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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes CD markers Human disease related genes Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q31.3
Chromosome location (bp)
140631728 - 140633700
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Coreceptor for bacterial lipopolysaccharide 1,2. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) 3,4,5. Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response 6. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway 7. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) 8....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Immunity, Inflammatory response, Innate immunity
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2020]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P08571 [Direct mapping] Monocyte differentiation antigen CD14 Monocyte differentiation antigen CD14, urinary form Monocyte differentiation antigen CD14, membrane-bound form
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CD markers Transporters Accessory Factors Involved in Transport Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Human disease related genes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001530[lipopolysaccharide binding] GO:0001819[positive regulation of cytokine production] GO:0001847[opsonin receptor activity] GO:0001875[lipopolysaccharide immune receptor activity] GO:0002237[response to molecule of bacterial origin] GO:0002376[immune system process] GO:0002752[cell surface pattern recognition receptor signaling pathway] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0006898[receptor-mediated endocytosis] GO:0006909[phagocytosis] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0007166[cell surface receptor signaling pathway] GO:0009408[response to heat] GO:0009617[response to bacterium] GO:0009897[external side of plasma membrane] GO:0009986[cell surface] GO:0010008[endosome membrane] GO:0016019[peptidoglycan immune receptor activity] GO:0016020[membrane] GO:0030667[secretory granule membrane] GO:0031663[lipopolysaccharide-mediated signaling pathway] GO:0031666[positive regulation of lipopolysaccharide-mediated signaling pathway] GO:0032026[response to magnesium ion] GO:0032481[positive regulation of type I interferon production] GO:0032496[response to lipopolysaccharide] GO:0032729[positive regulation of interferon-gamma production] GO:0032757[positive regulation of interleukin-8 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0034142[toll-like receptor 4 signaling pathway] GO:0034145[positive regulation of toll-like receptor 4 signaling pathway] GO:0034612[response to tumor necrosis factor] GO:0045087[innate immune response] GO:0045121[membrane raft] GO:0045471[response to ethanol] GO:0045807[positive regulation of endocytosis] GO:0046696[lipopolysaccharide receptor complex] GO:0051602[response to electrical stimulus] GO:0070062[extracellular exosome] GO:0070891[lipoteichoic acid binding] GO:0071219[cellular response to molecule of bacterial origin] GO:0071222[cellular response to lipopolysaccharide] GO:0071223[cellular response to lipoteichoic acid] GO:0071726[cellular response to diacyl bacterial lipopeptide] GO:0071727[cellular response to triacyl bacterial lipopeptide] GO:1901224[positive regulation of NIK/NF-kappaB signaling]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Human disease related genes Immune system diseases Allergies and autoimmune diseases Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Human disease related genes Immune system diseases Allergies and autoimmune diseases Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
