We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
q22.32
Chromosome location (bp)
94603133 - 94640249
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Allosteric enzyme, Hydrolase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Carbohydrate metabolism, Gluconeogenesis
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Magnesium, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Metabolic proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Congenital disorders of carbohydrate metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0003824[catalytic activity] GO:0005515[protein binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005975[carbohydrate metabolic process] GO:0005986[sucrose biosynthetic process] GO:0006000[fructose metabolic process] GO:0006002[fructose 6-phosphate metabolic process] GO:0006094[gluconeogenesis] GO:0006111[regulation of gluconeogenesis] GO:0008152[metabolic process] GO:0009409[response to cold] GO:0016208[AMP binding] GO:0016311[dephosphorylation] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0030308[negative regulation of cell growth] GO:0030388[fructose 1,6-bisphosphate metabolic process] GO:0031667[response to nutrient levels] GO:0032869[cellular response to insulin stimulus] GO:0042132[fructose 1,6-bisphosphate 1-phosphatase activity] GO:0042578[phosphoric ester hydrolase activity] GO:0042802[identical protein binding] GO:0045820[negative regulation of glycolytic process] GO:0046580[negative regulation of Ras protein signal transduction] GO:0046872[metal ion binding] GO:0048029[monosaccharide binding] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070062[extracellular exosome] GO:0071286[cellular response to magnesium ion] GO:0071320[cellular response to cAMP] GO:0071466[cellular response to xenobiotic stimulus] GO:0071475[cellular hyperosmotic salinity response] GO:0071477[cellular hypotonic salinity response] GO:0097403[cellular response to raffinose] GO:1901558[response to metformin] GO:1904628[cellular response to phorbol 13-acetate 12-myristate]
Metabolic proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of carbohydrate metabolism Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Metabolic proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Congenital disorders of carbohydrate metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0003824[catalytic activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005975[carbohydrate metabolic process] GO:0005986[sucrose biosynthetic process] GO:0006000[fructose metabolic process] GO:0006002[fructose 6-phosphate metabolic process] GO:0006094[gluconeogenesis] GO:0006111[regulation of gluconeogenesis] GO:0008152[metabolic process] GO:0016208[AMP binding] GO:0016311[dephosphorylation] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0030308[negative regulation of cell growth] GO:0030388[fructose 1,6-bisphosphate metabolic process] GO:0042132[fructose 1,6-bisphosphate 1-phosphatase activity] GO:0042578[phosphoric ester hydrolase activity] GO:0042802[identical protein binding] GO:0045820[negative regulation of glycolytic process] GO:0046580[negative regulation of Ras protein signal transduction] GO:0046872[metal ion binding] GO:0048029[monosaccharide binding] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070062[extracellular exosome] GO:0071286[cellular response to magnesium ion] GO:0071466[cellular response to xenobiotic stimulus]
Metabolic proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of carbohydrate metabolism Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
