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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
q22.3
Chromosome location (bp)
100916523 - 100953388
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways 1,2,3,4,5,6,7. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif 8. Binding generally results in the modulation of the activity of the binding partner 9. Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB 10. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation 11. In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity)....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
D0PNI1 [Target identity:100%; Query identity:100%] Epididymis luminal protein 4; Epididymis secretory protein Li 3; Epididymis secretory protein Li 93; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide, isoform CRA_a
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Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
D0PNI1 [Target identity:100%; Query identity:100%] Epididymis luminal protein 4; Epididymis secretory protein Li 3; Epididymis secretory protein Li 93; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide, isoform CRA_a
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
D0PNI1 [Target identity:100%; Query identity:100%] Epididymis luminal protein 4; Epididymis secretory protein Li 3; Epididymis secretory protein Li 93; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide, isoform CRA_a
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
D0PNI1 [Target identity:100%; Query identity:100%] Epididymis luminal protein 4; Epididymis secretory protein Li 3; Epididymis secretory protein Li 93; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide, isoform CRA_a
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
D0PNI1 [Target identity:100%; Query identity:100%] Epididymis luminal protein 4; Epididymis secretory protein Li 3; Epididymis secretory protein Li 93; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide, isoform CRA_a
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
D0PNI1 [Target identity:100%; Query identity:100%] Epididymis luminal protein 4; Epididymis secretory protein Li 3; Epididymis secretory protein Li 93; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide, isoform CRA_a
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
D0PNI1 [Target identity:100%; Query identity:100%] Epididymis luminal protein 4; Epididymis secretory protein Li 3; Epididymis secretory protein Li 93; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide, isoform CRA_a
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
D0PNI1 [Target identity:100%; Query identity:100%] Epididymis luminal protein 4; Epididymis secretory protein Li 3; Epididymis secretory protein Li 93; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide, isoform CRA_a
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
