Expression of KRT8 in urothelial cancer

BLADDER UROTHELIAL CARCINOMA (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

KRT8 is not prognostic in Bladder Urothelial Carcinoma (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 2195.21

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average pTPM

1521.5

Number of samples

169

Samples

Sample	Description	pTPM
TCGA-XF-A9T2-01A	54 years, male, white, stage:Stage III, dead, 575 days	9478.6
TCGA-BT-A2LD-01A	78 years, female, white, stage:Stage IV, dead, 623 days	9073.3
TCGA-XF-A9SX-01A	63 years, female, white, stage:Stage IV, dead, 719 days	6684.8
TCGA-XF-AAN2-01A	73 years, male, white, stage:Stage II, dead, 1869 days	6043.3
TCGA-FD-A5BT-01A	84 years, male, white, stage:Stage III, dead, 328 days	5926.1
TCGA-XF-A9SV-01A	82 years, male, white, stage:Stage IV, dead, 388 days	5361.4
TCGA-2F-A9KW-01A	67 years, female, white, stage:Stage III, dead, 254 days	4985.0
TCGA-DK-A1A3-01A	60 years, male, white, stage:Stage IV, dead, 665 days	4526.6
TCGA-FD-A5BZ-01A	77 years, female, white, stage:Stage IV, dead, 835 days	4498.3
TCGA-DK-A3IU-01A	58 years, male, white, stage:Stage II, dead, 706 days	4262.2
TCGA-4Z-AA81-01A	80 years, male, white, stage:Stage II, dead, 1270 days	3798.2
TCGA-FD-A3SM-01A	70 years, male, white, stage:Stage IV, dead, 547 days	3736.7
TCGA-XF-A9SZ-01A	79 years, male, white, stage:Stage IV, dead, 859 days	3277.4
TCGA-S5-A6DX-01A	83 years, male, white, stage:Stage IV, dead, 56 days	3105.8
TCGA-5N-A9KI-01A	76 years, female, white, stage:Stage III, dead, 76 days	3102.9
TCGA-XF-A9SL-01A	69 years, male, white, stage:Stage IV, dead, 2020 days	2950.5
TCGA-GU-A767-01A	81 years, male, white, stage:Stage IV, dead, 144 days	2932.5
TCGA-GU-AATO-01A	75 years, male, white, stage:Stage IV, dead, 324 days	2900.6
TCGA-XF-A8HH-01A	61 years, female, white, stage:Stage IV, dead, 57 days	2851.3
TCGA-FD-A6TI-01A	73 years, male, white, stage:Stage IV, dead, 294 days	2784.6
TCGA-4Z-AA7S-01A	66 years, male, black or african american, stage:Stage III, dead, 1064 days	2770.6
TCGA-FJ-A3ZE-01A	65 years, male, white, stage:Stage IV, dead, 324 days	2761.9
TCGA-FD-A3SL-01A	60 years, male, white, stage:Stage IV, dead, 712 days	2754.4
TCGA-FJ-A3Z9-01A	72 years, male, white, stage:'--, dead, 385 days	2707.0
TCGA-FD-A3SS-01A	66 years, male, white, stage:Stage IV, dead, 391 days	2700.3
TCGA-ZF-AA5N-01A	62 years, female, white, stage:Stage IV, dead, 168 days	2697.2
TCGA-CF-A9FL-01A	85 years, male, asian, stage:Stage III, dead, 565 days	2635.9
TCGA-FD-A6TH-01A	63 years, male, white, stage:Stage IV, dead, 131 days	2603.5
TCGA-XF-A8HI-01A	57 years, female, white, stage:Stage IV, dead, 544 days	2503.4
TCGA-UY-A78K-01A	60 years, male, white, stage:Stage IV, dead, 536 days	2503.4
TCGA-GV-A40E-01A	75 years, male, white, stage:Stage II, dead, 261 days	2488.1
TCGA-UY-A78N-01A	80 years, male, white, stage:Stage IV, dead, 2641 days	2451.4
TCGA-XF-A9ST-01A	68 years, male, white, stage:Stage III, dead, 128 days	2421.7
TCGA-DK-A2HX-01A	80 years, female, white, stage:Stage IV, dead, 1420 days	2378.1
TCGA-BT-A3PH-01A	76 years, male, white, stage:Stage IV, dead, 142 days	2318.5
TCGA-G2-A2EO-01A	69 years, male, white, stage:Stage III, dead, 1804 days	2298.4
TCGA-GU-A42P-01A	72 years, male, white, stage:Stage IV, dead, 332 days	2196.3
TCGA-FD-A3B6-01A	75 years, male, white, stage:Stage II, dead, 1005 days	2195.2
TCGA-CU-A5W6-01A	70 years, male, white, stage:Stage III, dead, 56 days	2181.5
TCGA-DK-A1A5-01A	79 years, male, white, stage:Stage II, dead, 65 days	2099.5
TCGA-DK-A3IN-01A	72 years, male, white, stage:Stage III, dead, 250 days	2088.7
TCGA-XF-AAMH-01A	80 years, male, white, stage:Stage IV, dead, 344 days	2009.8
TCGA-CU-A0YR-01A	83 years, male, white, stage:Stage IV, dead, 460 days	1995.4
TCGA-FD-A3SR-01A	68 years, male, white, stage:Stage IV, dead, 602 days	1990.0
TCGA-DK-AA75-01A	82 years, male, white, stage:Stage III, dead, 340 days	1971.7
TCGA-BT-A20P-01A	81 years, female, white, stage:Stage III, dead, 544 days	1909.6
TCGA-BT-A20W-01A	71 years, male, white, stage:Stage II, dead, 254 days	1897.4
TCGA-XF-AAN1-01A	75 years, female, stage:Stage III, dead, 941 days	1883.0
TCGA-XF-A8HC-01A	79 years, male, asian, stage:Stage IV, dead, 200 days	1859.5
TCGA-FD-A62O-01A	74 years, male, white, stage:Stage IV, dead, 216 days	1858.0
TCGA-FD-A5C0-01A	61 years, male, white, stage:Stage IV, dead, 550 days	1834.8
TCGA-GV-A3QF-01A	79 years, male, white, stage:Stage IV, dead, 617 days	1829.5
TCGA-FD-A6TF-01A	80 years, female, white, stage:Stage IV, dead, 69 days	1814.5
TCGA-ZF-AA4U-01A	70 years, male, white, stage:Stage III, dead, 262 days	1780.5
TCGA-CF-A47T-01A	58 years, female, asian, stage:Stage II, dead, 385 days	1776.5
TCGA-XF-A9SJ-01A	83 years, male, white, stage:Stage IV, dead, 98 days	1707.8
TCGA-BL-A3JM-01A	62 years, male, white, stage:Stage III, dead, 205 days	1698.7
TCGA-XF-A8HF-01A	80 years, male, white, stage:Stage III, dead, 2954 days	1695.5
TCGA-XF-AAML-01A	75 years, male, white, stage:Stage II, dead, 232 days	1638.3
TCGA-2F-A9KP-01A	66 years, male, white, stage:Stage IV, dead, 364 days	1627.2
TCGA-BT-A2LB-01A	73 years, female, white, stage:Stage III, dead, 492 days	1561.9
TCGA-XF-AAMZ-01A	81 years, female, white, stage:Stage IV, dead, 1348 days	1547.1
TCGA-E7-A4XJ-01A	66 years, male, asian, stage:Stage II, dead, 68 days	1545.0
TCGA-DK-A3IL-01A	79 years, female, white, stage:Stage IV, dead, 413 days	1543.6
TCGA-DK-A3IK-01A	87 years, male, white, stage:Stage IV, dead, 146 days	1536.2
TCGA-XF-A9SU-01A	74 years, female, white, stage:Stage IV, dead, 182 days	1492.2
TCGA-ZF-A9R0-01A	82 years, male, white, stage:Stage III, dead, 680 days	1448.1
TCGA-GU-A42R-01A	68 years, male, white, stage:Stage IV, dead, 577 days	1440.1
TCGA-4Z-AA80-01A	73 years, male, white, stage:Stage II, dead, 19 days	1438.5
TCGA-BT-A20V-01A	59 years, female, black or african american, stage:Stage IV, dead, 154 days	1426.4
TCGA-GV-A3QH-01A	67 years, male, white, stage:Stage II, dead, 258 days	1415.7
TCGA-ZF-AA4T-01A	65 years, male, white, stage:Stage IV, dead, 599 days	1398.1
TCGA-E7-A541-01A	66 years, male, white, stage:Stage II, dead, 778 days	1394.1
TCGA-2F-A9KO-01A	63 years, male, white, stage:Stage IV, dead, 734 days	1391.8
TCGA-E7-A3X6-01A	70 years, male, white, stage:Stage II, dead, 904 days	1359.3
TCGA-XF-AAMT-01A	75 years, female, white, stage:Stage IV, dead, 90 days	1346.8
TCGA-ZF-AA52-01A	70 years, male, white, stage:Stage III, dead, 1077 days	1326.2
TCGA-E7-A97P-01A	73 years, male, asian, stage:Stage II, dead, 437 days	1318.2
TCGA-XF-AAMX-01A	87 years, female, black or african american, stage:Stage III, dead, 206 days	1317.1
TCGA-ZF-A9RN-01A	67 years, female, white, stage:Stage III, dead, 615 days	1260.1
TCGA-FD-A62P-01A	76 years, male, white, stage:Stage II, dead, 191 days	1256.3
TCGA-GV-A3JV-01A	66 years, male, white, stage:Stage IV, dead, 434 days	1234.8
TCGA-FD-A5BV-01A	47 years, female, white, stage:Stage III, dead, 163 days	1210.6
TCGA-BT-A20T-01A	63 years, male, white, stage:Stage IV, dead, 453 days	1205.9
TCGA-BT-A20Q-01A	73 years, male, white, stage:Stage IV, dead, 593 days	1198.8
TCGA-GC-A3BM-01A	70 years, male, white, stage:Stage II, dead, 651 days	1187.4
TCGA-FD-A6TD-01A	77 years, male, white, stage:Stage III, dead, 386 days	1161.7
TCGA-G2-A3IE-01A	51 years, male, white, stage:Stage II, dead, 612 days	1077.7
TCGA-C4-A0F7-01A	77 years, male, stage:Stage IV, dead, 62 days	1074.5
TCGA-5N-A9KM-01A	73 years, female, white, stage:Stage III, dead, 530 days	1061.0
TCGA-GU-AATQ-01A	68 years, male, white, stage:Stage III, dead, 213 days	1049.9
TCGA-ZF-A9R3-01A	53 years, female, white, stage:Stage II, dead, 949 days	957.3
TCGA-HQ-A5NE-01A	57 years, male, stage:Stage III, dead, 370 days	953.2
TCGA-4Z-AA7N-01A	65 years, male, white, stage:Stage III, dead, 1367 days	941.0
TCGA-BT-A0S7-01A	75 years, male, white, stage:Stage III, dead, 200 days	939.2
TCGA-DK-A3X2-01A	85 years, male, white, stage:Stage IV, dead, 547 days	933.1
TCGA-XF-A9SK-01A	65 years, male, white, stage:Stage IV, dead, 486 days	892.9
TCGA-2F-A9KR-01A	59 years, female, stage:Stage III, dead, 3183 days	882.8
TCGA-CU-A0YO-01A	84 years, male, white, stage:Stage IV, dead, 149 days	874.9
TCGA-DK-A3IQ-01A	74 years, male, white, stage:Stage III, dead, 539 days	865.1
TCGA-BT-A20U-01A	70 years, female, white, stage:Stage III, dead, 455 days	844.4
TCGA-HQ-A5ND-01A	78 years, male, stage:Stage IV, dead, 274 days	841.1
TCGA-GU-A762-01A	87 years, male, white, stage:Stage IV, dead, 232 days	801.2
TCGA-SY-A9G0-01A	82 years, male, white, stage:Stage IV, dead, 1008 days	801.1
TCGA-UY-A78M-01A	81 years, female, asian, stage:Stage IV, dead, 690 days	797.5
TCGA-XF-AAN0-01A	68 years, male, white, stage:Stage IV, dead, 1718 days	796.3
TCGA-DK-AA6L-01A	48 years, male, white, stage:Stage IV, dead, 1163 days	794.3
TCGA-DK-A2I2-01A	63 years, female, white, stage:Stage IV, dead, 237 days	793.2
TCGA-XF-A9SP-01A	59 years, male, white, stage:Stage III, dead, 454 days	791.9
TCGA-4Z-AA86-01A	66 years, male, black or african american, stage:Stage IV, dead, 311 days	791.4
TCGA-G2-A2EC-01A	58 years, female, black or african american, stage:Stage II, dead, 696 days	780.3
TCGA-FD-A3B7-01A	66 years, male, black or african american, stage:Stage III, dead, 122 days	757.1
TCGA-ZF-AA56-01A	79 years, female, white, stage:Stage III, dead, 259 days	751.0
TCGA-C4-A0EZ-01A	69 years, female, stage:Stage IV, dead, 273 days	740.4
TCGA-FD-A6TG-01A	73 years, male, white, stage:Stage IV, dead, 93 days	713.2
TCGA-DK-AA6W-01A	78 years, male, white, stage:Stage II, dead, 415 days	710.5
TCGA-YC-A9TC-01A	71 years, male, white, stage:Stage IV, dead, 20 days	699.3
TCGA-XF-AAMW-01A	79 years, female, white, stage:Stage IV, dead, 253 days	698.5
TCGA-DK-AA6Q-01A	61 years, female, white, stage:Stage IV, dead, 413 days	668.9
TCGA-FD-A3SJ-01A	59 years, male, white, stage:Stage IV, dead, 739 days	658.8
TCGA-ZF-AA4R-01A	67 years, male, white, stage:Stage IV, dead, 1036 days	645.3
TCGA-BT-A20J-01A	75 years, male, white, stage:Stage II, dead, 579 days	628.1
TCGA-BL-A13J-01A	65 years, male, white, stage:Stage IV, dead, 81 days	612.4
TCGA-ZF-A9RE-01A	78 years, female, white, stage:Stage II, dead, 106 days	584.8
TCGA-BT-A3PK-01A	80 years, male, white, stage:Stage II, dead, 303 days	571.8
TCGA-4Z-AA7R-01A	73 years, male, black or african american, stage:Stage IV, dead, 522 days	570.5
TCGA-XF-A9SW-01A	85 years, male, white, stage:Stage IV, dead, 362 days	558.8
TCGA-ZF-A9R9-01A	58 years, male, white, stage:Stage IV, dead, 864 days	550.3
TCGA-4Z-AA82-01A	59 years, male, black or african american, stage:Stage IV, dead, 1556 days	543.3
TCGA-K4-A5RI-01A	67 years, female, white, stage:Stage III, dead, 356 days	510.3
TCGA-G2-A3IB-01A	66 years, male, black or african american, stage:Stage II, dead, 220 days	482.5
TCGA-FD-A3SQ-01A	62 years, male, white, stage:Stage IV, dead, 1423 days	471.8
TCGA-FD-A3B5-01A	86 years, male, black or african american, stage:Stage IV, dead, 272 days	467.4
TCGA-DK-A1AB-01A	74 years, female, white, stage:Stage IV, dead, 508 days	433.7
TCGA-FD-A3N5-01A	69 years, male, black or african american, stage:Stage II, dead, 685 days	430.1
TCGA-BT-A20N-01A	72 years, male, stage:Stage III, dead, 795 days	426.8
TCGA-XF-AAN7-01A	60 years, male, white, stage:Stage IV, dead, 565 days	373.8
TCGA-G2-AA3C-01A	66 years, male, white, stage:Stage IV, dead, 211 days	360.9
TCGA-XF-A8HG-01A	69 years, male, white, stage:Stage III, dead, 467 days	324.1
TCGA-FD-A3B3-01A	74 years, female, white, stage:Stage III, dead, 974 days	313.3
TCGA-G2-A2EL-01A	77 years, male, white, stage:Stage II, dead, 819 days	295.9
TCGA-XF-A9SH-01A	65 years, female, asian, stage:Stage II, dead, 1971 days	275.2
TCGA-CU-A72E-01A	76 years, male, white, stage:Stage IV, dead, 413 days	247.9
TCGA-XF-AAMJ-01A	70 years, male, asian, stage:Stage III, dead, 1670 days	247.8
TCGA-ZF-A9RD-01A	75 years, female, white, stage:Stage IV, dead, 408 days	244.2
TCGA-FD-A43Y-01A	65 years, male, white, stage:Stage III, dead, 474 days	238.5
TCGA-GU-A42Q-01A	67 years, male, white, stage:Stage III, dead, 344 days	232.7
TCGA-K4-A4AC-01A	83 years, male, white, stage:Stage II, dead, 278 days	223.6
TCGA-GC-A3I6-01A	45 years, male, white, stage:Stage III, dead, 630 days	221.2
TCGA-XF-AAN4-01A	77 years, female, white, stage:Stage III, dead, 823 days	183.4
TCGA-FD-A62S-01A	60 years, female, black or african american, stage:Stage III, dead, 406 days	177.1
TCGA-DK-A3IM-01A	76 years, male, white, stage:Stage III, dead, 248 days	157.6
TCGA-XF-AAME-01A	64 years, female, white, stage:Stage II, dead, 2828 days	144.1
TCGA-E5-A4TZ-01A	64 years, male, white, stage:Stage IV, dead, 467 days	130.5
TCGA-BT-A0YX-01A	70 years, female, white, stage:Stage III, dead, 400 days	126.7
TCGA-XF-A9T8-01A	64 years, male, white, stage:Stage III, dead, 418 days	94.2
TCGA-FJ-A871-01A	49 years, male, white, stage:Stage III, dead, 272 days	84.9
TCGA-G2-A2ES-01A	85 years, male, white, stage:Stage II, dead, 1004 days	78.6
TCGA-CU-A0YN-01A	60 years, male, white, stage:Stage III, dead, 393 days	75.7
TCGA-FD-A5BX-01A	82 years, male, white, stage:Stage IV, dead, 173 days	74.3
TCGA-FD-A3B4-01A	55 years, female, black or african american, stage:Stage III, dead, 510 days	58.5
TCGA-4Z-AA7Q-01A	79 years, male, white, stage:Stage III, dead, 510 days	51.2
TCGA-BT-A20X-01A	56 years, male, white, stage:Stage IV, dead, 251 days	34.2
TCGA-XF-AAN8-01A	74 years, female, white, stage:Stage III, dead, 118 days	25.8
TCGA-BL-A13I-01A	57 years, female, white, stage:Stage III, dead, 223 days	17.4
TCGA-ZF-AA54-01A	71 years, male, white, stage:Stage III, dead, 590 days	14.2
TCGA-ZF-AA4N-01A	74 years, male, white, stage:Stage II, dead, 88 days	11.1
TCGA-FD-A3SO-01A	68 years, male, white, stage:Stage IV, dead, 168 days	4.0
TCGA-BT-A20O-01A	75 years, male, white, stage:Stage III, dead, 370 days	0.0
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UROTHELIAL CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.	Antibody HPA049866	Antibody CAB000131	Antibody CAB001696
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Urothelial carcinoma, High grade
Urothelial carcinoma, Low grade
Adenocarcinoma, NOS