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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
p13.13
Chromosome location (bp)
12796820 - 12801800
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Antioxidant, Oxidoreductase, Peroxidase
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
V9HW12 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 2a; Peroxiredoxin 2, isoform CRA_b
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Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002357[defense response to tumor cell] GO:0002536[respiratory burst involved in inflammatory response] GO:0004601[peroxidase activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006979[response to oxidative stress] GO:0008379[thioredoxin peroxidase activity] GO:0010310[regulation of hydrogen peroxide metabolic process] GO:0016209[antioxidant activity] GO:0016491[oxidoreductase activity] GO:0019430[removal of superoxide radicals] GO:0030194[positive regulation of blood coagulation] GO:0031665[negative regulation of lipopolysaccharide-mediated signaling pathway] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032496[response to lipopolysaccharide] GO:0034599[cellular response to oxidative stress] GO:0042098[T cell proliferation] GO:0042743[hydrogen peroxide metabolic process] GO:0042744[hydrogen peroxide catabolic process] GO:0042981[regulation of apoptotic process] GO:0043029[T cell homeostasis] GO:0043066[negative regulation of apoptotic process] GO:0043410[positive regulation of MAPK cascade] GO:0045321[leukocyte activation] GO:0045454[cell redox homeostasis] GO:0045581[negative regulation of T cell differentiation] GO:0048538[thymus development] GO:0051920[peroxiredoxin activity] GO:0070062[extracellular exosome] GO:0097191[extrinsic apoptotic signaling pathway] GO:0140824[thioredoxin-dependent peroxiredoxin activity] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
The Human Protein Atlas project is funded
