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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q11.2
Chromosome location (bp)
27629798 - 27649560
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Binds galactosides bmed/18005988">1. Has high affinity for the Forssman pentasaccharide 2. Ligand for HAVCR2/TIM3 3. Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death 4. Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration 5. Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation 6. Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection 7. Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells 8,9. Inhibits degranulation and induces apoptosis of mast cells 10. Induces maturation and migration of dendritic cells 11,12. Inhibits natural killer (NK) cell function 13. Can transform NK cell phenotype from peripheral to decidual during pregnancy 14. Astrocyte derived galectin-9 enhances microglial TNF production (By similarity). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (By similarity). Highly selective to the anion urate (By similarity)....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Chemotaxis, Immunity
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Lectin
Gene summary (Entrez)i
Useful information about the gene from Entrez
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002376[immune system process] GO:0002519[natural killer cell tolerance induction] GO:0005515[protein binding] GO:0005534[galactose binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006935[chemotaxis] GO:0006954[inflammatory response] GO:0007565[female pregnancy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016936[galactoside binding] GO:0019899[enzyme binding] GO:0030246[carbohydrate binding] GO:0032496[response to lipopolysaccharide] GO:0032682[negative regulation of chemokine production] GO:0032689[negative regulation of interferon-gamma production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032729[positive regulation of interferon-gamma production] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032733[positive regulation of interleukin-10 production] GO:0032735[positive regulation of interleukin-12 production] GO:0032736[positive regulation of interleukin-13 production] GO:0032753[positive regulation of interleukin-4 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032834[positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response] GO:0038066[p38MAPK cascade] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043305[negative regulation of mast cell degranulation] GO:0045953[negative regulation of natural killer cell mediated cytotoxicity] GO:0046007[negative regulation of activated T cell proliferation] GO:0046598[positive regulation of viral entry into host cell] GO:0048030[disaccharide binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060135[maternal process involved in female pregnancy] GO:0062023[collagen-containing extracellular matrix] GO:0070241[positive regulation of activated T cell autonomous cell death] GO:0070371[ERK1 and ERK2 cascade] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070555[response to interleukin-1] GO:0071346[cellular response to interferon-gamma] GO:0071636[positive regulation of transforming growth factor beta production] GO:0071639[positive regulation of monocyte chemotactic protein-1 production] GO:0098586[cellular response to virus] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:2000510[positive regulation of dendritic cell chemotaxis] GO:2000562[negative regulation of CD4-positive, alpha-beta T cell proliferation] GO:2000563[positive regulation of CD4-positive, alpha-beta T cell proliferation] GO:2000670[positive regulation of dendritic cell apoptotic process] GO:2001190[positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell] GO:2001200[positive regulation of dendritic cell differentiation] GO:2001269[positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376[immune system process] GO:0002519[natural killer cell tolerance induction] GO:0005534[galactose binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006935[chemotaxis] GO:0006954[inflammatory response] GO:0007565[female pregnancy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016936[galactoside binding] GO:0019899[enzyme binding] GO:0030246[carbohydrate binding] GO:0032496[response to lipopolysaccharide] GO:0032682[negative regulation of chemokine production] GO:0032689[negative regulation of interferon-gamma production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032729[positive regulation of interferon-gamma production] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032733[positive regulation of interleukin-10 production] GO:0032735[positive regulation of interleukin-12 production] GO:0032736[positive regulation of interleukin-13 production] GO:0032753[positive regulation of interleukin-4 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032834[positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response] GO:0038066[p38MAPK cascade] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043305[negative regulation of mast cell degranulation] GO:0045953[negative regulation of natural killer cell mediated cytotoxicity] GO:0046007[negative regulation of activated T cell proliferation] GO:0046598[positive regulation of viral entry into host cell] GO:0048030[disaccharide binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060135[maternal process involved in female pregnancy] GO:0062023[collagen-containing extracellular matrix] GO:0070241[positive regulation of activated T cell autonomous cell death] GO:0070371[ERK1 and ERK2 cascade] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070555[response to interleukin-1] GO:0071346[cellular response to interferon-gamma] GO:0071636[positive regulation of transforming growth factor beta production] GO:0071639[positive regulation of monocyte chemotactic protein-1 production] GO:0098586[cellular response to virus] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:2000510[positive regulation of dendritic cell chemotaxis] GO:2000562[negative regulation of CD4-positive, alpha-beta T cell proliferation] GO:2000563[positive regulation of CD4-positive, alpha-beta T cell proliferation] GO:2000670[positive regulation of dendritic cell apoptotic process] GO:2001190[positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell] GO:2001200[positive regulation of dendritic cell differentiation] GO:2001269[positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376[immune system process] GO:0002519[natural killer cell tolerance induction] GO:0005534[galactose binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006935[chemotaxis] GO:0006954[inflammatory response] GO:0007565[female pregnancy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016936[galactoside binding] GO:0019899[enzyme binding] GO:0030246[carbohydrate binding] GO:0032496[response to lipopolysaccharide] GO:0032682[negative regulation of chemokine production] GO:0032689[negative regulation of interferon-gamma production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032729[positive regulation of interferon-gamma production] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032733[positive regulation of interleukin-10 production] GO:0032735[positive regulation of interleukin-12 production] GO:0032736[positive regulation of interleukin-13 production] GO:0032753[positive regulation of interleukin-4 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032834[positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response] GO:0038066[p38MAPK cascade] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043305[negative regulation of mast cell degranulation] GO:0045953[negative regulation of natural killer cell mediated cytotoxicity] GO:0046007[negative regulation of activated T cell proliferation] GO:0046598[positive regulation of viral entry into host cell] GO:0048030[disaccharide binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060135[maternal process involved in female pregnancy] GO:0062023[collagen-containing extracellular matrix] GO:0070241[positive regulation of activated T cell autonomous cell death] GO:0070371[ERK1 and ERK2 cascade] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070555[response to interleukin-1] GO:0071346[cellular response to interferon-gamma] GO:0071636[positive regulation of transforming growth factor beta production] GO:0071639[positive regulation of monocyte chemotactic protein-1 production] GO:0098586[cellular response to virus] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:2000510[positive regulation of dendritic cell chemotaxis] GO:2000562[negative regulation of CD4-positive, alpha-beta T cell proliferation] GO:2000563[positive regulation of CD4-positive, alpha-beta T cell proliferation] GO:2000670[positive regulation of dendritic cell apoptotic process] GO:2001190[positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell] GO:2001200[positive regulation of dendritic cell differentiation] GO:2001269[positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
The Human Protein Atlas project is funded
