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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Beta-transducin repeat containing E3 ubiquitin protein ligase
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q24.32
Chromosome location (bp)
101354033 - 101557321
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25. Recognizes and binds to phosphorylated target proteins 26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling 51,52. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2 53,54,55,56. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription 57,58,59,60. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' 61. The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation 62,63,64. SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis 65,66. SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 67. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3 68. Mediates ubiquitination of REST, thereby leading to its proteasomal degradation 69,70. SCF(BTRC) mediates the ubiquitination and subsequent proteasomal degradation of KLF4; thereby negatively regulating cell pluripotency maintenance and embryogenesis (By similarity). SCF(BTRC) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF 71,72,73,74,75....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Ligase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q5T1W7 [Direct mapping] F-box/WD repeat-containing protein 1A
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Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006470[protein dephosphorylation] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0007165[signal transduction] GO:0008013[beta-catenin binding] GO:0016055[Wnt signaling pathway] GO:0016567[protein ubiquitination] GO:0016874[ligase activity] GO:0019005[SCF ubiquitin ligase complex] GO:0030163[protein catabolic process] GO:0031146[SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0031648[protein destabilization] GO:0033598[mammary gland epithelial cell proliferation] GO:0042752[regulation of circadian rhythm] GO:0042753[positive regulation of circadian rhythm] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0045309[protein phosphorylated amino acid binding] GO:0045862[positive regulation of proteolysis] GO:0045879[negative regulation of smoothened signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0046983[protein dimerization activity] GO:0048511[rhythmic process] GO:0051726[regulation of cell cycle] GO:0060444[branching involved in mammary gland duct morphogenesis] GO:0060828[regulation of canonical Wnt signaling pathway] GO:0061136[regulation of proteasomal protein catabolic process] GO:0061630[ubiquitin protein ligase activity] GO:0070936[protein K48-linked ubiquitination] GO:0071407[cellular response to organic cyclic compound] GO:1904668[positive regulation of ubiquitin protein ligase activity] GO:1990756[ubiquitin ligase-substrate adaptor activity] GO:1990757[ubiquitin ligase activator activity]
Q9Y297 [Direct mapping] F-box/WD repeat-containing protein 1A
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006470[protein dephosphorylation] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0007165[signal transduction] GO:0008013[beta-catenin binding] GO:0016055[Wnt signaling pathway] GO:0016567[protein ubiquitination] GO:0016874[ligase activity] GO:0019005[SCF ubiquitin ligase complex] GO:0031146[SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0031648[protein destabilization] GO:0042752[regulation of circadian rhythm] GO:0042753[positive regulation of circadian rhythm] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0045862[positive regulation of proteolysis] GO:0045879[negative regulation of smoothened signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0046983[protein dimerization activity] GO:0048511[rhythmic process] GO:0060828[regulation of canonical Wnt signaling pathway] GO:1904668[positive regulation of ubiquitin protein ligase activity] GO:1990756[ubiquitin ligase-substrate adaptor activity] GO:1990757[ubiquitin ligase activator activity]
The Human Protein Atlas project is funded
