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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q22
Chromosome location (bp)
54968727 - 55173632
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity)....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables syntaxin binding activity. Involved in several processes, including positive regulation of cell cycle G1/S phase transition; positive regulation of keratinocyte proliferation; and protein stabilization. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q6ZWJ1 [Direct mapping] Syntaxin-binding protein 4
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0006605[protein targeting] GO:0006974[cellular response to DNA damage stimulus] GO:0008286[insulin receptor signaling pathway] GO:0010827[regulation of glucose transmembrane transport] GO:0010838[positive regulation of keratinocyte proliferation] GO:0019905[syntaxin binding] GO:0031410[cytoplasmic vesicle] GO:0045335[phagocytic vesicle] GO:0050821[protein stabilization] GO:0061178[regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070062[extracellular exosome] GO:0071346[cellular response to interferon-gamma] GO:0098685[Schaffer collateral - CA1 synapse] GO:0099072[regulation of postsynaptic membrane neurotransmitter receptor levels] GO:1902808[positive regulation of cell cycle G1/S phase transition]
Q6ZWJ1 [Direct mapping] Syntaxin-binding protein 4
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0006974[cellular response to DNA damage stimulus] GO:0008286[insulin receptor signaling pathway] GO:0010838[positive regulation of keratinocyte proliferation] GO:0019905[syntaxin binding] GO:0031410[cytoplasmic vesicle] GO:0050821[protein stabilization] GO:0061178[regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070062[extracellular exosome] GO:1902808[positive regulation of cell cycle G1/S phase transition]
The Human Protein Atlas project is funded
