAD+ ADP-ribosyltransferase activity] GO:0005634[nucleus] GO:0010629[negative regulation of gene expression] GO:0016740[transferase activity] GO:0016757[glycosyltransferase activity] GO:0016779[nucleotidyltransferase activity] GO:0045732[positive regulation of protein catabolic process] GO:0046872[metal ion binding] GO:0071407[cellular response to organic cyclic compound] GO:0140803[NAD+- protein-cysteine ADP-ribosyltransferase activity] GO:1990404[NAD+-protein ADP-ribosyltransferase activity]
Q7Z3E1 [Direct mapping] Protein mono-ADP-ribosyltransferase TIPARP
Show all
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0003950[NAD+ ADP-ribosyltransferase activity] GO:0005634[nucleus] GO:0010629[negative regulation of gene expression] GO:0016740[transferase activity] GO:0016757[glycosyltransferase activity] GO:0016779[nucleotidyltransferase activity] GO:0045732[positive regulation of protein catabolic process] GO:0046872[metal ion binding] GO:0071407[cellular response to organic cyclic compound] GO:0140803[NAD+- protein-cysteine ADP-ribosyltransferase activity] GO:1990404[NAD+-protein ADP-ribosyltransferase activity]
Q7Z3E1 [Direct mapping] Protein mono-ADP-ribosyltransferase TIPARP
Show all
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0003950[NAD+ ADP-ribosyltransferase activity] GO:0005634[nucleus] GO:0010629[negative regulation of gene expression] GO:0016740[transferase activity] GO:0016757[glycosyltransferase activity] GO:0016779[nucleotidyltransferase activity] GO:0045732[positive regulation of protein catabolic process] GO:0046872[metal ion binding] GO:0071407[cellular response to organic cyclic compound] GO:0140803[NAD+- protein-cysteine ADP-ribosyltransferase activity] GO:1990404[NAD+-protein ADP-ribosyltransferase activity]
The Human Protein Atlas project is funded
