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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q24.1
Chromosome location (bp)
65528563 - 65561648
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Wnt signaling pathway
Gene summary (Entrez)i
Useful information about the gene from Entrez
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Cancers Cancers of the digestive system Cancers of eye, brain, and central nervous system Digestive system diseases Mouth and dental diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001649[osteoblast differentiation] GO:0001756[somitogenesis] GO:0001934[positive regulation of protein phosphorylation] GO:0001957[intramembranous ossification] GO:0003139[secondary heart field specification] GO:0003180[aortic valve morphogenesis] GO:0003183[mitral valve morphogenesis] GO:0003413[chondrocyte differentiation involved in endochondral bone morphogenesis] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0008013[beta-catenin binding] GO:0008104[protein localization] GO:0008219[cell death] GO:0008283[cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0010942[positive regulation of cell death] GO:0016055[Wnt signaling pathway] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0030111[regulation of Wnt signaling pathway] GO:0030282[bone mineralization] GO:0030877[beta-catenin destruction complex] GO:0031625[ubiquitin protein ligase binding] GO:0032423[regulation of mismatch repair] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032991[protein-containing complex] GO:0033687[osteoblast proliferation] GO:0033689[negative regulation of osteoblast proliferation] GO:0042476[odontogenesis] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043570[maintenance of DNA repeat elements] GO:0045600[positive regulation of fat cell differentiation] GO:0045668[negative regulation of osteoblast differentiation] GO:0045860[positive regulation of protein kinase activity] GO:0048255[mRNA stabilization] GO:0048468[cell development] GO:0048545[response to steroid hormone] GO:0060090[molecular adaptor activity] GO:0061181[regulation of chondrocyte development] GO:0070411[I-SMAD binding] GO:0070602[regulation of centromeric sister chromatid cohesion] GO:0071407[cellular response to organic cyclic compound] GO:0071549[cellular response to dexamethasone stimulus] GO:0072089[stem cell proliferation] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:1903053[regulation of extracellular matrix organization] GO:2000054[negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification]
Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of eye, brain, and central nervous system Digestive system diseases Mouth and dental diseases Protein evidence (Ezkurdia et al 2014)
Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of eye, brain, and central nervous system Digestive system diseases Mouth and dental diseases Protein evidence (Ezkurdia et al 2014)
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GO:0005737[cytoplasm] GO:0090090[negative regulation of canonical Wnt signaling pathway]
Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of eye, brain, and central nervous system Digestive system diseases Mouth and dental diseases Protein evidence (Ezkurdia et al 2014)
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GO:0005737[cytoplasm] GO:0090090[negative regulation of canonical Wnt signaling pathway]
Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of eye, brain, and central nervous system Digestive system diseases Mouth and dental diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737[cytoplasm] GO:0090090[negative regulation of canonical Wnt signaling pathway]
Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of eye, brain, and central nervous system Digestive system diseases Mouth and dental diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737[cytoplasm] GO:0090090[negative regulation of canonical Wnt signaling pathway]
Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of eye, brain, and central nervous system Digestive system diseases Mouth and dental diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
