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STXBP6
HPA
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  • STXBP6
PROTEIN SUMMARY GENE INFORMATION RNA DATA ANTIBODY DATA
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

STXBP6
Synonyms amisyn, HSPC156
Gene descriptioni

Full gene name according to HGNC.

Syntaxin binding protein 6
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 14
Cytoband q12
Chromosome location (bp) 24809454 - 25050147
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

6
Ensembl ENSG00000168952 (version 109)
Entrez gene 29091
HGNC HGNC:19666
UniProt Q8NFX7 (UniProt - Evidence at protein level)
neXtProt NX_Q8NFX7
GeneCards STXBP6
Antibodypedia STXBP6 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i

Useful information about the protein provided by UniProt.

Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.... show less
Gene summary (Entrez)i

Useful information about the gene from Entrez

STXBP6 binds components of the SNARE complex (see MIM 603215) and may be involved in regulating SNARE complex formation (Scales et al., 2002).[supplied by OMIM, Mar 2008]... show less
PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
STXBP6-201
ENSP00000324302
ENST00000323944
Q8NFX7
[Direct mapping] Syntaxin-binding protein 6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006887 [exocytosis]
GO:0006893 [Golgi to plasma membrane transport]
GO:0016020 [membrane]
GO:0035493 [SNARE complex assembly]
GO:0035542 [regulation of SNARE complex assembly]
GO:0045920 [negative regulation of exocytosis]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
Show all
210 aa
23.6 kDa
No 0
STXBP6-202
ENSP00000379928
ENST00000396700
Q8NFX7
[Direct mapping] Syntaxin-binding protein 6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006887 [exocytosis]
GO:0006893 [Golgi to plasma membrane transport]
GO:0016020 [membrane]
GO:0035493 [SNARE complex assembly]
GO:0035542 [regulation of SNARE complex assembly]
GO:0045920 [negative regulation of exocytosis]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
Show all
210 aa
23.6 kDa
No 0
STXBP6-203
ENSP00000397212
ENST00000419632
Q8NFX7
[Direct mapping] Syntaxin-binding protein 6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006887 [exocytosis]
GO:0006893 [Golgi to plasma membrane transport]
GO:0016020 [membrane]
GO:0035493 [SNARE complex assembly]
GO:0035542 [regulation of SNARE complex assembly]
GO:0045920 [negative regulation of exocytosis]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
Show all
210 aa
23.6 kDa
No 0
STXBP6-204
ENSP00000449536
ENST00000546511
Q8NFX7
[Direct mapping] Syntaxin-binding protein 6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006887 [exocytosis]
GO:0006893 [Golgi to plasma membrane transport]
GO:0016020 [membrane]
GO:0035493 [SNARE complex assembly]
GO:0035542 [regulation of SNARE complex assembly]
GO:0045920 [negative regulation of exocytosis]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
Show all
210 aa
23.6 kDa
No 0
STXBP6-206
ENSP00000447655
ENST00000548369
Q8NFX7
[Direct mapping] Syntaxin-binding protein 6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006887 [exocytosis]
GO:0006893 [Golgi to plasma membrane transport]
GO:0016020 [membrane]
GO:0035493 [SNARE complex assembly]
GO:0035542 [regulation of SNARE complex assembly]
GO:0045920 [negative regulation of exocytosis]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
Show all
108 aa
11.6 kDa
No 0
STXBP6-207
ENSP00000449379
ENST00000550887
Q8NFX7
[Direct mapping] Syntaxin-binding protein 6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006887 [exocytosis]
GO:0006893 [Golgi to plasma membrane transport]
GO:0016020 [membrane]
GO:0035493 [SNARE complex assembly]
GO:0035542 [regulation of SNARE complex assembly]
GO:0045920 [negative regulation of exocytosis]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
Show all
210 aa
23.6 kDa
No 0

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