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DPEP2
HPA
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  • SUMMARY

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  • DPEP2
PROTEIN SUMMARY GENE INFORMATION RNA DATA ANTIBODY DATA
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

DPEP2
Synonyms
Gene descriptioni

Full gene name according to HGNC.

Dipeptidase 2
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Enzymes
Metabolic proteins
Plasma proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Membrane, Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 16
Cytoband q22.1
Chromosome location (bp) 67987394 - 68000586
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

6
Ensembl ENSG00000167261 (version 109)
Entrez gene 64174
HGNC HGNC:23028
UniProt Q9H4A9 (UniProt - Evidence at protein level)
neXtProt NX_Q9H4A9
GeneCards DPEP2
Antibodypedia DPEP2 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i

Useful information about the protein provided by UniProt.

Dipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) 1. Hydrolyzes cystinyl-bis-glycine 2.... show less
Molecular function (UniProt)i

Keywords assigned by UniProt to proteins due to their particular molecular function.

Dipeptidase, Hydrolase, Metalloprotease, Protease
Biological process (UniProt)i

Keywords assigned by UniProt to proteins because they are involved in a particular biological process.

Lipid metabolism
Ligand (UniProt)i

Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.

Metal-binding, Zinc
Gene summary (Entrez)i

Useful information about the gene from Entrez

DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003).[supplied by OMIM, Mar 2008]... show less
PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
DPEP2-202
ENSP00000377430
ENST00000393847
Q9H4A9
[Direct mapping] Dipeptidase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Metabolic proteins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0006629 [lipid metabolic process]
GO:0006691 [leukotriene metabolic process]
GO:0008233 [peptidase activity]
GO:0008237 [metallopeptidase activity]
GO:0008238 [exopeptidase activity]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0016805 [dipeptidase activity]
GO:0046872 [metal ion binding]
GO:0070573 [metallodipeptidase activity]
GO:1901749 [leukotriene D4 catabolic process]
Show all
486 aa
53.4 kDa
Yes 1
DPEP2-203
ENSP00000460169
ENST00000572624
I3L348
[Direct mapping] Dipeptidase
Show all
Metabolic proteins
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
   DeepTMHMM predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0016020 [membrane]
GO:0070573 [metallodipeptidase activity]
Show all
137 aa
14.9 kDa
Yes 0
DPEP2-204
ENSP00000458977
ENST00000572888
Q9H4A9
[Direct mapping] Dipeptidase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Metabolic proteins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0006629 [lipid metabolic process]
GO:0006691 [leukotriene metabolic process]
GO:0008233 [peptidase activity]
GO:0008237 [metallopeptidase activity]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0016805 [dipeptidase activity]
GO:0046872 [metal ion binding]
GO:0070573 [metallodipeptidase activity]
GO:1901749 [leukotriene D4 catabolic process]
Show all
486 aa
53.4 kDa
Yes 1
DPEP2-205
ENSP00000463604
ENST00000573808
J3QLL2
[Direct mapping] Dipeptidase
Show all
Metabolic proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008237 [metallopeptidase activity]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0016805 [dipeptidase activity]
GO:0046872 [metal ion binding]
GO:0070573 [metallodipeptidase activity]
Show all
161 aa
17.8 kDa
No 0
DPEP2-207
ENSP00000461250
ENST00000574865
I3L4H3
[Direct mapping] Dipeptidase
Show all
Metabolic proteins
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
   DeepTMHMM predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0070573 [metallodipeptidase activity]
Show all
114 aa
12.4 kDa
Yes 0
DPEP2-209
ENSP00000462652
ENST00000575510
J3KSU4
[Direct mapping] Dipeptidase
Show all
Metabolic proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008237 [metallopeptidase activity]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0016805 [dipeptidase activity]
GO:0046872 [metal ion binding]
GO:0070573 [metallodipeptidase activity]
Show all
122 aa
13 kDa
No 0

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