GENERAL INFORMATIONi
Gene namei CTNNB1
Synonyms armadillo, beta-catenin, CTNNB
Gene descriptioni Catenin beta 1
Protein classi Cancer-related genes
Disease related genes
Human disease related genes
Plasma proteins
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 3
Cytoband p22.1
Chromosome location (bp) 41194741 - 41260096
Number of transcriptsi 43
Ensembl ENSG00000168036 (version 109)
Entrez gene 1499
HGNC HGNC:2514
UniProt P35222 (UniProt - Evidence at protein level)
neXtProt NX_P35222
GeneCards CTNNB1
Antibodypedia CTNNB1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Key downstream component of the canonical Wnt signaling pathway 1, 2, 3, 4, 5, 6, 7, 8. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome 9, 10, 11, 12, 13, 14, 15, 16. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes 17, 18, 19, 20, 21, 22, 23, 24. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion 25. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization 26. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 27. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML 28. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). show less
Molecular function (UniProt)i Activator
Biological process (UniProt)i Cell adhesion, Host-virus interaction, Neurogenesis, Transcription, Transcription regulation, Wnt signaling pathway
Gene summary (Entrez)i The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
CTNNB1-201
ENSP00000344456
ENST00000349496
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000165 [MAPK cascade]
GO:0000209 [protein polyubiquitination]
GO:0000578 [embryonic axis specification]
GO:0000791 [euchromatin]
GO:0000904 [cell morphogenesis involved in differentiation]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001501 [skeletal system development]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001649 [osteoblast differentiation]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001701 [in utero embryonic development]
GO:0001702 [gastrulation with mouth forming second]
GO:0001706 [endoderm formation]
GO:0001708 [cell fate specification]
GO:0001711 [endodermal cell fate commitment]
GO:0001764 [neuron migration]
GO:0001822 [kidney development]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001840 [neural plate development]
GO:0001894 [tissue homeostasis]
GO:0001944 [vasculature development]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0002062 [chondrocyte differentiation]
GO:0002067 [glandular epithelial cell differentiation]
GO:0002089 [lens morphogenesis in camera-type eye]
GO:0003266 [regulation of secondary heart field cardioblast proliferation]
GO:0003338 [metanephros morphogenesis]
GO:0003340 [negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005916 [fascia adherens]
GO:0005923 [bicellular tight junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006351 [DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006366 [transcription by RNA polymerase II]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007268 [chemical synaptic transmission]
GO:0007398 [ectoderm development]
GO:0007399 [nervous system development]
GO:0007403 [glial cell fate determination]
GO:0007405 [neuroblast proliferation]
GO:0007507 [heart development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008104 [protein localization]
GO:0008283 [cell population proliferation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009410 [response to xenobiotic stimulus]
GO:0009948 [anterior/posterior axis specification]
GO:0009950 [dorsal/ventral axis specification]
GO:0009953 [dorsal/ventral pattern formation]
GO:0009954 [proximal/distal pattern formation]
GO:0010463 [mesenchymal cell proliferation]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0014704 [intercalated disc]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016327 [apicolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016600 [flotillin complex]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0021819 [layer formation in cerebral cortex]
GO:0021854 [hypothalamus development]
GO:0022009 [central nervous system vasculogenesis]
GO:0022405 [hair cycle process]
GO:0030018 [Z disc]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030097 [hemopoiesis]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030217 [T cell differentiation]
GO:0030316 [osteoclast differentiation]
GO:0030324 [lung development]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030539 [male genitalia development]
GO:0030856 [regulation of epithelial cell differentiation]
GO:0030858 [positive regulation of epithelial cell differentiation]
GO:0030877 [beta-catenin destruction complex]
GO:0030900 [forebrain development]
GO:0030901 [midbrain development]
GO:0030902 [hindbrain development]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0031016 [pancreas development]
GO:0031069 [hair follicle morphogenesis]
GO:0031253 [cell projection membrane]
GO:0031528 [microvillus membrane]
GO:0031641 [regulation of myelination]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032331 [negative regulation of chondrocyte differentiation]
GO:0032355 [response to estradiol]
GO:0032968 [positive regulation of transcription elongation by RNA polymerase II]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033077 [T cell differentiation in thymus]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034332 [adherens junction organization]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0034750 [Scrib-APC-beta-catenin complex]
GO:0035050 [embryonic heart tube development]
GO:0035112 [genitalia morphogenesis]
GO:0035115 [embryonic forelimb morphogenesis]
GO:0035116 [embryonic hindlimb morphogenesis]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0036520 [astrocyte-dopaminergic neuron signaling]
GO:0042127 [regulation of cell population proliferation]
GO:0042129 [regulation of T cell proliferation]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042733 [embryonic digit morphogenesis]
GO:0042734 [presynaptic membrane]
GO:0042981 [regulation of apoptotic process]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043296 [apical junction complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043588 [skin development]
GO:0044093 [positive regulation of molecular function]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044338 [canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045177 [apical part of cell]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045453 [bone resorption]
GO:0045595 [regulation of cell differentiation]
GO:0045596 [negative regulation of cell differentiation]
GO:0045597 [positive regulation of cell differentiation]
GO:0045603 [positive regulation of endothelial cell differentiation]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045670 [regulation of osteoclast differentiation]
GO:0045671 [negative regulation of osteoclast differentiation]
GO:0045743 [positive regulation of fibroblast growth factor receptor signaling pathway]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048469 [cell maturation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048489 [synaptic vesicle transport]
GO:0048513 [animal organ development]
GO:0048538 [thymus development]
GO:0048568 [embryonic organ development]
GO:0048599 [oocyte development]
GO:0048617 [embryonic foregut morphogenesis]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0048664 [neuron fate determination]
GO:0048709 [oligodendrocyte differentiation]
GO:0048715 [negative regulation of oligodendrocyte differentiation]
GO:0050767 [regulation of neurogenesis]
GO:0050768 [negative regulation of neurogenesis]
GO:0050808 [synapse organization]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051145 [smooth muscle cell differentiation]
GO:0051450 [myoblast proliferation]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051884 [regulation of timing of anagen]
GO:0051963 [regulation of synapse assembly]
GO:0051973 [positive regulation of telomerase activity]
GO:0060066 [oviduct development]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060173 [limb development]
GO:0060439 [trachea morphogenesis]
GO:0060440 [trachea formation]
GO:0060441 [epithelial tube branching involved in lung morphogenesis]
GO:0060479 [lung cell differentiation]
GO:0060484 [lung-associated mesenchyme development]
GO:0060487 [lung epithelial cell differentiation]
GO:0060492 [lung induction]
GO:0060742 [epithelial cell differentiation involved in prostate gland development]
GO:0060767 [epithelial cell proliferation involved in prostate gland development]
GO:0060769 [positive regulation of epithelial cell proliferation involved in prostate gland development]
GO:0060789 [hair follicle placode formation]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0061047 [positive regulation of branching involved in lung morphogenesis]
GO:0061154 [endothelial tube morphogenesis]
GO:0061198 [fungiform papilla formation]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061550 [cranial ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072033 [renal vesicle formation]
GO:0072053 [renal inner medulla development]
GO:0072054 [renal outer medulla development]
GO:0072079 [nephron tubule formation]
GO:0072089 [stem cell proliferation]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090279 [regulation of calcium ion import]
GO:0090425 [acinar cell differentiation]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0097091 [synaptic vesicle clustering]
GO:0097190 [apoptotic signaling pathway]
GO:0097718 [disordered domain specific binding]
GO:0098609 [cell-cell adhesion]
GO:0098685 [Schaffer collateral - CA1 synapse]
GO:0098831 [presynaptic active zone cytoplasmic component]
GO:0098978 [glutamatergic synapse]
GO:0099092 [postsynaptic density, intracellular component]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901215 [negative regulation of neuron death]
GO:1903204 [negative regulation of oxidative stress-induced neuron death]
GO:1904796 [regulation of core promoter binding]
GO:1904798 [positive regulation of core promoter binding]
GO:1904888 [cranial skeletal system development]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990403 [embryonic brain development]
GO:1990711 [beta-catenin-ICAT complex]
GO:1990791 [dorsal root ganglion development]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
GO:2000017 [positive regulation of determination of dorsal identity]
GO:2000179 [positive regulation of neural precursor cell proliferation]
GO:2000288 [positive regulation of myoblast proliferation]
GO:2000648 [positive regulation of stem cell proliferation]
GO:2001234 [negative regulation of apoptotic signaling pathway]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-202
ENSP00000379486
ENST00000396183
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-203
ENSP00000379488
ENST00000396185
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-204
ENSP00000385604
ENST00000405570
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-205
ENSP00000400508
ENST00000426215
C9IZ65
[Direct mapping] Catenin beta-1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007155 [cell adhesion]
GO:0045296 [cadherin binding]
Show all
 59 aa
6.5 kDa 		No 0
CTNNB1-206
ENSP00000412219
ENST00000431914
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-207
ENSP00000387455
ENST00000433400
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-208
ENSP00000401599
ENST00000441708
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-209
ENSP00000409302
ENST00000450969
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-210
ENSP00000411226
ENST00000453024
B4DGU4
[Direct mapping] Catenin beta-1; cDNA FLJ57878, highly similar to Beta-catenin
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0007155 [cell adhesion]
GO:0045296 [cadherin binding]
GO:0070161 [anchoring junction]
Show all
 774 aa
84.8 kDa 		No 0
CTNNB1-216
ENSP00000495244
ENST00000642248
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-217
ENSP00000495076
ENST00000642315
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-218
ENSP00000495719
ENST00000642426
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-219
ENSP00000496295
ENST00000642836
B4DGU4
[Direct mapping] Catenin beta-1; cDNA FLJ57878, highly similar to Beta-catenin
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0007155 [cell adhesion]
GO:0045296 [cadherin binding]
GO:0070161 [anchoring junction]
Show all
 774 aa
84.8 kDa 		No 0
CTNNB1-220
ENSP00000496020
ENST00000642886
A0A2R8Y750
[Direct mapping] Catenin beta-1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0007155 [cell adhesion]
GO:0045296 [cadherin binding]
GO:0070161 [anchoring junction]
Show all
 744 aa
81.4 kDa 		No 0
CTNNB1-221
ENSP00000494422
ENST00000642986
A0A2R8Y5C3
[Direct mapping] Catenin beta-1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0007155 [cell adhesion]
GO:0045296 [cadherin binding]
GO:0070161 [anchoring junction]
Show all
 737 aa
80.7 kDa 		No 0
CTNNB1-222
ENSP00000496385
ENST00000642992
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-223
ENSP00000495450
ENST00000643031
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-225
ENSP00000494677
ENST00000643297
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-226
ENSP00000494411
ENST00000643541
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-228
ENSP00000494053
ENST00000643977
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-229
ENSP00000493610
ENST00000643992
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-230
ENSP00000496649
ENST00000644138
A0A2R8Y804
[Direct mapping] Catenin beta-1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0007155 [cell adhesion]
GO:0045296 [cadherin binding]
GO:0070161 [anchoring junction]
Show all
 702 aa
77.2 kDa 		No 0
CTNNB1-233
ENSP00000494780
ENST00000644524
B4DGU4
[Direct mapping] Catenin beta-1; cDNA FLJ57878, highly similar to Beta-catenin
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0007155 [cell adhesion]
GO:0045296 [cadherin binding]
GO:0070161 [anchoring junction]
Show all
 774 aa
84.8 kDa 		No 0
CTNNB1-234
ENSP00000495794
ENST00000644678
B4DGU4
[Direct mapping] Catenin beta-1; cDNA FLJ57878, highly similar to Beta-catenin
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0007155 [cell adhesion]
GO:0045296 [cadherin binding]
GO:0070161 [anchoring junction]
Show all
 774 aa
84.8 kDa 		No 0
CTNNB1-235
ENSP00000495992
ENST00000644867
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-236
ENSP00000496511
ENST00000644873
A0A2R8Y7Z0
[Direct mapping] Catenin beta-1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0007155 [cell adhesion]
GO:0045296 [cadherin binding]
GO:0070161 [anchoring junction]
Show all
 780 aa
85.4 kDa 		No 0
CTNNB1-237
ENSP00000496584
ENST00000644906
A0A2R8Y815
[Direct mapping] Catenin beta-1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0007155 [cell adhesion]
GO:0045296 [cadherin binding]
GO:0070161 [anchoring junction]
Show all
 186 aa
20.4 kDa 		No 0
CTNNB1-238
ENSP00000496180
ENST00000645210
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-239
ENSP00000494654
ENST00000645276
A0A2R8Y5A3
[Direct mapping] Catenin beta-1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0007155 [cell adhesion]
GO:0045296 [cadherin binding]
GO:0070161 [anchoring junction]
Show all
 783 aa
85.7 kDa 		No 0
CTNNB1-241
ENSP00000495360
ENST00000645320
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-242
ENSP00000494467
ENST00000645493
B4DGU4
[Direct mapping] Catenin beta-1; cDNA FLJ57878, highly similar to Beta-catenin
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0007155 [cell adhesion]
GO:0045296 [cadherin binding]
GO:0070161 [anchoring junction]
Show all
 774 aa
84.8 kDa 		No 0
CTNNB1-244
ENSP00000495286
ENST00000645900
B4DGU4
[Direct mapping] Catenin beta-1; cDNA FLJ57878, highly similar to Beta-catenin
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0007155 [cell adhesion]
GO:0045296 [cadherin binding]
GO:0070161 [anchoring junction]
Show all
 774 aa
84.8 kDa 		No 0
CTNNB1-245
ENSP00000495287
ENST00000645927
A0A2R8Y6G0
[Direct mapping] Catenin beta-1
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0007155 [cell adhesion]
GO:0045296 [cadherin binding]
GO:0070161 [anchoring junction]
Show all
 367 aa
40.1 kDa 		No 0
CTNNB1-246
ENSP00000494845
ENST00000645982
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-248
ENSP00000495426
ENST00000646116
B4DGU4
[Direct mapping] Catenin beta-1; cDNA FLJ57878, highly similar to Beta-catenin
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0007155 [cell adhesion]
GO:0045296 [cadherin binding]
GO:0070161 [anchoring junction]
Show all
 774 aa
84.8 kDa 		No 0
CTNNB1-249
ENSP00000495161
ENST00000646174
B4DGU4
[Direct mapping] Catenin beta-1; cDNA FLJ57878, highly similar to Beta-catenin
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0007155 [cell adhesion]
GO:0045296 [cadherin binding]
GO:0070161 [anchoring junction]
Show all
 774 aa
84.8 kDa 		No 0
CTNNB1-250
ENSP00000494914
ENST00000646369
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-251
ENSP00000496067
ENST00000646381
B4DGU4
[Direct mapping] Catenin beta-1; cDNA FLJ57878, highly similar to Beta-catenin
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0007155 [cell adhesion]
GO:0045296 [cadherin binding]
GO:0070161 [anchoring junction]
Show all
 774 aa
84.8 kDa 		No 0
CTNNB1-252
ENSP00000496021
ENST00000646725
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-254
ENSP00000494849
ENST00000647264
A0A2R8Y5Z1
[Direct mapping] Catenin beta-1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0007155 [cell adhesion]
GO:0045296 [cadherin binding]
GO:0070161 [anchoring junction]
Show all
 752 aa
82.4 kDa 		No 0
CTNNB1-255
ENSP00000493533
ENST00000647390
P35222
[Direct mapping] Catenin beta-1
Show all
A0A024R2Q3
[Target identity:100%; Query identity:100%] Catenin (Cadherin-associated protein), beta 1, 88kDa, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000791 [euchromatin]
GO:0000922 [spindle pole]
GO:0001221 [transcription coregulator binding]
GO:0001222 [transcription corepressor binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016525 [negative regulation of angiogenesis]
GO:0016922 [nuclear receptor binding]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030877 [beta-catenin destruction complex]
GO:0030997 [regulation of centriole-centriole cohesion]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032355 [response to estradiol]
GO:0032991 [protein-containing complex]
GO:0032993 [protein-DNA complex]
GO:0033234 [negative regulation of protein sumoylation]
GO:0034333 [adherens junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0035315 [hair cell differentiation]
GO:0035995 [detection of muscle stretch]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044325 [transmembrane transporter binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045202 [synapse]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0046332 [SMAD binding]
GO:0048145 [regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0051973 [positive regulation of telomerase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061154 [endothelial tube morphogenesis]
GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation]
GO:0061549 [sympathetic ganglion development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070062 [extracellular exosome]
GO:0070161 [anchoring junction]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0070411 [I-SMAD binding]
GO:0070602 [regulation of centromeric sister chromatid cohesion]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071681 [cellular response to indole-3-methanol]
GO:0071944 [cell periphery]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072497 [mesenchymal stem cell differentiation]
GO:0090279 [regulation of calcium ion import]
GO:0098609 [cell-cell adhesion]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990226 [histone methyltransferase binding]
GO:1990907 [beta-catenin-TCF complex]
GO:1990909 [Wnt signalosome]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 781 aa
85.5 kDa 		No 0
CTNNB1-256
ENSP00000493583
ENST00000647413
A0A2R8YCH5
[Direct mapping] Catenin beta-1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of the urinary system
   Cancers of eye, brain, and central nervous system
   Cancers of endocrine organs
   Nervous system diseases
   Eye disease
   Skin diseases
   Skin and soft tissue diseases
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0007155 [cell adhesion]
GO:0045296 [cadherin binding]
GO:0070161 [anchoring junction]
Show all
 779 aa
85.3 kDa 		No 0

Contact

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The Human Protein Atlas

The Human Protein Atlas project is funded
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contact@proteinatlas.org