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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q21.33
Chromosome location (bp)
49404049 - 49414905
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus 1,2,3,4. Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity)....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
DNA synthesis, Host-virus interaction
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Transporters Accessory Factors Involved in Transport MEMSAT3 predicted membrane proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Predicted intracellular proteins Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001649[osteoblast differentiation] GO:0001850[complement component C3a binding] GO:0001851[complement component C3b binding] GO:0002639[positive regulation of immunoglobulin production] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0005769[early endosome] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0007005[mitochondrion organization] GO:0007165[signal transduction] GO:0007202[activation of phospholipase C activity] GO:0008022[protein C-terminus binding] GO:0008285[negative regulation of cell population proliferation] GO:0009986[cell surface] GO:0010628[positive regulation of gene expression] GO:0010942[positive regulation of cell death] GO:0010944[negative regulation of transcription by competitive promoter binding] GO:0016020[membrane] GO:0016575[histone deacetylation] GO:0019899[enzyme binding] GO:0023035[CD40 signaling pathway] GO:0030308[negative regulation of cell growth] GO:0031871[proteinase activated receptor binding] GO:0032740[positive regulation of interleukin-17 production] GO:0035632[mitochondrial prohibitin complex] GO:0039529[RIG-I signaling pathway] GO:0042113[B cell activation] GO:0042177[negative regulation of protein catabolic process] GO:0042826[histone deacetylase binding] GO:0042981[regulation of apoptotic process] GO:0044830[modulation by host of viral RNA genome replication] GO:0045745[positive regulation of G protein-coupled receptor signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045917[positive regulation of complement activation] GO:0046718[viral entry into host cell] GO:0046982[protein heterodimerization activity] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050821[protein stabilization] GO:0050847[progesterone receptor signaling pathway] GO:0051897[positive regulation of protein kinase B signaling] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0070062[extracellular exosome] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071354[cellular response to interleukin-6] GO:0071897[DNA biosynthetic process] GO:0072538[T-helper 17 type immune response] GO:0140374[antiviral innate immune response] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:1990051[activation of protein kinase C activity] GO:2000323[negative regulation of glucocorticoid receptor signaling pathway]
Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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