GENERAL INFORMATIONi
Gene namei SYK
Synonyms
Gene descriptioni Spleen associated tyrosine kinase
Protein classi Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Human disease related genes
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 9
Cytoband q22.2
Chromosome location (bp) 90801787 - 90898549
Number of transcriptsi 4
Ensembl ENSG00000165025 (version 109)
Entrez gene 6850
HGNC HGNC:11491
UniProt P43405 (UniProt - Evidence at protein level)
neXtProt NX_P43405
GeneCards SYK
Antibodypedia SYK antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development 1, 2. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK 3, 4, 5, 6. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition 7. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 8. Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion 9. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Also plays a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). show less
Molecular function (UniProt)i Kinase, Transferase, Tyrosine-protein kinase
Biological process (UniProt)i Adaptive immunity, Angiogenesis, Host-virus interaction, Immunity, Innate immunity
Ligand (UniProt)i ATP-binding, Nucleotide-binding
Gene summary (Entrez)i This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
SYK-201
ENSP00000364898
ENST00000375746
P43405
[Direct mapping] Tyrosine-protein kinase SYK
Show all
A0A024R244
[Target identity:100%; Query identity:100%] Tyrosine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Immune system diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001775 [cell activation]
GO:0001784 [phosphotyrosine residue binding]
GO:0001945 [lymph vessel development]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002281 [macrophage activation involved in immune response]
GO:0002283 [neutrophil activation involved in immune response]
GO:0002366 [leukocyte activation involved in immune response]
GO:0002376 [immune system process]
GO:0002554 [serotonin secretion by platelet]
GO:0002696 [positive regulation of leukocyte activation]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006606 [protein import into nucleus]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009887 [animal organ morphogenesis]
GO:0010543 [regulation of platelet activation]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016020 [membrane]
GO:0016170 [interleukin-15 receptor binding]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030593 [neutrophil chemotaxis]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031623 [receptor internalization]
GO:0032009 [early phagosome]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0032928 [regulation of superoxide anion generation]
GO:0032930 [positive regulation of superoxide anion generation]
GO:0032991 [protein-containing complex]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038156 [interleukin-3-mediated signaling pathway]
GO:0042101 [T cell receptor complex]
GO:0042742 [defense response to bacterium]
GO:0043274 [phospholipase binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043306 [positive regulation of mast cell degranulation]
GO:0043313 [regulation of neutrophil degranulation]
GO:0045087 [innate immune response]
GO:0045579 [positive regulation of B cell differentiation]
GO:0045780 [positive regulation of bone resorption]
GO:0046641 [positive regulation of alpha-beta T cell proliferation]
GO:0048514 [blood vessel morphogenesis]
GO:0050764 [regulation of phagocytosis]
GO:0050778 [positive regulation of immune response]
GO:0050853 [B cell receptor signaling pathway]
GO:0051090 [regulation of DNA-binding transcription factor activity]
GO:0051712 [positive regulation of killing of cells of another organism]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0071226 [cellular response to molecule of fungal origin]
GO:0071396 [cellular response to lipid]
GO:0071404 [cellular response to low-density lipoprotein particle stimulus]
GO:0071639 [positive regulation of monocyte chemotactic protein-1 production]
GO:0090237 [regulation of arachidonic acid secretion]
GO:0090330 [regulation of platelet aggregation]
GO:0097110 [scaffold protein binding]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1990858 [cellular response to lectin]
Show all
 635 aa
72.1 kDa 		No 0
SYK-202
ENSP00000364899
ENST00000375747
P43405
[Direct mapping] Tyrosine-protein kinase SYK
Show all
A0A024R273
[Target identity:100%; Query identity:100%] Tyrosine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Immune system diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001775 [cell activation]
GO:0001784 [phosphotyrosine residue binding]
GO:0001945 [lymph vessel development]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002281 [macrophage activation involved in immune response]
GO:0002283 [neutrophil activation involved in immune response]
GO:0002366 [leukocyte activation involved in immune response]
GO:0002376 [immune system process]
GO:0002554 [serotonin secretion by platelet]
GO:0002696 [positive regulation of leukocyte activation]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006606 [protein import into nucleus]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009887 [animal organ morphogenesis]
GO:0010543 [regulation of platelet activation]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016020 [membrane]
GO:0016170 [interleukin-15 receptor binding]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030593 [neutrophil chemotaxis]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031623 [receptor internalization]
GO:0032009 [early phagosome]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0032928 [regulation of superoxide anion generation]
GO:0032930 [positive regulation of superoxide anion generation]
GO:0032991 [protein-containing complex]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038156 [interleukin-3-mediated signaling pathway]
GO:0042101 [T cell receptor complex]
GO:0042742 [defense response to bacterium]
GO:0043274 [phospholipase binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043306 [positive regulation of mast cell degranulation]
GO:0043313 [regulation of neutrophil degranulation]
GO:0045087 [innate immune response]
GO:0045579 [positive regulation of B cell differentiation]
GO:0045780 [positive regulation of bone resorption]
GO:0046641 [positive regulation of alpha-beta T cell proliferation]
GO:0048514 [blood vessel morphogenesis]
GO:0050764 [regulation of phagocytosis]
GO:0050778 [positive regulation of immune response]
GO:0050853 [B cell receptor signaling pathway]
GO:0051090 [regulation of DNA-binding transcription factor activity]
GO:0051712 [positive regulation of killing of cells of another organism]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0071226 [cellular response to molecule of fungal origin]
GO:0071396 [cellular response to lipid]
GO:0071404 [cellular response to low-density lipoprotein particle stimulus]
GO:0071639 [positive regulation of monocyte chemotactic protein-1 production]
GO:0090237 [regulation of arachidonic acid secretion]
GO:0090330 [regulation of platelet aggregation]
GO:0097110 [scaffold protein binding]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1990858 [cellular response to lectin]
Show all
 612 aa
69.5 kDa 		No 0
SYK-203
ENSP00000364904
ENST00000375751
P43405
[Direct mapping] Tyrosine-protein kinase SYK
Show all
A0A024R273
[Target identity:100%; Query identity:100%] Tyrosine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Immune system diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001775 [cell activation]
GO:0001784 [phosphotyrosine residue binding]
GO:0001945 [lymph vessel development]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002281 [macrophage activation involved in immune response]
GO:0002283 [neutrophil activation involved in immune response]
GO:0002366 [leukocyte activation involved in immune response]
GO:0002376 [immune system process]
GO:0002554 [serotonin secretion by platelet]
GO:0002696 [positive regulation of leukocyte activation]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006606 [protein import into nucleus]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009887 [animal organ morphogenesis]
GO:0010543 [regulation of platelet activation]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016020 [membrane]
GO:0016170 [interleukin-15 receptor binding]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030593 [neutrophil chemotaxis]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031623 [receptor internalization]
GO:0032009 [early phagosome]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0032928 [regulation of superoxide anion generation]
GO:0032930 [positive regulation of superoxide anion generation]
GO:0032991 [protein-containing complex]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038156 [interleukin-3-mediated signaling pathway]
GO:0042101 [T cell receptor complex]
GO:0042742 [defense response to bacterium]
GO:0043274 [phospholipase binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043306 [positive regulation of mast cell degranulation]
GO:0043313 [regulation of neutrophil degranulation]
GO:0045087 [innate immune response]
GO:0045579 [positive regulation of B cell differentiation]
GO:0045780 [positive regulation of bone resorption]
GO:0046641 [positive regulation of alpha-beta T cell proliferation]
GO:0048514 [blood vessel morphogenesis]
GO:0050764 [regulation of phagocytosis]
GO:0050778 [positive regulation of immune response]
GO:0050853 [B cell receptor signaling pathway]
GO:0051090 [regulation of DNA-binding transcription factor activity]
GO:0051712 [positive regulation of killing of cells of another organism]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0071226 [cellular response to molecule of fungal origin]
GO:0071396 [cellular response to lipid]
GO:0071404 [cellular response to low-density lipoprotein particle stimulus]
GO:0071639 [positive regulation of monocyte chemotactic protein-1 production]
GO:0090237 [regulation of arachidonic acid secretion]
GO:0090330 [regulation of platelet aggregation]
GO:0097110 [scaffold protein binding]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1990858 [cellular response to lectin]
Show all
 612 aa
69.5 kDa 		No 0
SYK-204
ENSP00000364907
ENST00000375754
P43405
[Direct mapping] Tyrosine-protein kinase SYK
Show all
A0A024R244
[Target identity:100%; Query identity:100%] Tyrosine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Immune system diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001775 [cell activation]
GO:0001784 [phosphotyrosine residue binding]
GO:0001819 [positive regulation of cytokine production]
GO:0001820 [serotonin secretion]
GO:0001945 [lymph vessel development]
GO:0002092 [positive regulation of receptor internalization]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002281 [macrophage activation involved in immune response]
GO:0002283 [neutrophil activation involved in immune response]
GO:0002366 [leukocyte activation involved in immune response]
GO:0002376 [immune system process]
GO:0002554 [serotonin secretion by platelet]
GO:0002696 [positive regulation of leukocyte activation]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006606 [protein import into nucleus]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007167 [enzyme-linked receptor protein signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009887 [animal organ morphogenesis]
GO:0010543 [regulation of platelet activation]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016020 [membrane]
GO:0016170 [interleukin-15 receptor binding]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019370 [leukotriene biosynthetic process]
GO:0019722 [calcium-mediated signaling]
GO:0019815 [B cell receptor complex]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030183 [B cell differentiation]
GO:0030593 [neutrophil chemotaxis]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031623 [receptor internalization]
GO:0032009 [early phagosome]
GO:0032481 [positive regulation of type I interferon production]
GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032752 [positive regulation of interleukin-3 production]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0032765 [positive regulation of mast cell cytokine production]
GO:0032928 [regulation of superoxide anion generation]
GO:0032930 [positive regulation of superoxide anion generation]
GO:0032991 [protein-containing complex]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0035325 [Toll-like receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038156 [interleukin-3-mediated signaling pathway]
GO:0042101 [T cell receptor complex]
GO:0042169 [SH2 domain binding]
GO:0042492 [gamma-delta T cell differentiation]
GO:0042742 [defense response to bacterium]
GO:0043274 [phospholipase binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043303 [mast cell degranulation]
GO:0043306 [positive regulation of mast cell degranulation]
GO:0043313 [regulation of neutrophil degranulation]
GO:0043366 [beta selection]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0045087 [innate immune response]
GO:0045579 [positive regulation of B cell differentiation]
GO:0045588 [positive regulation of gamma-delta T cell differentiation]
GO:0045780 [positive regulation of bone resorption]
GO:0046638 [positive regulation of alpha-beta T cell differentiation]
GO:0046641 [positive regulation of alpha-beta T cell proliferation]
GO:0046777 [protein autophosphorylation]
GO:0048514 [blood vessel morphogenesis]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050764 [regulation of phagocytosis]
GO:0050778 [positive regulation of immune response]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0050853 [B cell receptor signaling pathway]
GO:0051090 [regulation of DNA-binding transcription factor activity]
GO:0051649 [establishment of localization in cell]
GO:0051712 [positive regulation of killing of cells of another organism]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0071226 [cellular response to molecule of fungal origin]
GO:0071396 [cellular response to lipid]
GO:0071404 [cellular response to low-density lipoprotein particle stimulus]
GO:0071639 [positive regulation of monocyte chemotactic protein-1 production]
GO:0090237 [regulation of arachidonic acid secretion]
GO:0090330 [regulation of platelet aggregation]
GO:0097110 [scaffold protein binding]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:0140677 [molecular function activator activity]
GO:1990858 [cellular response to lectin]
Show all
 635 aa
72.1 kDa 		No 0

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