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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
p13.3
Chromosome location (bp)
34179005 - 34252523
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Component of the ESCRT-I complex, a regulator of vesicular trafficking process 1,2,3. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) 4,5. Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 6,7,8....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Protein transport, Transport
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9NZ09 [Direct mapping] Ubiquitin-associated protein 1
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A0A6G6AA68 [Target identity:100%; Query identity:100%] Ubiquitin associated protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Nervous system diseases Other nervous and sensory system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000813[ESCRT I complex] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0010008[endosome membrane] GO:0015031[protein transport] GO:0036258[multivesicular body assembly] GO:0043130[ubiquitin binding] GO:0043162[ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway] GO:0043231[intracellular membrane-bounded organelle] GO:0043328[protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway] GO:0090148[membrane fission]
Q9NZ09 [Direct mapping] Ubiquitin-associated protein 1
Show all
A0A6G6AA68 [Target identity:100%; Query identity:100%] Ubiquitin associated protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Nervous system diseases Other nervous and sensory system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000813[ESCRT I complex] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0010008[endosome membrane] GO:0015031[protein transport] GO:0036258[multivesicular body assembly] GO:0043130[ubiquitin binding] GO:0043162[ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway] GO:0043231[intracellular membrane-bounded organelle] GO:0043328[protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway] GO:0090148[membrane fission]
Q9NZ09 [Direct mapping] Ubiquitin-associated protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Nervous system diseases Other nervous and sensory system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000813[ESCRT I complex] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0010008[endosome membrane] GO:0015031[protein transport] GO:0036258[multivesicular body assembly] GO:0043130[ubiquitin binding] GO:0043162[ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway] GO:0043231[intracellular membrane-bounded organelle] GO:0043328[protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway] GO:0090148[membrane fission]
Q9NZ09 [Direct mapping] Ubiquitin-associated protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Nervous system diseases Other nervous and sensory system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000813[ESCRT I complex] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0010008[endosome membrane] GO:0015031[protein transport] GO:0036258[multivesicular body assembly] GO:0043130[ubiquitin binding] GO:0043162[ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway] GO:0043231[intracellular membrane-bounded organelle] GO:0043328[protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway] GO:0090148[membrane fission]
A0A0D9SG79 [Direct mapping] Ubiquitin-associated protein 1
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SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Other nervous and sensory system diseases Protein evidence (Ezkurdia et al 2014)
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GO:0000813[ESCRT I complex] GO:0005515[protein binding] GO:0043130[ubiquitin binding] GO:0043162[ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
The Human Protein Atlas project is funded
