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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Human disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
p21.2
Chromosome location (bp)
23678697 - 23682938
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Human disease related genes Cancers Cancers of male genital organs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001655[urogenital system development] GO:0001656[metanephros development] GO:0001756[somitogenesis] GO:0001934[positive regulation of protein phosphorylation] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007431[salivary gland development] GO:0007507[heart development] GO:0008284[positive regulation of cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0008584[male gonad development] GO:0008656[cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010942[positive regulation of cell death] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0030154[cell differentiation] GO:0030331[nuclear estrogen receptor binding] GO:0030521[androgen receptor signaling pathway] GO:0030850[prostate gland development] GO:0032880[regulation of protein localization] GO:0033574[response to testosterone] GO:0035907[dorsal aorta development] GO:0042826[histone deacetylase binding] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043491[protein kinase B signaling] GO:0043565[sequence-specific DNA binding] GO:0043569[negative regulation of insulin-like growth factor receptor signaling pathway] GO:0043621[protein self-association] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045931[positive regulation of mitotic cell cycle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048754[branching morphogenesis of an epithelial tube] GO:0050673[epithelial cell proliferation] GO:0050680[negative regulation of epithelial cell proliferation] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051781[positive regulation of cell division] GO:0060037[pharyngeal system development] GO:0060442[branching involved in prostate gland morphogenesis] GO:0060664[epithelial cell proliferation involved in salivary gland morphogenesis] GO:0060767[epithelial cell proliferation involved in prostate gland development] GO:0060770[negative regulation of epithelial cell proliferation involved in prostate gland development] GO:0071347[cellular response to interleukin-1] GO:0071356[cellular response to tumor necrosis factor] GO:0071383[cellular response to steroid hormone stimulus] GO:0071456[cellular response to hypoxia] GO:0071466[cellular response to xenobiotic stimulus] GO:0090734[site of DNA damage] GO:0097162[MADS box domain binding] GO:0140297[DNA-binding transcription factor binding] GO:0140416[transcription regulator inhibitor activity] GO:1902807[negative regulation of cell cycle G1/S phase transition] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000836[positive regulation of androgen secretion] GO:2001022[positive regulation of response to DNA damage stimulus] GO:2001235[positive regulation of apoptotic signaling pathway] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Human disease related genes Cancers Cancers of male genital organs Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001934[positive regulation of protein phosphorylation] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007431[salivary gland development] GO:0008284[positive regulation of cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0008656[cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010942[positive regulation of cell death] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0030154[cell differentiation] GO:0030331[nuclear estrogen receptor binding] GO:0030521[androgen receptor signaling pathway] GO:0032880[regulation of protein localization] GO:0033574[response to testosterone] GO:0042826[histone deacetylase binding] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043491[protein kinase B signaling] GO:0043565[sequence-specific DNA binding] GO:0043569[negative regulation of insulin-like growth factor receptor signaling pathway] GO:0043621[protein self-association] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045931[positive regulation of mitotic cell cycle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048754[branching morphogenesis of an epithelial tube] GO:0050680[negative regulation of epithelial cell proliferation] GO:0051781[positive regulation of cell division] GO:0060442[branching involved in prostate gland morphogenesis] GO:0060664[epithelial cell proliferation involved in salivary gland morphogenesis] GO:0060770[negative regulation of epithelial cell proliferation involved in prostate gland development] GO:0071347[cellular response to interleukin-1] GO:0071356[cellular response to tumor necrosis factor] GO:0071383[cellular response to steroid hormone stimulus] GO:0071456[cellular response to hypoxia] GO:0071466[cellular response to xenobiotic stimulus] GO:0090734[site of DNA damage] GO:0140297[DNA-binding transcription factor binding] GO:0140416[transcription regulator inhibitor activity] GO:1902807[negative regulation of cell cycle G1/S phase transition] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000836[positive regulation of androgen secretion] GO:2001022[positive regulation of response to DNA damage stimulus] GO:2001235[positive regulation of apoptotic signaling pathway] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
The Human Protein Atlas project is funded
