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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
p21.1
Chromosome location (bp)
53156009 - 53192717
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses 1,2. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis 3,4. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 5,6. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 7,8. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 9. Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways 10. May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA 11. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation 12. Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release 13. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin 14. The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment 15. Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis 16. Phosphorylates SMPD1 which induces SMPD1 secretion 17....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
The protein encoded by this gene is a member of the protein kinase C family of serine- and threonine-specific protein kinases. The encoded protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progression. Also, this protein can positively or negatively regulate apoptosis. Defects in this gene are a cause of autoimmune lymphoproliferative syndrome. [provided by RefSeq, Aug 2017]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q05655 [Direct mapping] Protein kinase C delta type Protein kinase C delta type regulatory subunit Protein kinase C delta type catalytic subunit
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A0A024R328 [Target identity:100%; Query identity:100%] Protein kinase C delta type
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004697[protein kinase C activity] GO:0004698[calcium-dependent protein kinase C activity] GO:0004699[calcium-independent protein kinase C activity] GO:0004713[protein tyrosine kinase activity] GO:0004715[non-membrane spanning protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005783[endoplasmic reticulum] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007165[signal transduction] GO:0008047[enzyme activator activity] GO:0008631[intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0010469[regulation of signaling receptor activity] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0016064[immunoglobulin mediated immune response] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016363[nuclear matrix] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0023021[termination of signal transduction] GO:0030837[negative regulation of actin filament polymerization] GO:0032079[positive regulation of endodeoxyribonuclease activity] GO:0032091[negative regulation of protein binding] GO:0032147[activation of protein kinase activity] GO:0032930[positive regulation of superoxide anion generation] GO:0032956[regulation of actin cytoskeleton organization] GO:0034351[negative regulation of glial cell apoptotic process] GO:0034644[cellular response to UV] GO:0035307[positive regulation of protein dephosphorylation] GO:0035556[intracellular signal transduction] GO:0035578[azurophil granule lumen] GO:0036019[endolysosome] GO:0038096[Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042100[B cell proliferation] GO:0042119[neutrophil activation] GO:0042307[positive regulation of protein import into nucleus] GO:0042742[defense response to bacterium] GO:0043407[negative regulation of MAP kinase activity] GO:0043488[regulation of mRNA stability] GO:0043560[insulin receptor substrate binding] GO:0043687[post-translational protein modification] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0050728[negative regulation of inflammatory response] GO:0050732[negative regulation of peptidyl-tyrosine phosphorylation] GO:0050821[protein stabilization] GO:0051490[negative regulation of filopodium assembly] GO:0060326[cell chemotaxis] GO:0070062[extracellular exosome] GO:0070301[cellular response to hydrogen peroxide] GO:0071447[cellular response to hydroperoxide] GO:0090331[negative regulation of platelet aggregation] GO:0090398[cellular senescence] GO:0106310[protein serine kinase activity] GO:1900163[positive regulation of phospholipid scramblase activity] GO:1904385[cellular response to angiotensin] GO:2000303[regulation of ceramide biosynthetic process] GO:2000304[positive regulation of ceramide biosynthetic process] GO:2000753[positive regulation of glucosylceramide catabolic process] GO:2000755[positive regulation of sphingomyelin catabolic process] GO:2001022[positive regulation of response to DNA damage stimulus] GO:2001235[positive regulation of apoptotic signaling pathway]
Q05655 [Direct mapping] Protein kinase C delta type Protein kinase C delta type regulatory subunit Protein kinase C delta type catalytic subunit
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A0A024R328 [Target identity:100%; Query identity:100%] Protein kinase C delta type
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004697[protein kinase C activity] GO:0004698[calcium-dependent protein kinase C activity] GO:0004699[calcium-independent protein kinase C activity] GO:0004713[protein tyrosine kinase activity] GO:0004715[non-membrane spanning protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005783[endoplasmic reticulum] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007165[signal transduction] GO:0008047[enzyme activator activity] GO:0008631[intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0010469[regulation of signaling receptor activity] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0023021[termination of signal transduction] GO:0030837[negative regulation of actin filament polymerization] GO:0032079[positive regulation of endodeoxyribonuclease activity] GO:0032091[negative regulation of protein binding] GO:0032147[activation of protein kinase activity] GO:0032930[positive regulation of superoxide anion generation] GO:0032956[regulation of actin cytoskeleton organization] GO:0034351[negative regulation of glial cell apoptotic process] GO:0034644[cellular response to UV] GO:0035307[positive regulation of protein dephosphorylation] GO:0035556[intracellular signal transduction] GO:0035578[azurophil granule lumen] GO:0036019[endolysosome] GO:0038096[Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042119[neutrophil activation] GO:0042307[positive regulation of protein import into nucleus] GO:0042742[defense response to bacterium] GO:0043407[negative regulation of MAP kinase activity] GO:0043488[regulation of mRNA stability] GO:0043560[insulin receptor substrate binding] GO:0043687[post-translational protein modification] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0050728[negative regulation of inflammatory response] GO:0050732[negative regulation of peptidyl-tyrosine phosphorylation] GO:0050821[protein stabilization] GO:0051490[negative regulation of filopodium assembly] GO:0060326[cell chemotaxis] GO:0070062[extracellular exosome] GO:0070301[cellular response to hydrogen peroxide] GO:0071447[cellular response to hydroperoxide] GO:0090331[negative regulation of platelet aggregation] GO:0090398[cellular senescence] GO:0106310[protein serine kinase activity] GO:1900163[positive regulation of phospholipid scramblase activity] GO:1904385[cellular response to angiotensin] GO:2000303[regulation of ceramide biosynthetic process] GO:2000304[positive regulation of ceramide biosynthetic process] GO:2000753[positive regulation of glucosylceramide catabolic process] GO:2000755[positive regulation of sphingomyelin catabolic process] GO:2001022[positive regulation of response to DNA damage stimulus]
C9K0E3 [Direct mapping] Protein kinase C delta type
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
A0A494C125 [Direct mapping] Protein kinase C delta type
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DeepTMHMM predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
C9JZU8 [Direct mapping] Protein kinase C delta type
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
C9J9P1 [Direct mapping] Protein kinase C delta type
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Q05655 [Direct mapping] Protein kinase C delta type Protein kinase C delta type regulatory subunit Protein kinase C delta type catalytic subunit
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A0A024R328 [Target identity:100%; Query identity:100%] Protein kinase C delta type
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004697[protein kinase C activity] GO:0004698[calcium-dependent protein kinase C activity] GO:0004699[calcium-independent protein kinase C activity] GO:0004713[protein tyrosine kinase activity] GO:0004715[non-membrane spanning protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005783[endoplasmic reticulum] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007165[signal transduction] GO:0008047[enzyme activator activity] GO:0008631[intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0010469[regulation of signaling receptor activity] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0023021[termination of signal transduction] GO:0030837[negative regulation of actin filament polymerization] GO:0032079[positive regulation of endodeoxyribonuclease activity] GO:0032091[negative regulation of protein binding] GO:0032147[activation of protein kinase activity] GO:0032930[positive regulation of superoxide anion generation] GO:0032956[regulation of actin cytoskeleton organization] GO:0034351[negative regulation of glial cell apoptotic process] GO:0034644[cellular response to UV] GO:0035307[positive regulation of protein dephosphorylation] GO:0035556[intracellular signal transduction] GO:0035578[azurophil granule lumen] GO:0036019[endolysosome] GO:0038096[Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042119[neutrophil activation] GO:0042307[positive regulation of protein import into nucleus] GO:0042742[defense response to bacterium] GO:0043407[negative regulation of MAP kinase activity] GO:0043488[regulation of mRNA stability] GO:0043560[insulin receptor substrate binding] GO:0043687[post-translational protein modification] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0050728[negative regulation of inflammatory response] GO:0050732[negative regulation of peptidyl-tyrosine phosphorylation] GO:0050821[protein stabilization] GO:0051490[negative regulation of filopodium assembly] GO:0060326[cell chemotaxis] GO:0070062[extracellular exosome] GO:0070301[cellular response to hydrogen peroxide] GO:0071447[cellular response to hydroperoxide] GO:0090331[negative regulation of platelet aggregation] GO:0090398[cellular senescence] GO:0106310[protein serine kinase activity] GO:1900163[positive regulation of phospholipid scramblase activity] GO:1904385[cellular response to angiotensin] GO:2000303[regulation of ceramide biosynthetic process] GO:2000304[positive regulation of ceramide biosynthetic process] GO:2000753[positive regulation of glucosylceramide catabolic process] GO:2000755[positive regulation of sphingomyelin catabolic process] GO:2001022[positive regulation of response to DNA damage stimulus]
A0A494C1T7 [Direct mapping] Protein kinase C delta type
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Q05655 [Direct mapping] Protein kinase C delta type Protein kinase C delta type regulatory subunit Protein kinase C delta type catalytic subunit
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A0A024R328 [Target identity:100%; Query identity:100%] Protein kinase C delta type
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004697[protein kinase C activity] GO:0004698[calcium-dependent protein kinase C activity] GO:0004699[calcium-independent protein kinase C activity] GO:0004713[protein tyrosine kinase activity] GO:0004715[non-membrane spanning protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005783[endoplasmic reticulum] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007165[signal transduction] GO:0008047[enzyme activator activity] GO:0008631[intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0010469[regulation of signaling receptor activity] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0023021[termination of signal transduction] GO:0030837[negative regulation of actin filament polymerization] GO:0032079[positive regulation of endodeoxyribonuclease activity] GO:0032091[negative regulation of protein binding] GO:0032147[activation of protein kinase activity] GO:0032930[positive regulation of superoxide anion generation] GO:0032956[regulation of actin cytoskeleton organization] GO:0034351[negative regulation of glial cell apoptotic process] GO:0034644[cellular response to UV] GO:0035307[positive regulation of protein dephosphorylation] GO:0035556[intracellular signal transduction] GO:0035578[azurophil granule lumen] GO:0036019[endolysosome] GO:0038096[Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042119[neutrophil activation] GO:0042307[positive regulation of protein import into nucleus] GO:0042742[defense response to bacterium] GO:0043407[negative regulation of MAP kinase activity] GO:0043488[regulation of mRNA stability] GO:0043560[insulin receptor substrate binding] GO:0043687[post-translational protein modification] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0050728[negative regulation of inflammatory response] GO:0050732[negative regulation of peptidyl-tyrosine phosphorylation] GO:0050821[protein stabilization] GO:0051490[negative regulation of filopodium assembly] GO:0060326[cell chemotaxis] GO:0070062[extracellular exosome] GO:0070301[cellular response to hydrogen peroxide] GO:0071447[cellular response to hydroperoxide] GO:0090331[negative regulation of platelet aggregation] GO:0090398[cellular senescence] GO:0106310[protein serine kinase activity] GO:1900163[positive regulation of phospholipid scramblase activity] GO:1904385[cellular response to angiotensin] GO:2000303[regulation of ceramide biosynthetic process] GO:2000304[positive regulation of ceramide biosynthetic process] GO:2000753[positive regulation of glucosylceramide catabolic process] GO:2000755[positive regulation of sphingomyelin catabolic process] GO:2001022[positive regulation of response to DNA damage stimulus]
Q05655 [Direct mapping] Protein kinase C delta type Protein kinase C delta type regulatory subunit Protein kinase C delta type catalytic subunit
Show all
A0A024R328 [Target identity:100%; Query identity:100%] Protein kinase C delta type
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004697[protein kinase C activity] GO:0004698[calcium-dependent protein kinase C activity] GO:0004699[calcium-independent protein kinase C activity] GO:0004713[protein tyrosine kinase activity] GO:0004715[non-membrane spanning protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005783[endoplasmic reticulum] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007165[signal transduction] GO:0008047[enzyme activator activity] GO:0008631[intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0010469[regulation of signaling receptor activity] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0023021[termination of signal transduction] GO:0030837[negative regulation of actin filament polymerization] GO:0032079[positive regulation of endodeoxyribonuclease activity] GO:0032091[negative regulation of protein binding] GO:0032147[activation of protein kinase activity] GO:0032930[positive regulation of superoxide anion generation] GO:0032956[regulation of actin cytoskeleton organization] GO:0034351[negative regulation of glial cell apoptotic process] GO:0034644[cellular response to UV] GO:0035307[positive regulation of protein dephosphorylation] GO:0035556[intracellular signal transduction] GO:0035578[azurophil granule lumen] GO:0036019[endolysosome] GO:0038096[Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042119[neutrophil activation] GO:0042307[positive regulation of protein import into nucleus] GO:0042742[defense response to bacterium] GO:0043407[negative regulation of MAP kinase activity] GO:0043488[regulation of mRNA stability] GO:0043560[insulin receptor substrate binding] GO:0043687[post-translational protein modification] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0050728[negative regulation of inflammatory response] GO:0050732[negative regulation of peptidyl-tyrosine phosphorylation] GO:0050821[protein stabilization] GO:0051490[negative regulation of filopodium assembly] GO:0060326[cell chemotaxis] GO:0070062[extracellular exosome] GO:0070301[cellular response to hydrogen peroxide] GO:0071447[cellular response to hydroperoxide] GO:0090331[negative regulation of platelet aggregation] GO:0090398[cellular senescence] GO:0106310[protein serine kinase activity] GO:1900163[positive regulation of phospholipid scramblase activity] GO:1904385[cellular response to angiotensin] GO:2000303[regulation of ceramide biosynthetic process] GO:2000304[positive regulation of ceramide biosynthetic process] GO:2000753[positive regulation of glucosylceramide catabolic process] GO:2000755[positive regulation of sphingomyelin catabolic process] GO:2001022[positive regulation of response to DNA damage stimulus]
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