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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes Metabolic proteins Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
q36.1
Chromosome location (bp)
150991017 - 151014588
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway 1. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Calmodulin-binding, Oxidoreductase
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Musculoskeletal diseases Skeletal diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139[Golgi membrane] GO:0001525[angiogenesis] GO:0001542[ovulation from ovarian follicle] GO:0001701[in utero embryonic development] GO:0001974[blood vessel remodeling] GO:0002028[regulation of sodium ion transport] GO:0003057[regulation of the force of heart contraction by chemical signal] GO:0003100[regulation of systemic arterial blood pressure by endothelin] GO:0003180[aortic valve morphogenesis] GO:0003184[pulmonary valve morphogenesis] GO:0003203[endocardial cushion morphogenesis] GO:0003785[actin monomer binding] GO:0004517[nitric-oxide synthase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0005901[caveola] GO:0006527[arginine catabolic process] GO:0006809[nitric oxide biosynthetic process] GO:0006813[potassium ion transport] GO:0006816[calcium ion transport] GO:0007005[mitochondrion organization] GO:0007263[nitric oxide mediated signal transduction] GO:0008217[regulation of blood pressure] GO:0008285[negative regulation of cell population proliferation] GO:0009408[response to heat] GO:0009725[response to hormone] GO:0010181[FMN binding] GO:0010544[negative regulation of platelet activation] GO:0010628[positive regulation of gene expression] GO:0012506[vesicle membrane] GO:0014740[negative regulation of muscle hyperplasia] GO:0014806[smooth muscle hyperplasia] GO:0016020[membrane] GO:0016491[oxidoreductase activity] GO:0019430[removal of superoxide radicals] GO:0020037[heme binding] GO:0030324[lung development] GO:0030666[endocytic vesicle membrane] GO:0031284[positive regulation of guanylate cyclase activity] GO:0031644[regulation of nervous system process] GO:0031663[lipopolysaccharide-mediated signaling pathway] GO:0032496[response to lipopolysaccharide] GO:0034405[response to fluid shear stress] GO:0034617[tetrahydrobiopterin binding] GO:0034618[arginine binding] GO:0042311[vasodilation] GO:0043267[negative regulation of potassium ion transport] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0043542[endothelial cell migration] GO:0044249[cellular biosynthetic process] GO:0045454[cell redox homeostasis] GO:0045747[positive regulation of Notch signaling pathway] GO:0045766[positive regulation of angiogenesis] GO:0045776[negative regulation of blood pressure] GO:0046870[cadmium ion binding] GO:0046872[metal ion binding] GO:0048662[negative regulation of smooth muscle cell proliferation] GO:0048873[homeostasis of number of cells within a tissue] GO:0050660[flavin adenine dinucleotide binding] GO:0050661[NADP binding] GO:0051346[negative regulation of hydrolase activity] GO:0051649[establishment of localization in cell] GO:0051926[negative regulation of calcium ion transport] GO:0060412[ventricular septum morphogenesis] GO:0070168[negative regulation of biomineral tissue development] GO:0097110[scaffold protein binding] GO:0097746[blood vessel diameter maintenance] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
Metabolic proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Skeletal diseases Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Musculoskeletal diseases Skeletal diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139[Golgi membrane] GO:0001974[blood vessel remodeling] GO:0003100[regulation of systemic arterial blood pressure by endothelin] GO:0003180[aortic valve morphogenesis] GO:0003184[pulmonary valve morphogenesis] GO:0003203[endocardial cushion morphogenesis] GO:0003785[actin monomer binding] GO:0004517[nitric-oxide synthase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0005901[caveola] GO:0006527[arginine catabolic process] GO:0006809[nitric oxide biosynthetic process] GO:0007005[mitochondrion organization] GO:0007263[nitric oxide mediated signal transduction] GO:0008217[regulation of blood pressure] GO:0008285[negative regulation of cell population proliferation] GO:0009408[response to heat] GO:0009725[response to hormone] GO:0010181[FMN binding] GO:0010544[negative regulation of platelet activation] GO:0010628[positive regulation of gene expression] GO:0012506[vesicle membrane] GO:0014740[negative regulation of muscle hyperplasia] GO:0014806[smooth muscle hyperplasia] GO:0016020[membrane] GO:0016491[oxidoreductase activity] GO:0019430[removal of superoxide radicals] GO:0020037[heme binding] GO:0030666[endocytic vesicle membrane] GO:0031284[positive regulation of guanylate cyclase activity] GO:0031644[regulation of nervous system process] GO:0032496[response to lipopolysaccharide] GO:0034405[response to fluid shear stress] GO:0034617[tetrahydrobiopterin binding] GO:0034618[arginine binding] GO:0042311[vasodilation] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0043542[endothelial cell migration] GO:0044249[cellular biosynthetic process] GO:0045454[cell redox homeostasis] GO:0045747[positive regulation of Notch signaling pathway] GO:0045766[positive regulation of angiogenesis] GO:0045776[negative regulation of blood pressure] GO:0046870[cadmium ion binding] GO:0046872[metal ion binding] GO:0048873[homeostasis of number of cells within a tissue] GO:0050660[flavin adenine dinucleotide binding] GO:0050661[NADP binding] GO:0070168[negative regulation of biomineral tissue development] GO:0097746[blood vessel diameter maintenance] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Skeletal diseases Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Musculoskeletal diseases Skeletal diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139[Golgi membrane] GO:0001974[blood vessel remodeling] GO:0003100[regulation of systemic arterial blood pressure by endothelin] GO:0003180[aortic valve morphogenesis] GO:0003184[pulmonary valve morphogenesis] GO:0003203[endocardial cushion morphogenesis] GO:0003785[actin monomer binding] GO:0004517[nitric-oxide synthase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0005901[caveola] GO:0006527[arginine catabolic process] GO:0006809[nitric oxide biosynthetic process] GO:0007005[mitochondrion organization] GO:0007263[nitric oxide mediated signal transduction] GO:0008217[regulation of blood pressure] GO:0008285[negative regulation of cell population proliferation] GO:0009408[response to heat] GO:0009725[response to hormone] GO:0010181[FMN binding] GO:0010544[negative regulation of platelet activation] GO:0010628[positive regulation of gene expression] GO:0012506[vesicle membrane] GO:0014740[negative regulation of muscle hyperplasia] GO:0014806[smooth muscle hyperplasia] GO:0016020[membrane] GO:0016491[oxidoreductase activity] GO:0019430[removal of superoxide radicals] GO:0020037[heme binding] GO:0030666[endocytic vesicle membrane] GO:0031284[positive regulation of guanylate cyclase activity] GO:0031644[regulation of nervous system process] GO:0032496[response to lipopolysaccharide] GO:0034405[response to fluid shear stress] GO:0034617[tetrahydrobiopterin binding] GO:0034618[arginine binding] GO:0042311[vasodilation] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0043542[endothelial cell migration] GO:0044249[cellular biosynthetic process] GO:0045454[cell redox homeostasis] GO:0045747[positive regulation of Notch signaling pathway] GO:0045766[positive regulation of angiogenesis] GO:0045776[negative regulation of blood pressure] GO:0046870[cadmium ion binding] GO:0046872[metal ion binding] GO:0048873[homeostasis of number of cells within a tissue] GO:0050660[flavin adenine dinucleotide binding] GO:0050661[NADP binding] GO:0070168[negative regulation of biomineral tissue development] GO:0097746[blood vessel diameter maintenance] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
The Human Protein Atlas project is funded
