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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q26.11
Chromosome location (bp)
119167720 - 119178812
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides 1,2,3,4. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol 5. Required for the maintenance of physical strength (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Antioxidant, Oxidoreductase, Peroxidase
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001893[maternal placenta development] GO:0004601[peroxidase activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005768[endosome] GO:0005769[early endosome] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0006979[response to oxidative stress] GO:0007005[mitochondrion organization] GO:0008022[protein C-terminus binding] GO:0008284[positive regulation of cell population proliferation] GO:0008379[thioredoxin peroxidase activity] GO:0008785[alkyl hydroperoxide reductase activity] GO:0016209[antioxidant activity] GO:0016491[oxidoreductase activity] GO:0018171[peptidyl-cysteine oxidation] GO:0019900[kinase binding] GO:0019901[protein kinase binding] GO:0030099[myeloid cell differentiation] GO:0032496[response to lipopolysaccharide] GO:0032991[protein-containing complex] GO:0033673[negative regulation of kinase activity] GO:0034599[cellular response to oxidative stress] GO:0034614[cellular response to reactive oxygen species] GO:0042542[response to hydrogen peroxide] GO:0042744[hydrogen peroxide catabolic process] GO:0042802[identical protein binding] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045454[cell redox homeostasis] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051881[regulation of mitochondrial membrane potential] GO:0051920[peroxiredoxin activity] GO:0098869[cellular oxidant detoxification] GO:0140824[thioredoxin-dependent peroxiredoxin activity]
The Human Protein Atlas project is funded
