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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
15
Cytoband
q25.3
Chromosome location (bp)
85380571 - 85749358
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor 1,2,3,4,5. May also activate other Rho family members 6. Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 7,8,9. Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity 10. Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 11. Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 12,13. Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 14. Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac 15. Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol 16,17. Required for normal adaptive cardiac hypertrophy in response to pressure overload 18. Plays a role in osteogenesis (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Guanine-nucleotide releasing factor
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q12802 [Direct mapping] A-kinase anchor protein 13
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SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004691[cAMP-dependent protein kinase activity] GO:0005078[MAP-kinase scaffold activity] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005938[cell cortex] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007507[heart development] GO:0015629[actin cytoskeleton] GO:0016020[membrane] GO:0030864[cortical actin cytoskeleton] GO:0031267[small GTPase binding] GO:0035023[regulation of Rho protein signal transduction] GO:0035025[positive regulation of Rho protein signal transduction] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0046872[metal ion binding] GO:0051018[protein kinase A binding] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0055007[cardiac muscle cell differentiation] GO:0060090[molecular adaptor activity] GO:0060297[regulation of sarcomere organization] GO:0060348[bone development] GO:0071875[adrenergic receptor signaling pathway] GO:0086023[adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process] GO:0110165[cellular anatomical entity]
Q12802 [Direct mapping] A-kinase anchor protein 13
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SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004691[cAMP-dependent protein kinase activity] GO:0005078[MAP-kinase scaffold activity] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005938[cell cortex] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007507[heart development] GO:0015629[actin cytoskeleton] GO:0016020[membrane] GO:0030864[cortical actin cytoskeleton] GO:0031267[small GTPase binding] GO:0035023[regulation of Rho protein signal transduction] GO:0035025[positive regulation of Rho protein signal transduction] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043406[positive regulation of MAP kinase activity] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0051018[protein kinase A binding] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0051168[nuclear export] GO:0055007[cardiac muscle cell differentiation] GO:0060090[molecular adaptor activity] GO:0060297[regulation of sarcomere organization] GO:0060348[bone development] GO:0061049[cell growth involved in cardiac muscle cell development] GO:0071875[adrenergic receptor signaling pathway] GO:0086023[adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process] GO:0110165[cellular anatomical entity]
H0YMI5 [Direct mapping] A-kinase anchor protein 13
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DeepTMHMM predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0004691[cAMP-dependent protein kinase activity] GO:0035023[regulation of Rho protein signal transduction]
Q12802 [Direct mapping] A-kinase anchor protein 13
Show all
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004691[cAMP-dependent protein kinase activity] GO:0005078[MAP-kinase scaffold activity] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005938[cell cortex] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007507[heart development] GO:0015629[actin cytoskeleton] GO:0016020[membrane] GO:0030864[cortical actin cytoskeleton] GO:0031267[small GTPase binding] GO:0035023[regulation of Rho protein signal transduction] GO:0035025[positive regulation of Rho protein signal transduction] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0046872[metal ion binding] GO:0051018[protein kinase A binding] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0055007[cardiac muscle cell differentiation] GO:0060090[molecular adaptor activity] GO:0060297[regulation of sarcomere organization] GO:0060348[bone development] GO:0071875[adrenergic receptor signaling pathway] GO:0086023[adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process] GO:0110165[cellular anatomical entity]
A0A087WY36 [Direct mapping] A-kinase anchor protein 13
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0004691[cAMP-dependent protein kinase activity] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005737[cytoplasm] GO:0035023[regulation of Rho protein signal transduction] GO:0046872[metal ion binding]
The Human Protein Atlas project is funded
