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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Low density lipoprotein receptor class A domain containing 4
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
18
Cytoband
p11.21
Chromosome location (bp)
13217498 - 13652755
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Signal transduction inhibitor
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables R-SMAD binding activity. Involved in negative regulation of cell migration; negative regulation of epithelial to mesenchymal transition; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Located in early endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O15165 [Direct mapping] Low-density lipoprotein receptor class A domain-containing protein 4
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level DeepTMHMM predicted membrane proteins
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GO:0000139[Golgi membrane] GO:0005768[endosome] GO:0009968[negative regulation of signal transduction] GO:0010719[negative regulation of epithelial to mesenchymal transition] GO:0010991[negative regulation of SMAD protein complex assembly] GO:0016020[membrane] GO:0030336[negative regulation of cell migration] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0031901[early endosome membrane] GO:0043231[intracellular membrane-bounded organelle] GO:0060394[negative regulation of pathway-restricted SMAD protein phosphorylation] GO:0070412[R-SMAD binding]
O15165 [Direct mapping] Low-density lipoprotein receptor class A domain-containing protein 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level DeepTMHMM predicted membrane proteins
Show all
GO:0000139[Golgi membrane] GO:0005768[endosome] GO:0009968[negative regulation of signal transduction] GO:0010719[negative regulation of epithelial to mesenchymal transition] GO:0010991[negative regulation of SMAD protein complex assembly] GO:0016020[membrane] GO:0030336[negative regulation of cell migration] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0031901[early endosome membrane] GO:0043231[intracellular membrane-bounded organelle] GO:0060394[negative regulation of pathway-restricted SMAD protein phosphorylation] GO:0070412[R-SMAD binding]
O15165 [Direct mapping] Low-density lipoprotein receptor class A domain-containing protein 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level DeepTMHMM predicted membrane proteins
Show all
GO:0000139[Golgi membrane] GO:0005768[endosome] GO:0009968[negative regulation of signal transduction] GO:0010719[negative regulation of epithelial to mesenchymal transition] GO:0010991[negative regulation of SMAD protein complex assembly] GO:0016020[membrane] GO:0030336[negative regulation of cell migration] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0031901[early endosome membrane] GO:0043231[intracellular membrane-bounded organelle] GO:0060394[negative regulation of pathway-restricted SMAD protein phosphorylation] GO:0070412[R-SMAD binding]
The Human Protein Atlas project is funded
