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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
CD markers Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q25.1
Chromosome location (bp)
74466399 - 74484794
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation 1,2,3. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 4....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell adhesion, Immunity
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
CD markers Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins DeepSig predicted secreted proteins Predicted intracellular proteins Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001786[phosphatidylserine binding] GO:0002376[immune system process] GO:0004888[transmembrane signaling receptor activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0007155[cell adhesion] GO:0008429[phosphatidylethanolamine binding] GO:0016020[membrane] GO:0030889[negative regulation of B cell proliferation] GO:0032516[positive regulation of phosphoprotein phosphatase activity] GO:0033007[negative regulation of mast cell activation involved in immune response] GO:0034125[negative regulation of MyD88-dependent toll-like receptor signaling pathway] GO:0038023[signaling receptor activity] GO:0043305[negative regulation of mast cell degranulation] GO:0043407[negative regulation of MAP kinase activity] GO:0048147[negative regulation of fibroblast proliferation] GO:0050856[regulation of T cell receptor signaling pathway] GO:0050859[negative regulation of B cell receptor signaling pathway] GO:0051134[negative regulation of NK T cell activation] GO:0060101[negative regulation of phagocytosis, engulfment] GO:0070062[extracellular exosome] GO:0070821[tertiary granule membrane] GO:0101003[ficolin-1-rich granule membrane] GO:1902564[negative regulation of neutrophil activation] GO:1902567[negative regulation of eosinophil activation] GO:1902569[negative regulation of activation of Janus kinase activity] GO:2000417[negative regulation of eosinophil migration]
The Human Protein Atlas project is funded
