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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q12.3
Chromosome location (bp)
108533671 - 108687246
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation....show less
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P48059 [Direct mapping] LIM and senescent cell antigen-like-containing domain protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005925[focal adhesion] GO:0008270[zinc ion binding] GO:0010628[positive regulation of gene expression] GO:0010811[positive regulation of cell-substrate adhesion] GO:0016020[membrane] GO:0019901[protein kinase binding] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0043547[positive regulation of GTPase activity] GO:0045184[establishment of protein localization] GO:0045216[cell-cell junction organization] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0051894[positive regulation of focal adhesion assembly] GO:0070161[anchoring junction] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0098609[cell-cell adhesion] GO:0110165[cellular anatomical entity] GO:1900026[positive regulation of substrate adhesion-dependent cell spreading] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:2001046[positive regulation of integrin-mediated signaling pathway]
P48059 [Direct mapping] LIM and senescent cell antigen-like-containing domain protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005925[focal adhesion] GO:0008270[zinc ion binding] GO:0010628[positive regulation of gene expression] GO:0010811[positive regulation of cell-substrate adhesion] GO:0016020[membrane] GO:0019901[protein kinase binding] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0043547[positive regulation of GTPase activity] GO:0045184[establishment of protein localization] GO:0045216[cell-cell junction organization] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0051894[positive regulation of focal adhesion assembly] GO:0070161[anchoring junction] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0098609[cell-cell adhesion] GO:0110165[cellular anatomical entity] GO:1900026[positive regulation of substrate adhesion-dependent cell spreading] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:2001046[positive regulation of integrin-mediated signaling pathway]
P48059 [Direct mapping] LIM and senescent cell antigen-like-containing domain protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005925[focal adhesion] GO:0008270[zinc ion binding] GO:0010628[positive regulation of gene expression] GO:0010811[positive regulation of cell-substrate adhesion] GO:0016020[membrane] GO:0019901[protein kinase binding] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0043547[positive regulation of GTPase activity] GO:0045184[establishment of protein localization] GO:0045216[cell-cell junction organization] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0051894[positive regulation of focal adhesion assembly] GO:0070161[anchoring junction] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0098609[cell-cell adhesion] GO:0110165[cellular anatomical entity] GO:1900026[positive regulation of substrate adhesion-dependent cell spreading] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:2001046[positive regulation of integrin-mediated signaling pathway]
P48059 [Direct mapping] LIM and senescent cell antigen-like-containing domain protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005925[focal adhesion] GO:0008270[zinc ion binding] GO:0010628[positive regulation of gene expression] GO:0010811[positive regulation of cell-substrate adhesion] GO:0016020[membrane] GO:0019901[protein kinase binding] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0043547[positive regulation of GTPase activity] GO:0045184[establishment of protein localization] GO:0045216[cell-cell junction organization] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0051894[positive regulation of focal adhesion assembly] GO:0070161[anchoring junction] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0098609[cell-cell adhesion] GO:0110165[cellular anatomical entity] GO:1900026[positive regulation of substrate adhesion-dependent cell spreading] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:2001046[positive regulation of integrin-mediated signaling pathway]
P48059 [Direct mapping] LIM and senescent cell antigen-like-containing domain protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005925[focal adhesion] GO:0008270[zinc ion binding] GO:0010628[positive regulation of gene expression] GO:0010811[positive regulation of cell-substrate adhesion] GO:0016020[membrane] GO:0019901[protein kinase binding] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0043547[positive regulation of GTPase activity] GO:0045184[establishment of protein localization] GO:0045216[cell-cell junction organization] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0051894[positive regulation of focal adhesion assembly] GO:0070161[anchoring junction] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0098609[cell-cell adhesion] GO:0110165[cellular anatomical entity] GO:1900026[positive regulation of substrate adhesion-dependent cell spreading] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:2001046[positive regulation of integrin-mediated signaling pathway]
P48059 [Direct mapping] LIM and senescent cell antigen-like-containing domain protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005925[focal adhesion] GO:0008270[zinc ion binding] GO:0010628[positive regulation of gene expression] GO:0010811[positive regulation of cell-substrate adhesion] GO:0016020[membrane] GO:0019901[protein kinase binding] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0043547[positive regulation of GTPase activity] GO:0045184[establishment of protein localization] GO:0045216[cell-cell junction organization] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0051894[positive regulation of focal adhesion assembly] GO:0070161[anchoring junction] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0098609[cell-cell adhesion] GO:0110165[cellular anatomical entity] GO:1900026[positive regulation of substrate adhesion-dependent cell spreading] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:2001046[positive regulation of integrin-mediated signaling pathway]
The Human Protein Atlas project is funded
