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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Metabolic proteins RNA polymerase related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q27.1
Chromosome location (bp)
184361710 - 184368596
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription
Gene summary (Entrez)i
Useful information about the gene from Entrez
The three eukaryotic RNA polymerases are complex multisubunit enzymes that play a central role in the transcription of nuclear genes. This gene encodes an essential and highly conserved subunit of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
C9JJJ9 [Direct mapping] DNA-directed RNA polymerases I, II, and III subunit RPABC3
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Metabolic proteins DeepTMHMM predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014)
P52434 [Direct mapping] DNA-directed RNA polymerases I, II, and III subunit RPABC3
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Metabolic proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RNA polymerase related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
P52434 [Direct mapping] DNA-directed RNA polymerases I, II, and III subunit RPABC3
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RNA polymerase related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
P52434 [Direct mapping] DNA-directed RNA polymerases I, II, and III subunit RPABC3
Show all
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RNA polymerase related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
P52434 [Direct mapping] DNA-directed RNA polymerases I, II, and III subunit RPABC3
Show all
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RNA polymerase related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
P52434 [Direct mapping] DNA-directed RNA polymerases I, II, and III subunit RPABC3
Show all
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RNA polymerase related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
C9JLU1 [Direct mapping] DNA-directed RNA polymerases I, II, and III subunit RPABC3
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014)
P52434 [Direct mapping] DNA-directed RNA polymerases I, II, and III subunit RPABC3
Show all
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RNA polymerase related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
