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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
16
Cytoband
q24.3
Chromosome location (bp)
88803789 - 88809258
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Required for both DNA replication and mitosis 1,2,3,4,5. DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) 6. Required also for mitosis by promoting stable kinetochore-microtubule attachments 7. Potential oncogene (By similarity)....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell cycle, Cell division, DNA replication, Mitosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9H211 [Direct mapping] DNA replication factor Cdt1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000076[DNA replication checkpoint signaling] GO:0000278[mitotic cell cycle] GO:0000775[chromosome, centromeric region] GO:0000776[kinetochore] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0006260[DNA replication] GO:0007049[cell cycle] GO:0007059[chromosome segregation] GO:0016604[nuclear body] GO:0030174[regulation of DNA-templated DNA replication initiation] GO:0031334[positive regulation of protein-containing complex assembly] GO:0033044[regulation of chromosome organization] GO:0033262[regulation of nuclear cell cycle DNA replication] GO:0035563[positive regulation of chromatin binding] GO:0045740[positive regulation of DNA replication] GO:0045786[negative regulation of cell cycle] GO:0051301[cell division] GO:0051315[attachment of mitotic spindle microtubules to kinetochore] GO:0051383[kinetochore organization] GO:0070182[DNA polymerase binding] GO:0071163[DNA replication preinitiation complex assembly] GO:0072708[response to sorbitol] GO:1902426[deactivation of mitotic spindle assembly checkpoint] GO:1902595[regulation of DNA replication origin binding] GO:1905341[negative regulation of protein localization to kinetochore] GO:1905342[positive regulation of protein localization to kinetochore] GO:2000104[negative regulation of DNA-templated DNA replication] GO:2000105[positive regulation of DNA-templated DNA replication]
H3BSY1 [Direct mapping] DNA replication factor Cdt1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
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GO:0003677[DNA binding] GO:0005634[nucleus] GO:0030174[regulation of DNA-templated DNA replication initiation] GO:0071163[DNA replication preinitiation complex assembly]
The Human Protein Atlas project is funded
