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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q37.1
Chromosome location (bp)
233059967 - 233207903
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways 1,2,3. Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate 4,5,6. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity 7. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, Immunity, Lipid metabolism
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Deficiencies in the encoded protein, SHIP1, have been associated with Inflammatory Bowel Disease types such as Crohn's Disease and Ulcerative Colitis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2020]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002376[immune system process] GO:0003824[catalytic activity] GO:0004439[phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity] GO:0004445[inositol-polyphosphate 5-phosphatase activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006629[lipid metabolic process] GO:0006661[phosphatidylinositol biosynthetic process] GO:0006796[phosphate-containing compound metabolic process] GO:0006915[apoptotic process] GO:0007165[signal transduction] GO:0009966[regulation of signal transduction] GO:0009968[negative regulation of signal transduction] GO:0016020[membrane] GO:0016314[phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0017124[SH3 domain binding] GO:0019637[organophosphate metabolic process] GO:0034485[phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity] GO:0045121[membrane raft] GO:0045579[positive regulation of B cell differentiation] GO:0045659[negative regulation of neutrophil differentiation] GO:0045779[negative regulation of bone resorption] GO:0046856[phosphatidylinositol dephosphorylation] GO:0050776[regulation of immune response] GO:0050852[T cell receptor signaling pathway] GO:0052658[inositol-1,4,5-trisphosphate 5-phosphatase activity] GO:0052659[inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity]
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002376[immune system process] GO:0003824[catalytic activity] GO:0004439[phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity] GO:0004445[inositol-polyphosphate 5-phosphatase activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006629[lipid metabolic process] GO:0006661[phosphatidylinositol biosynthetic process] GO:0006796[phosphate-containing compound metabolic process] GO:0006915[apoptotic process] GO:0007165[signal transduction] GO:0008340[determination of adult lifespan] GO:0009966[regulation of signal transduction] GO:0009968[negative regulation of signal transduction] GO:0016020[membrane] GO:0016064[immunoglobulin mediated immune response] GO:0016314[phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0017124[SH3 domain binding] GO:0019637[organophosphate metabolic process] GO:0030853[negative regulation of granulocyte differentiation] GO:0030889[negative regulation of B cell proliferation] GO:0032715[negative regulation of interleukin-6 production] GO:0034485[phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity] GO:0035556[intracellular signal transduction] GO:0043065[positive regulation of apoptotic process] GO:0045121[membrane raft] GO:0045579[positive regulation of B cell differentiation] GO:0045621[positive regulation of lymphocyte differentiation] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045656[negative regulation of monocyte differentiation] GO:0045659[negative regulation of neutrophil differentiation] GO:0045671[negative regulation of osteoclast differentiation] GO:0045779[negative regulation of bone resorption] GO:0046856[phosphatidylinositol dephosphorylation] GO:0050776[regulation of immune response] GO:0050777[negative regulation of immune response] GO:0050852[T cell receptor signaling pathway] GO:0050869[negative regulation of B cell activation] GO:0052658[inositol-1,4,5-trisphosphate 5-phosphatase activity] GO:0052659[inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity]
The Human Protein Atlas project is funded
