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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
p12.2
Chromosome location (bp)
22321099 - 22331484
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility 1,2,3,4,5,6,7. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A 8,9. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 10,11,12....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chromatin regulator, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P35226 [Direct mapping] Polycomb complex protein BMI-1
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Human disease related genes Cancers Cancers of male genital organs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000151[ubiquitin ligase complex] GO:0000792[heterochromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001501[skeletal system development] GO:0001701[in utero embryonic development] GO:0003682[chromatin binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006306[DNA methylation] GO:0006325[chromatin organization] GO:0006959[humoral immune response] GO:0007379[segment specification] GO:0007420[brain development] GO:0008270[zinc ion binding] GO:0010468[regulation of gene expression] GO:0016573[histone acetylation] GO:0016574[histone ubiquitination] GO:0016604[nuclear body] GO:0021903[rostrocaudal neural tube patterning] GO:0030097[hemopoiesis] GO:0030890[positive regulation of B cell proliferation] GO:0031519[PcG protein complex] GO:0033092[positive regulation of immature T cell proliferation in thymus] GO:0035102[PRC1 complex] GO:0036353[histone H2A-K119 monoubiquitination] GO:0043565[sequence-specific DNA binding] GO:0045814[negative regulation of gene expression, epigenetic] GO:0046872[metal ion binding] GO:0048103[somatic stem cell division] GO:0048146[positive regulation of fibroblast proliferation] GO:0048704[embryonic skeletal system morphogenesis] GO:0048706[embryonic skeletal system development] GO:0051443[positive regulation of ubiquitin-protein transferase activity] GO:0071347[cellular response to interleukin-1] GO:0071535[RING-like zinc finger domain binding] GO:0071549[cellular response to dexamethasone stimulus] GO:0097027[ubiquitin-protein transferase activator activity] GO:0097190[apoptotic signaling pathway] GO:1990841[promoter-specific chromatin binding] GO:2000011[regulation of adaxial/abaxial pattern formation] GO:2001234[negative regulation of apoptotic signaling pathway]
Q5T8Z6 [Direct mapping] Polycomb complex protein BMI-1
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of male genital organs Protein evidence (Ezkurdia et al 2014)
Q5T8Z4 [Direct mapping] Polycomb complex protein BMI-1
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of male genital organs Protein evidence (Ezkurdia et al 2014)
Q5T8Z2 [Direct mapping] Polycomb complex protein BMI-1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of male genital organs Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
