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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Enzymes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
p15.4
Chromosome location (bp)
6603708 - 6610874
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Receptor-proximal protein kinase regulating integrin-mediated signal transduction 1,2. May act as a mediator of inside-out integrin signaling 3. Focal adhesion protein part of the complex ILK-PINCH 4. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway 5. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells 6. Regulates cell motility by forming a complex with PARVB 7. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B 8,9....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q13418 [Direct mapping] Integrin-linked protein kinase
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V9HWF0 [Target identity:100%; Query identity:100%] Integrin-linked protein kinase
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Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0000902[cell morphogenesis] GO:0001658[branching involved in ureteric bud morphogenesis] GO:0001725[stress fiber] GO:0001934[positive regulation of protein phosphorylation] GO:0003151[outflow tract morphogenesis] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0007160[cell-matrix adhesion] GO:0007229[integrin-mediated signaling pathway] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0009967[positive regulation of signal transduction] GO:0010761[fibroblast migration] GO:0014044[Schwann cell development] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0019901[protein kinase binding] GO:0021675[nerve development] GO:0022011[myelination in peripheral nervous system] GO:0030017[sarcomere] GO:0030027[lamellipodium] GO:0030030[cell projection organization] GO:0030513[positive regulation of BMP signaling pathway] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034446[substrate adhesion-dependent cell spreading] GO:0042327[positive regulation of phosphorylation] GO:0042995[cell projection] GO:0043491[protein kinase B signaling] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045669[positive regulation of osteoblast differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0061351[neural precursor cell proliferation] GO:0070161[anchoring junction] GO:0070527[platelet aggregation] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0106310[protein serine kinase activity] GO:1900026[positive regulation of substrate adhesion-dependent cell spreading] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:2000178[negative regulation of neural precursor cell proliferation]
Q13418 [Direct mapping] Integrin-linked protein kinase
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V9HWF0 [Target identity:100%; Query identity:100%] Integrin-linked protein kinase
Show all
Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q13418 [Direct mapping] Integrin-linked protein kinase
Show all
V9HWF0 [Target identity:100%; Query identity:100%] Integrin-linked protein kinase
Show all
Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Q13418 [Direct mapping] Integrin-linked protein kinase
Show all
Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Q13418 [Direct mapping] Integrin-linked protein kinase
Show all
Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
