GENERAL INFORMATIONi
Gene namei SMAD3
Synonyms HsT17436, JV15-2, MADH3
Gene descriptioni SMAD family member 3
Protein classi Cancer-related genes
Disease related genes
Human disease related genes
Transcription factors
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 15
Cytoband q22.33
Chromosome location (bp) 67063763 - 67195173
Number of transcriptsi 14
Ensembl ENSG00000166949 (version 109)
Entrez gene 4088
HGNC HGNC:6769
UniProt P84022 (UniProt - Evidence at protein level)
neXtProt NX_P84022
GeneCards SMAD3
Antibodypedia SMAD3 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. show less
Molecular function (UniProt)i DNA-binding
Biological process (UniProt)i Host-virus interaction, Transcription, Transcription regulation
Ligand (UniProt)i Metal-binding, Zinc
Gene summary (Entrez)i The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. This protein forms a complex with other SMAD proteins and binds DNA, functioning both as a transcription factor and tumor suppressor. Mutations in this gene are associated with aneurysms-osteoarthritis syndrome and Loeys-Dietz Syndrome 3. [provided by RefSeq, May 2022] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
SMAD3-201
ENSP00000332973
ENST00000327367
P84022
[Direct mapping] Mothers against decapentaplegic homolog 3
Show all
A0A024R5Z3
[Target identity:100%; Query identity:100%] Mothers against decapentaplegic homolog
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000165 [MAPK cascade]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001217 [DNA-binding transcription repressor activity]
GO:0001223 [transcription coactivator binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001501 [skeletal system development]
GO:0001649 [osteoblast differentiation]
GO:0001657 [ureteric bud development]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001707 [mesoderm formation]
GO:0001756 [somitogenesis]
GO:0001889 [liver development]
GO:0001947 [heart looping]
GO:0002076 [osteoblast development]
GO:0002520 [immune system development]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005634 [nucleus]
GO:0005637 [nuclear inner membrane]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006955 [immune response]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007183 [SMAD protein complex assembly]
GO:0007254 [JNK cascade]
GO:0007369 [gastrulation]
GO:0007492 [endoderm development]
GO:0008013 [beta-catenin binding]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009653 [anatomical structure morphogenesis]
GO:0009880 [embryonic pattern specification]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010694 [positive regulation of alkaline phosphatase activity]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016202 [regulation of striated muscle tissue development]
GO:0016922 [nuclear receptor binding]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0017151 [DEAD/H-box RNA helicase binding]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0023019 [signal transduction involved in regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030325 [adrenal gland development]
GO:0030335 [positive regulation of cell migration]
GO:0030501 [positive regulation of bone mineralization]
GO:0030878 [thyroid gland development]
GO:0031053 [primary miRNA processing]
GO:0031490 [chromatin DNA binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031962 [nuclear mineralocorticoid receptor binding]
GO:0032332 [positive regulation of chondrocyte differentiation]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032810 [sterol response element binding]
GO:0032909 [regulation of transforming growth factor beta2 production]
GO:0032916 [positive regulation of transforming growth factor beta3 production]
GO:0032924 [activin receptor signaling pathway]
GO:0032991 [protein-containing complex]
GO:0033689 [negative regulation of osteoblast proliferation]
GO:0035259 [nuclear glucocorticoid receptor binding]
GO:0038092 [nodal signaling pathway]
GO:0042060 [wound healing]
GO:0042110 [T cell activation]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043130 [ubiquitin binding]
GO:0043235 [receptor complex]
GO:0043425 [bHLH transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045216 [cell-cell junction organization]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0048340 [paraxial mesoderm morphogenesis]
GO:0048589 [developmental growth]
GO:0048617 [embryonic foregut morphogenesis]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0050678 [regulation of epithelial cell proliferation]
GO:0050728 [negative regulation of inflammatory response]
GO:0050776 [regulation of immune response]
GO:0050821 [protein stabilization]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051098 [regulation of binding]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0060039 [pericardium development]
GO:0060290 [transdifferentiation]
GO:0060395 [SMAD protein signal transduction]
GO:0061045 [negative regulation of wound healing]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0061767 [negative regulation of lung blood pressure]
GO:0070306 [lens fiber cell differentiation]
GO:0070410 [co-SMAD binding]
GO:0070411 [I-SMAD binding]
GO:0070412 [R-SMAD binding]
GO:0071141 [SMAD protein complex]
GO:0071144 [heteromeric SMAD protein complex]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0098586 [cellular response to virus]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901203 [positive regulation of extracellular matrix assembly]
GO:1902893 [regulation of miRNA transcription]
GO:1902895 [positive regulation of miRNA transcription]
GO:1903243 [negative regulation of cardiac muscle hypertrophy in response to stress]
GO:1990841 [promoter-specific chromatin binding]
Show all
 425 aa
48.1 kDa 		No 0
SMAD3-202
ENSP00000401133
ENST00000439724
P84022
[Direct mapping] Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001217 [DNA-binding transcription repressor activity]
GO:0001223 [transcription coactivator binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001666 [response to hypoxia]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005637 [nuclear inner membrane]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006955 [immune response]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007183 [SMAD protein complex assembly]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009653 [anatomical structure morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016922 [nuclear receptor binding]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0017151 [DEAD/H-box RNA helicase binding]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0031053 [primary miRNA processing]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031962 [nuclear mineralocorticoid receptor binding]
GO:0032810 [sterol response element binding]
GO:0032909 [regulation of transforming growth factor beta2 production]
GO:0032924 [activin receptor signaling pathway]
GO:0035259 [nuclear glucocorticoid receptor binding]
GO:0038092 [nodal signaling pathway]
GO:0042060 [wound healing]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043130 [ubiquitin binding]
GO:0043235 [receptor complex]
GO:0043425 [bHLH transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045216 [cell-cell junction organization]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0060395 [SMAD protein signal transduction]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070410 [co-SMAD binding]
GO:0070411 [I-SMAD binding]
GO:0070412 [R-SMAD binding]
GO:0071141 [SMAD protein complex]
GO:0071144 [heteromeric SMAD protein complex]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901203 [positive regulation of extracellular matrix assembly]
GO:1902893 [regulation of miRNA transcription]
GO:1902895 [positive regulation of miRNA transcription]
Show all
 381 aa
43.2 kDa 		No 0
SMAD3-203
ENSP00000445348
ENST00000537194
P84022
[Direct mapping] Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001217 [DNA-binding transcription repressor activity]
GO:0001223 [transcription coactivator binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001666 [response to hypoxia]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005637 [nuclear inner membrane]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006955 [immune response]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007183 [SMAD protein complex assembly]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009653 [anatomical structure morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016922 [nuclear receptor binding]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0017151 [DEAD/H-box RNA helicase binding]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0031053 [primary miRNA processing]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031962 [nuclear mineralocorticoid receptor binding]
GO:0032810 [sterol response element binding]
GO:0032909 [regulation of transforming growth factor beta2 production]
GO:0032924 [activin receptor signaling pathway]
GO:0035259 [nuclear glucocorticoid receptor binding]
GO:0038092 [nodal signaling pathway]
GO:0042060 [wound healing]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043130 [ubiquitin binding]
GO:0043235 [receptor complex]
GO:0043425 [bHLH transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045216 [cell-cell junction organization]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0060395 [SMAD protein signal transduction]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070410 [co-SMAD binding]
GO:0070411 [I-SMAD binding]
GO:0070412 [R-SMAD binding]
GO:0071141 [SMAD protein complex]
GO:0071144 [heteromeric SMAD protein complex]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901203 [positive regulation of extracellular matrix assembly]
GO:1902893 [regulation of miRNA transcription]
GO:1902895 [positive regulation of miRNA transcription]
Show all
 230 aa
25.7 kDa 		No 0
SMAD3-204
ENSP00000437757
ENST00000540846
P84022
[Direct mapping] Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001217 [DNA-binding transcription repressor activity]
GO:0001223 [transcription coactivator binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001666 [response to hypoxia]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005637 [nuclear inner membrane]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006955 [immune response]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007183 [SMAD protein complex assembly]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009653 [anatomical structure morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016922 [nuclear receptor binding]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0017151 [DEAD/H-box RNA helicase binding]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0031053 [primary miRNA processing]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031962 [nuclear mineralocorticoid receptor binding]
GO:0032810 [sterol response element binding]
GO:0032909 [regulation of transforming growth factor beta2 production]
GO:0032924 [activin receptor signaling pathway]
GO:0035259 [nuclear glucocorticoid receptor binding]
GO:0038092 [nodal signaling pathway]
GO:0042060 [wound healing]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043130 [ubiquitin binding]
GO:0043235 [receptor complex]
GO:0043425 [bHLH transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045216 [cell-cell junction organization]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0060395 [SMAD protein signal transduction]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070410 [co-SMAD binding]
GO:0070411 [I-SMAD binding]
GO:0070412 [R-SMAD binding]
GO:0071141 [SMAD protein complex]
GO:0071144 [heteromeric SMAD protein complex]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901203 [positive regulation of extracellular matrix assembly]
GO:1902893 [regulation of miRNA transcription]
GO:1902895 [positive regulation of miRNA transcription]
Show all
 320 aa
35.9 kDa 		No 0
SMAD3-205
ENSP00000454165
ENST00000558428
H0YNV1
[Direct mapping] Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
Show all
 84 aa
9.3 kDa 		No 0
SMAD3-206
ENSP00000453684
ENST00000558739
H0YMP2
[Direct mapping] Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
Show all
 63 aa
7.3 kDa 		No 0
SMAD3-208
ENSP00000452767
ENST00000558827
H0YKE2
[Direct mapping] Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
Show all
 112 aa
12.5 kDa 		No 0
SMAD3-209
ENSP00000458060
ENST00000558894
H3BVD1
[Direct mapping] Mothers against decapentaplegic homolog
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0046872 [metal ion binding]
Show all
 213 aa
23.8 kDa 		No 0
SMAD3-210
ENSP00000453788
ENST00000559092
H0YMY0
[Direct mapping] Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
 96 aa
10.4 kDa 		No 0
SMAD3-211
ENSP00000453082
ENST00000559460
H0YL71
[Direct mapping] Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
Show all
 92 aa
10.4 kDa 		No 0
SMAD3-213
ENSP00000455095
ENST00000560175
H3BP09
[Direct mapping] Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
Show all
 114 aa
12.7 kDa 		No 0
SMAD3-215
ENSP00000455540
ENST00000560424
H3BQ00
[Direct mapping] Mothers against decapentaplegic homolog 3
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
Show all
 156 aa
17.2 kDa 		No 0
SMAD3-216
ENSP00000505445
ENST00000679624
P84022
[Direct mapping] Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001217 [DNA-binding transcription repressor activity]
GO:0001223 [transcription coactivator binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001666 [response to hypoxia]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005637 [nuclear inner membrane]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006955 [immune response]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007183 [SMAD protein complex assembly]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009653 [anatomical structure morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016922 [nuclear receptor binding]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0017151 [DEAD/H-box RNA helicase binding]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0031053 [primary miRNA processing]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031962 [nuclear mineralocorticoid receptor binding]
GO:0032810 [sterol response element binding]
GO:0032909 [regulation of transforming growth factor beta2 production]
GO:0032924 [activin receptor signaling pathway]
GO:0035259 [nuclear glucocorticoid receptor binding]
GO:0038092 [nodal signaling pathway]
GO:0042060 [wound healing]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043130 [ubiquitin binding]
GO:0043235 [receptor complex]
GO:0043425 [bHLH transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045216 [cell-cell junction organization]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0060395 [SMAD protein signal transduction]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070410 [co-SMAD binding]
GO:0070411 [I-SMAD binding]
GO:0070412 [R-SMAD binding]
GO:0071141 [SMAD protein complex]
GO:0071144 [heteromeric SMAD protein complex]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901203 [positive regulation of extracellular matrix assembly]
GO:1902893 [regulation of miRNA transcription]
GO:1902895 [positive regulation of miRNA transcription]
Show all
 320 aa
35.9 kDa 		No 0
SMAD3-218
ENSP00000505641
ENST00000681239
P84022
[Direct mapping] Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001217 [DNA-binding transcription repressor activity]
GO:0001223 [transcription coactivator binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001666 [response to hypoxia]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005637 [nuclear inner membrane]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006955 [immune response]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007183 [SMAD protein complex assembly]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009653 [anatomical structure morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016922 [nuclear receptor binding]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0017151 [DEAD/H-box RNA helicase binding]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0031053 [primary miRNA processing]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031962 [nuclear mineralocorticoid receptor binding]
GO:0032810 [sterol response element binding]
GO:0032909 [regulation of transforming growth factor beta2 production]
GO:0032924 [activin receptor signaling pathway]
GO:0035259 [nuclear glucocorticoid receptor binding]
GO:0038092 [nodal signaling pathway]
GO:0042060 [wound healing]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043130 [ubiquitin binding]
GO:0043235 [receptor complex]
GO:0043425 [bHLH transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045216 [cell-cell junction organization]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0060395 [SMAD protein signal transduction]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070410 [co-SMAD binding]
GO:0070411 [I-SMAD binding]
GO:0070412 [R-SMAD binding]
GO:0071141 [SMAD protein complex]
GO:0071144 [heteromeric SMAD protein complex]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901203 [positive regulation of extracellular matrix assembly]
GO:1902893 [regulation of miRNA transcription]
GO:1902895 [positive regulation of miRNA transcription]
Show all
 320 aa
35.9 kDa 		No 0

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The Human Protein Atlas

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