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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
q24
Chromosome location (bp)
105894775 - 106004027
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell adhesion, Differentiation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium
Gene summary (Entrez)i
Useful information about the gene from Entrez
Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell-cell adhesion mediated by integrin; positive regulation of ERK1 and ERK2 cascade; and positive regulation of osteoblast differentiation. Predicted to act upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway. Located in extracellular exosome. Part of collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001657[ureteric bud development] GO:0001658[branching involved in ureteric bud morphogenesis] GO:0005178[integrin binding] GO:0005201[extracellular matrix structural constituent] GO:0005509[calcium ion binding] GO:0005576[extracellular region] GO:0005604[basement membrane] GO:0007155[cell adhesion] GO:0007160[cell-matrix adhesion] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0010694[positive regulation of alkaline phosphatase activity] GO:0010811[positive regulation of cell-substrate adhesion] GO:0016020[membrane] GO:0030154[cell differentiation] GO:0030198[extracellular matrix organization] GO:0030485[smooth muscle contractile fiber] GO:0030511[positive regulation of transforming growth factor beta receptor signaling pathway] GO:0031012[extracellular matrix] GO:0033631[cell-cell adhesion mediated by integrin] GO:0045184[establishment of protein localization] GO:0045669[positive regulation of osteoblast differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0045987[positive regulation of smooth muscle contraction] GO:0051145[smooth muscle cell differentiation] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071356[cellular response to tumor necrosis factor] GO:0097195[pilomotor reflex]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001657[ureteric bud development] GO:0001658[branching involved in ureteric bud morphogenesis] GO:0005178[integrin binding] GO:0005201[extracellular matrix structural constituent] GO:0005509[calcium ion binding] GO:0005576[extracellular region] GO:0007155[cell adhesion] GO:0007160[cell-matrix adhesion] GO:0010811[positive regulation of cell-substrate adhesion] GO:0016020[membrane] GO:0030154[cell differentiation] GO:0030198[extracellular matrix organization] GO:0033631[cell-cell adhesion mediated by integrin] GO:0045669[positive regulation of osteoblast differentiation] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071356[cellular response to tumor necrosis factor]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001657[ureteric bud development] GO:0001658[branching involved in ureteric bud morphogenesis] GO:0005178[integrin binding] GO:0005201[extracellular matrix structural constituent] GO:0005509[calcium ion binding] GO:0005576[extracellular region] GO:0007155[cell adhesion] GO:0007160[cell-matrix adhesion] GO:0010811[positive regulation of cell-substrate adhesion] GO:0016020[membrane] GO:0030154[cell differentiation] GO:0030198[extracellular matrix organization] GO:0033631[cell-cell adhesion mediated by integrin] GO:0045669[positive regulation of osteoblast differentiation] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071356[cellular response to tumor necrosis factor]
SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
