Expression of S100P in urothelial cancer

BLADDER UROTHELIAL CARCINOMA (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

S100P is not prognostic in Bladder Urothelial Carcinoma (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 334.77

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average pTPM

2315.6

Number of samples

169

Samples

Sample	Description	pTPM
TCGA-FD-A6TI-01A	73 years, male, white, stage:Stage IV, dead, 294 days	18529.2
TCGA-BT-A3PH-01A	76 years, male, white, stage:Stage IV, dead, 142 days	14442.7
TCGA-CU-A5W6-01A	70 years, male, white, stage:Stage III, dead, 56 days	11177.4
TCGA-G2-A2EO-01A	69 years, male, white, stage:Stage III, dead, 1804 days	10630.0
TCGA-XF-AAN2-01A	73 years, male, white, stage:Stage II, dead, 1869 days	9740.9
TCGA-FJ-A3Z9-01A	72 years, male, white, stage:'--, dead, 385 days	9072.0
TCGA-XF-A9SV-01A	82 years, male, white, stage:Stage IV, dead, 388 days	8536.4
TCGA-GU-A42R-01A	68 years, male, white, stage:Stage IV, dead, 577 days	7913.2
TCGA-XF-A8HH-01A	61 years, female, white, stage:Stage IV, dead, 57 days	7447.3
TCGA-XF-A9SZ-01A	79 years, male, white, stage:Stage IV, dead, 859 days	6885.6
TCGA-4Z-AA7S-01A	66 years, male, black or african american, stage:Stage III, dead, 1064 days	6484.5
TCGA-ZF-A9R3-01A	53 years, female, white, stage:Stage II, dead, 949 days	6275.2
TCGA-GU-AATO-01A	75 years, male, white, stage:Stage IV, dead, 324 days	6001.9
TCGA-ZF-AA5N-01A	62 years, female, white, stage:Stage IV, dead, 168 days	5642.0
TCGA-UY-A78M-01A	81 years, female, asian, stage:Stage IV, dead, 690 days	5526.3
TCGA-CF-A9FL-01A	85 years, male, asian, stage:Stage III, dead, 565 days	5481.7
TCGA-ZF-AA4U-01A	70 years, male, white, stage:Stage III, dead, 262 days	5443.4
TCGA-FJ-A3ZE-01A	65 years, male, white, stage:Stage IV, dead, 324 days	5332.4
TCGA-XF-A8HI-01A	57 years, female, white, stage:Stage IV, dead, 544 days	5180.9
TCGA-2F-A9KO-01A	63 years, male, white, stage:Stage IV, dead, 734 days	5118.3
TCGA-2F-A9KR-01A	59 years, female, stage:Stage III, dead, 3183 days	5056.8
TCGA-CU-A0YR-01A	83 years, male, white, stage:Stage IV, dead, 460 days	4972.0
TCGA-BT-A20T-01A	63 years, male, white, stage:Stage IV, dead, 453 days	4875.6
TCGA-XF-AAMZ-01A	81 years, female, white, stage:Stage IV, dead, 1348 days	4832.9
TCGA-5N-A9KI-01A	76 years, female, white, stage:Stage III, dead, 76 days	4570.4
TCGA-G2-A3IE-01A	51 years, male, white, stage:Stage II, dead, 612 days	4277.6
TCGA-CU-A0YO-01A	84 years, male, white, stage:Stage IV, dead, 149 days	4213.7
TCGA-HQ-A5ND-01A	78 years, male, stage:Stage IV, dead, 274 days	4082.1
TCGA-FD-A3SL-01A	60 years, male, white, stage:Stage IV, dead, 712 days	4031.7
TCGA-FD-A5C0-01A	61 years, male, white, stage:Stage IV, dead, 550 days	4017.4
TCGA-E7-A97P-01A	73 years, male, asian, stage:Stage II, dead, 437 days	3873.8
TCGA-5N-A9KM-01A	73 years, female, white, stage:Stage III, dead, 530 days	3676.9
TCGA-UY-A78N-01A	80 years, male, white, stage:Stage IV, dead, 2641 days	3593.3
TCGA-FD-A3SM-01A	70 years, male, white, stage:Stage IV, dead, 547 days	3593.0
TCGA-HQ-A5NE-01A	57 years, male, stage:Stage III, dead, 370 days	3592.7
TCGA-BT-A20P-01A	81 years, female, white, stage:Stage III, dead, 544 days	3466.9
TCGA-2F-A9KP-01A	66 years, male, white, stage:Stage IV, dead, 364 days	3427.7
TCGA-DK-A1A5-01A	79 years, male, white, stage:Stage II, dead, 65 days	3360.8
TCGA-CF-A47T-01A	58 years, female, asian, stage:Stage II, dead, 385 days	3342.2
TCGA-ZF-AA56-01A	79 years, female, white, stage:Stage III, dead, 259 days	3338.1
TCGA-XF-A8HG-01A	69 years, male, white, stage:Stage III, dead, 467 days	3317.6
TCGA-G2-A2ES-01A	85 years, male, white, stage:Stage II, dead, 1004 days	3287.3
TCGA-DK-A3IL-01A	79 years, female, white, stage:Stage IV, dead, 413 days	3224.7
TCGA-GV-A3QH-01A	67 years, male, white, stage:Stage II, dead, 258 days	3204.8
TCGA-ZF-A9R0-01A	82 years, male, white, stage:Stage III, dead, 680 days	3200.6
TCGA-FD-A6TH-01A	63 years, male, white, stage:Stage IV, dead, 131 days	3121.0
TCGA-XF-A8HF-01A	80 years, male, white, stage:Stage III, dead, 2954 days	3072.0
TCGA-GC-A3BM-01A	70 years, male, white, stage:Stage II, dead, 651 days	3067.0
TCGA-E7-A4XJ-01A	66 years, male, asian, stage:Stage II, dead, 68 days	3062.5
TCGA-XF-A9SU-01A	74 years, female, white, stage:Stage IV, dead, 182 days	3060.8
TCGA-GU-A767-01A	81 years, male, white, stage:Stage IV, dead, 144 days	3011.8
TCGA-XF-AAML-01A	75 years, male, white, stage:Stage II, dead, 232 days	2993.7
TCGA-FD-A5BV-01A	47 years, female, white, stage:Stage III, dead, 163 days	2953.7
TCGA-BT-A20U-01A	70 years, female, white, stage:Stage III, dead, 455 days	2913.6
TCGA-FD-A6TD-01A	77 years, male, white, stage:Stage III, dead, 386 days	2781.7
TCGA-4Z-AA7N-01A	65 years, male, white, stage:Stage III, dead, 1367 days	2759.1
TCGA-GV-A3QF-01A	79 years, male, white, stage:Stage IV, dead, 617 days	2749.8
TCGA-UY-A78K-01A	60 years, male, white, stage:Stage IV, dead, 536 days	2697.8
TCGA-DK-A3IK-01A	87 years, male, white, stage:Stage IV, dead, 146 days	2679.8
TCGA-4Z-AA81-01A	80 years, male, white, stage:Stage II, dead, 1270 days	2606.3
TCGA-XF-AAN1-01A	75 years, female, stage:Stage III, dead, 941 days	2590.9
TCGA-FD-A5BZ-01A	77 years, female, white, stage:Stage IV, dead, 835 days	2552.1
TCGA-XF-A9SH-01A	65 years, female, asian, stage:Stage II, dead, 1971 days	2385.5
TCGA-E7-A541-01A	66 years, male, white, stage:Stage II, dead, 778 days	2328.8
TCGA-BT-A2LB-01A	73 years, female, white, stage:Stage III, dead, 492 days	2278.2
TCGA-FD-A62O-01A	74 years, male, white, stage:Stage IV, dead, 216 days	2273.5
TCGA-XF-A9SL-01A	69 years, male, white, stage:Stage IV, dead, 2020 days	2269.4
TCGA-DK-A1A3-01A	60 years, male, white, stage:Stage IV, dead, 665 days	2235.2
TCGA-GV-A3JV-01A	66 years, male, white, stage:Stage IV, dead, 434 days	2170.9
TCGA-E7-A3X6-01A	70 years, male, white, stage:Stage II, dead, 904 days	2138.2
TCGA-DK-A2HX-01A	80 years, female, white, stage:Stage IV, dead, 1420 days	2117.1
TCGA-FD-A3SO-01A	68 years, male, white, stage:Stage IV, dead, 168 days	2098.0
TCGA-XF-A8HC-01A	79 years, male, asian, stage:Stage IV, dead, 200 days	2057.1
TCGA-XF-A9SJ-01A	83 years, male, white, stage:Stage IV, dead, 98 days	1979.4
TCGA-BT-A2LD-01A	78 years, female, white, stage:Stage IV, dead, 623 days	1957.9
TCGA-XF-A9SP-01A	59 years, male, white, stage:Stage III, dead, 454 days	1909.0
TCGA-BT-A20Q-01A	73 years, male, white, stage:Stage IV, dead, 593 days	1885.6
TCGA-CU-A72E-01A	76 years, male, white, stage:Stage IV, dead, 413 days	1861.4
TCGA-BT-A20N-01A	72 years, male, stage:Stage III, dead, 795 days	1803.9
TCGA-FD-A3SR-01A	68 years, male, white, stage:Stage IV, dead, 602 days	1791.2
TCGA-4Z-AA80-01A	73 years, male, white, stage:Stage II, dead, 19 days	1751.9
TCGA-FD-A6TG-01A	73 years, male, white, stage:Stage IV, dead, 93 days	1728.7
TCGA-XF-AAMX-01A	87 years, female, black or african american, stage:Stage III, dead, 206 days	1638.2
TCGA-BT-A20W-01A	71 years, male, white, stage:Stage II, dead, 254 days	1613.7
TCGA-K4-A5RI-01A	67 years, female, white, stage:Stage III, dead, 356 days	1596.7
TCGA-ZF-A9RE-01A	78 years, female, white, stage:Stage II, dead, 106 days	1571.8
TCGA-GC-A3I6-01A	45 years, male, white, stage:Stage III, dead, 630 days	1545.7
TCGA-G2-A2EC-01A	58 years, female, black or african american, stage:Stage II, dead, 696 days	1444.2
TCGA-FD-A3SJ-01A	59 years, male, white, stage:Stage IV, dead, 739 days	1402.4
TCGA-XF-A9SW-01A	85 years, male, white, stage:Stage IV, dead, 362 days	1391.1
TCGA-GV-A40E-01A	75 years, male, white, stage:Stage II, dead, 261 days	1369.8
TCGA-FD-A3SQ-01A	62 years, male, white, stage:Stage IV, dead, 1423 days	1357.2
TCGA-ZF-AA52-01A	70 years, male, white, stage:Stage III, dead, 1077 days	1290.7
TCGA-XF-AAMH-01A	80 years, male, white, stage:Stage IV, dead, 344 days	1287.6
TCGA-SY-A9G0-01A	82 years, male, white, stage:Stage IV, dead, 1008 days	1280.0
TCGA-DK-AA6L-01A	48 years, male, white, stage:Stage IV, dead, 1163 days	1276.7
TCGA-FD-A62P-01A	76 years, male, white, stage:Stage II, dead, 191 days	1126.3
TCGA-BL-A13J-01A	65 years, male, white, stage:Stage IV, dead, 81 days	1122.4
TCGA-DK-A3IN-01A	72 years, male, white, stage:Stage III, dead, 250 days	1109.5
TCGA-GU-AATQ-01A	68 years, male, white, stage:Stage III, dead, 213 days	1104.9
TCGA-FD-A6TF-01A	80 years, female, white, stage:Stage IV, dead, 69 days	1080.2
TCGA-XF-AAN0-01A	68 years, male, white, stage:Stage IV, dead, 1718 days	1043.9
TCGA-DK-AA75-01A	82 years, male, white, stage:Stage III, dead, 340 days	1034.7
TCGA-GU-A42P-01A	72 years, male, white, stage:Stage IV, dead, 332 days	996.7
TCGA-2F-A9KW-01A	67 years, female, white, stage:Stage III, dead, 254 days	935.1
TCGA-S5-A6DX-01A	83 years, male, white, stage:Stage IV, dead, 56 days	918.4
TCGA-CU-A0YN-01A	60 years, male, white, stage:Stage III, dead, 393 days	738.1
TCGA-DK-A3IU-01A	58 years, male, white, stage:Stage II, dead, 706 days	724.6
TCGA-XF-A9SK-01A	65 years, male, white, stage:Stage IV, dead, 486 days	656.1
TCGA-G2-A3IB-01A	66 years, male, black or african american, stage:Stage II, dead, 220 days	612.1
TCGA-XF-A9T8-01A	64 years, male, white, stage:Stage III, dead, 418 days	577.8
TCGA-XF-AAMJ-01A	70 years, male, asian, stage:Stage III, dead, 1670 days	558.7
TCGA-FD-A3SS-01A	66 years, male, white, stage:Stage IV, dead, 391 days	554.7
TCGA-XF-AAMW-01A	79 years, female, white, stage:Stage IV, dead, 253 days	477.0
TCGA-ZF-AA4R-01A	67 years, male, white, stage:Stage IV, dead, 1036 days	465.6
TCGA-XF-A9T2-01A	54 years, male, white, stage:Stage III, dead, 575 days	434.1
TCGA-XF-AAMT-01A	75 years, female, white, stage:Stage IV, dead, 90 days	404.9
TCGA-FD-A43Y-01A	65 years, male, white, stage:Stage III, dead, 474 days	401.6
TCGA-4Z-AA7R-01A	73 years, male, black or african american, stage:Stage IV, dead, 522 days	400.2
TCGA-BT-A0YX-01A	70 years, female, white, stage:Stage III, dead, 400 days	384.6
TCGA-FD-A3B5-01A	86 years, male, black or african american, stage:Stage IV, dead, 272 days	375.9
TCGA-XF-AAME-01A	64 years, female, white, stage:Stage II, dead, 2828 days	375.3
TCGA-ZF-A9RD-01A	75 years, female, white, stage:Stage IV, dead, 408 days	359.4
TCGA-ZF-A9R9-01A	58 years, male, white, stage:Stage IV, dead, 864 days	356.4
TCGA-E5-A4TZ-01A	64 years, male, white, stage:Stage IV, dead, 467 days	344.7
TCGA-XF-A9SX-01A	63 years, female, white, stage:Stage IV, dead, 719 days	344.5
TCGA-4Z-AA7Q-01A	79 years, male, white, stage:Stage III, dead, 510 days	341.1
TCGA-BT-A0S7-01A	75 years, male, white, stage:Stage III, dead, 200 days	328.4
TCGA-BT-A20V-01A	59 years, female, black or african american, stage:Stage IV, dead, 154 days	292.6
TCGA-FD-A3B3-01A	74 years, female, white, stage:Stage III, dead, 974 days	213.3
TCGA-FD-A5BX-01A	82 years, male, white, stage:Stage IV, dead, 173 days	209.1
TCGA-DK-A1AB-01A	74 years, female, white, stage:Stage IV, dead, 508 days	192.7
TCGA-DK-A3IQ-01A	74 years, male, white, stage:Stage III, dead, 539 days	173.0
TCGA-C4-A0F7-01A	77 years, male, stage:Stage IV, dead, 62 days	172.6
TCGA-ZF-AA4T-01A	65 years, male, white, stage:Stage IV, dead, 599 days	170.3
TCGA-BT-A20J-01A	75 years, male, white, stage:Stage II, dead, 579 days	168.8
TCGA-XF-A9ST-01A	68 years, male, white, stage:Stage III, dead, 128 days	165.2
TCGA-BT-A20X-01A	56 years, male, white, stage:Stage IV, dead, 251 days	162.8
TCGA-FD-A5BT-01A	84 years, male, white, stage:Stage III, dead, 328 days	162.2
TCGA-DK-A3X2-01A	85 years, male, white, stage:Stage IV, dead, 547 days	159.2
TCGA-DK-AA6W-01A	78 years, male, white, stage:Stage II, dead, 415 days	158.9
TCGA-BT-A3PK-01A	80 years, male, white, stage:Stage II, dead, 303 days	116.1
TCGA-DK-A3IM-01A	76 years, male, white, stage:Stage III, dead, 248 days	112.6
TCGA-FD-A62S-01A	60 years, female, black or african american, stage:Stage III, dead, 406 days	110.8
TCGA-FJ-A871-01A	49 years, male, white, stage:Stage III, dead, 272 days	110.7
TCGA-FD-A3N5-01A	69 years, male, black or african american, stage:Stage II, dead, 685 days	100.0
TCGA-DK-A2I2-01A	63 years, female, white, stage:Stage IV, dead, 237 days	92.8
TCGA-C4-A0EZ-01A	69 years, female, stage:Stage IV, dead, 273 days	68.2
TCGA-K4-A4AC-01A	83 years, male, white, stage:Stage II, dead, 278 days	65.4
TCGA-4Z-AA86-01A	66 years, male, black or african american, stage:Stage IV, dead, 311 days	65.1
TCGA-FD-A3B4-01A	55 years, female, black or african american, stage:Stage III, dead, 510 days	64.5
TCGA-FD-A3B7-01A	66 years, male, black or african american, stage:Stage III, dead, 122 days	59.6
TCGA-YC-A9TC-01A	71 years, male, white, stage:Stage IV, dead, 20 days	54.5
TCGA-XF-AAN8-01A	74 years, female, white, stage:Stage III, dead, 118 days	54.5
TCGA-DK-AA6Q-01A	61 years, female, white, stage:Stage IV, dead, 413 days	41.8
TCGA-ZF-AA4N-01A	74 years, male, white, stage:Stage II, dead, 88 days	27.1
TCGA-GU-A42Q-01A	67 years, male, white, stage:Stage III, dead, 344 days	25.4
TCGA-ZF-A9RN-01A	67 years, female, white, stage:Stage III, dead, 615 days	12.0
TCGA-FD-A3B6-01A	75 years, male, white, stage:Stage II, dead, 1005 days	10.3
TCGA-4Z-AA82-01A	59 years, male, black or african american, stage:Stage IV, dead, 1556 days	8.9
TCGA-ZF-AA54-01A	71 years, male, white, stage:Stage III, dead, 590 days	3.9
TCGA-G2-A2EL-01A	77 years, male, white, stage:Stage II, dead, 819 days	3.1
TCGA-XF-AAN7-01A	60 years, male, white, stage:Stage IV, dead, 565 days	1.3
TCGA-BL-A3JM-01A	62 years, male, white, stage:Stage III, dead, 205 days	0.7
TCGA-GU-A762-01A	87 years, male, white, stage:Stage IV, dead, 232 days	0.2
TCGA-XF-AAN4-01A	77 years, female, white, stage:Stage III, dead, 823 days	0.0
TCGA-BL-A13I-01A	57 years, female, white, stage:Stage III, dead, 223 days	0.0
TCGA-G2-AA3C-01A	66 years, male, white, stage:Stage IV, dead, 211 days	0.0
TCGA-BT-A20O-01A	75 years, male, white, stage:Stage III, dead, 370 days	0.0
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UROTHELIAL CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.	Antibody HPA019502
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Urothelial carcinoma, Low grade
Urothelial carcinoma, High grade
Urothelial carcinoma, Low grade Urothelial carcinoma, High grade