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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes FDA approved drug targets Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q31.1
Chromosome location (bp)
132656263 - 132661110
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Cytokine that plays important roles in allergic inflammation and immune response to parasite infection 1,2. Synergizes with IL2 in regulating interferon-gamma synthesis 3. Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells 4,5. Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Functions also on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils 6. Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6 7. Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 8....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Cytokine
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0001774[microglial cell activation] GO:0002639[positive regulation of immunoglobulin production] GO:0005125[cytokine activity] GO:0005126[cytokine receptor binding] GO:0005144[interleukin-13 receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0007165[signal transduction] GO:0009612[response to mechanical stimulus] GO:0009897[external side of plasma membrane] GO:0010155[regulation of proton transport] GO:0010628[positive regulation of gene expression] GO:0030890[positive regulation of B cell proliferation] GO:0032496[response to lipopolysaccharide] GO:0032723[positive regulation of connective tissue growth factor production] GO:0032733[positive regulation of interleukin-10 production] GO:0033861[negative regulation of NAD(P)H oxidase activity] GO:0035094[response to nicotine] GO:0042116[macrophage activation] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0043032[positive regulation of macrophage activation] GO:0043270[positive regulation of ion transport] GO:0043306[positive regulation of mast cell degranulation] GO:0045471[response to ethanol] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050714[positive regulation of protein secretion] GO:0050728[negative regulation of inflammatory response] GO:0051281[positive regulation of release of sequestered calcium ion into cytosol] GO:0071260[cellular response to mechanical stimulus] GO:0071345[cellular response to cytokine stimulus] GO:0071635[negative regulation of transforming growth factor beta production] GO:0120162[positive regulation of cold-induced thermogenesis] GO:1901215[negative regulation of neuron death] GO:1901247[negative regulation of lung ciliated cell differentiation] GO:1901251[positive regulation of lung goblet cell differentiation] GO:1903660[negative regulation of complement-dependent cytotoxicity] GO:2000231[positive regulation of pancreatic stellate cell proliferation] GO:2000352[negative regulation of endothelial cell apoptotic process]
The Human Protein Atlas project is funded
