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STARD4
HPA
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  • STARD4
PROTEIN SUMMARY GENE INFORMATION RNA DATA ANTIBODY DATA
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

STARD4
Synonyms
Gene descriptioni

Full gene name according to HGNC.

StAR related lipid transfer domain containing 4
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Metabolic proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 5
Cytoband q22.1
Chromosome location (bp) 111496033 - 111512590
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

5
Ensembl ENSG00000164211 (version 109)
Entrez gene 134429
HGNC HGNC:18058
UniProt Q96DR4 (UniProt - Evidence at protein level)
neXtProt NX_Q96DR4
GeneCards STARD4
Antibodypedia STARD4 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i

Useful information about the protein provided by UniProt.

Involved in the intracellular transport of cholesterol. Binds cholesterol or other sterols.... show less
Biological process (UniProt)i

Keywords assigned by UniProt to proteins because they are involved in a particular biological process.

Lipid transport, Transport
Ligand (UniProt)i

Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.

Lipid-binding
Gene summary (Entrez)i

Useful information about the gene from Entrez

Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002).[supplied by OMIM, Mar 2008]... show less
PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
STARD4-201
ENSP00000296632
ENST00000296632
Q96DR4
[Direct mapping] StAR-related lipid transfer protein 4
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0010879 [cholesterol transport involved in cholesterol storage]
GO:0015485 [cholesterol binding]
GO:0031410 [cytoplasmic vesicle]
GO:0032367 [intracellular cholesterol transport]
GO:0070508 [cholesterol import]
GO:0070859 [positive regulation of bile acid biosynthetic process]
GO:0090205 [positive regulation of cholesterol metabolic process]
GO:0120009 [intermembrane lipid transfer]
GO:0120020 [cholesterol transfer activity]
Show all
205 aa
23.5 kDa
No 0
STARD4-203
ENSP00000427639
ENST00000502322
Q96DR4
[Direct mapping] StAR-related lipid transfer protein 4
Show all
Metabolic proteins
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0010879 [cholesterol transport involved in cholesterol storage]
GO:0015485 [cholesterol binding]
GO:0031410 [cytoplasmic vesicle]
GO:0032367 [intracellular cholesterol transport]
GO:0070508 [cholesterol import]
GO:0070859 [positive regulation of bile acid biosynthetic process]
GO:0090205 [positive regulation of cholesterol metabolic process]
GO:0120009 [intermembrane lipid transfer]
GO:0120020 [cholesterol transfer activity]
Show all
159 aa
18.5 kDa
No 0
STARD4-205
ENSP00000427478
ENST00000505803
Q96DR4
[Direct mapping] StAR-related lipid transfer protein 4
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0010879 [cholesterol transport involved in cholesterol storage]
GO:0015485 [cholesterol binding]
GO:0031410 [cytoplasmic vesicle]
GO:0032367 [intracellular cholesterol transport]
GO:0070508 [cholesterol import]
GO:0070859 [positive regulation of bile acid biosynthetic process]
GO:0090205 [positive regulation of cholesterol metabolic process]
GO:0120009 [intermembrane lipid transfer]
GO:0120020 [cholesterol transfer activity]
Show all
205 aa
23.5 kDa
No 0
STARD4-207
ENSP00000425308
ENST00000509887
D6RDM5
[Direct mapping] START domain containing 4, sterol regulated, isoform CRA_e; StAR-related lipid transfer protein 4
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0015485 [cholesterol binding]
GO:0032367 [intracellular cholesterol transport]
Show all
55 aa
6.4 kDa
No 0
STARD4-212
ENSP00000426148
ENST00000512160
D6RDM5
[Direct mapping] START domain containing 4, sterol regulated, isoform CRA_e; StAR-related lipid transfer protein 4
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0015485 [cholesterol binding]
GO:0032367 [intracellular cholesterol transport]
Show all
55 aa
6.4 kDa
No 0

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